{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=buspirone", "query": { "intervention": "buspirone" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 43, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=buspirone&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-03T15:04:54.827Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01843205", "title": "Buspirone as a Candidate Medication for Methamphetamine Abuse", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Methamphetamine Dependence", "Methamphetamine Abuse" ], "interventions": [ { "name": "Methamphetamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Kentucky", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 9, "start_date": "2013-04", "completion_date": "2017-03", "has_results": true, "last_update_posted_date": "2018-02-07", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Lexington, Kentucky", "locations": [ { "city": "Lexington", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT01843205" }, { "nct_id": "NCT00021528", "title": "Sequenced Treatment Alternatives to Relieve Depression (STAR*D)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "citalopram", "type": "DRUG" }, { "name": "BuproprionSR", "type": "DRUG" }, { "name": "buspirone", "type": "DRUG" }, { "name": "Lithium", "type": "DRUG" }, { "name": "mirtazapine", "type": "DRUG" }, { "name": "nortriptyline", "type": "DRUG" }, { "name": "sertraline", "type": "DRUG" }, { "name": "tranylcypromine", "type": "DRUG" }, { "name": "VenlafaxineXR", "type": "DRUG" }, { "name": "Cognitive Therapy", "type": "BEHAVIORAL" }, { "name": "T3 (Triiodothyronine)", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 4000, "start_date": "2001-07", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2009-09-25", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Chula Vista", "state": "California" }, { "city": "Harbor City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00021528" }, { "nct_id": "NCT00875836", "title": "Buspirone Treatment for Marijuana Dependence", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Marijuana Dependence" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Medical University of South Carolina", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 175, "start_date": "2009-09", "completion_date": "2016-03", "has_results": true, "last_update_posted_date": "2016-08-10", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Charleston, South Carolina", "locations": [ { "city": "Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00875836" }, { "nct_id": "NCT02101203", "title": "Lybridos in Pre-and Postmenopausal Women With Hypoactive Sexual Desire Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypoactive Sexual Desire Disorder" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "0.5 mgTestosterone + 10 mg Buspirone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Emotional Brain NY Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "70 Years", "sex": "FEMALE", "summary": "21 Years to 70 Years · Female only" }, "enrollment_count": 80, "start_date": "2013-07", "completion_date": "2014-10", "has_results": false, "last_update_posted_date": "2015-03-24", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 10, "location_summary": "San Diego, California • Bradenton, Florida • Orlando, Florida + 7 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Bradenton", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "West Palm Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02101203" }, { "nct_id": "NCT04400266", "title": "Buspirone and Melatonin for Depression Following Traumatic Brain Injury", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression", "Brain Injuries, Traumatic" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" }, { "name": "Mealatonin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 10, "start_date": "2020-08-01", "completion_date": "2028-07-31", "has_results": false, "last_update_posted_date": "2026-05-06", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 2, "location_summary": "Boston, Massachusetts • Charlestown, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Charlestown", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04400266" }, { "nct_id": "NCT04458324", "title": "Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Spinal Cord Injuries" ], "interventions": [ { "name": "Buspirone Hydrochloride", "type": "DRUG" }, { "name": "Buspirone placebo", "type": "DRUG" }, { "name": "Noninvasive Ventilation (NIV)", "type": "DEVICE" }, { "name": "Sham Non-invasive ventilation (NIV)", "type": "DEVICE" }, { "name": "Functional Electrical Stimulation Row Training (FESRT)", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DEVICE", "OTHER" ], "sponsor": "Spaulding Rehabilitation Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 70, "start_date": "2020-12-22", "completion_date": "2027-07-31", "has_results": false, "last_update_posted_date": "2026-03-05", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Cambridge, Massachusetts", "locations": [ { "city": "Cambridge", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04458324" }, { "nct_id": "NCT05511909", "title": "Evaluating Buspirone to Treat Opioid Withdrawal", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid Use Disorder", "Opioid Withdrawal", "Opioid Craving", "Anxiety" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" }, { "name": "Lofexidine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Maryland, Baltimore", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 100, "start_date": "2022-12-15", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-08-24", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT05511909" }, { "nct_id": "NCT02458469", "title": "Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Spinal Cord Injury", "Sleep Disordered Breathing" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" }, { "name": "Trazodone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2015-05-14", "completion_date": "2019-04-12", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Detroit, Michigan", "locations": [ { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT02458469" }, { "nct_id": "NCT00360191", "title": "A Placebo-Controlled Trial of Buspirone for Treatment of Marijuana Dependence", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Marijuana Abuse" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" }, { "name": "Motivational enhancement therapy", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Medical University of South Carolina", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 81, "start_date": "2004-04", "completion_date": "2007-12", "has_results": false, "last_update_posted_date": "2012-01-12", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Charleston, South Carolina", "locations": [ { "city": "Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00360191" }, { "nct_id": "NCT04807517", "title": "Buspirone Treatment of Anxiety in Williams Syndrome", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Williams Syndrome", "Anxiety" ], "interventions": [ { "name": "Buspirone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "5 Years to 65 Years" }, "enrollment_count": 20, "start_date": "2021-08-01", "completion_date": "2023-09-11", "has_results": true, "last_update_posted_date": "2024-12-03", "last_synced_at": "2026-09-03T15:04:54.827Z", "location_count": 1, "location_summary": "Lexington, Massachusetts", "locations": [ { "city": "Lexington", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04807517" } ] }