{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=canakinumab-matching+placebo", "query": { "intervention": "canakinumab-matching placebo" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 19, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=canakinumab-matching+placebo&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-29T16:53:11.079Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00889863", "title": "Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Systemic Juvenile Idiopathic Arthritis With Active Flare" ], "interventions": [ { "name": "canakinumab", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "19 Years", "sex": "ALL", "summary": "2 Years to 19 Years" }, "enrollment_count": 177, "start_date": "2009-07", "completion_date": "2011-09", "has_results": true, "last_update_posted_date": "2012-10-16", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 12, "location_summary": "Little Rock, Arkansas • Washington D.C., District of Columbia • Chicago, Illinois + 6 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Louisville", "state": "Kentucky" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00889863" }, { "nct_id": "NCT01356602", "title": "Safety and Efficacy of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Gouty Arthritis" ], "interventions": [ { "name": "Canakinumab pre-filled syringe", "type": "DRUG" }, { "name": "Canakinumab lyophilized powder", "type": "DRUG" }, { "name": "Triamcinolone Acetonide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 397, "start_date": "2011-05", "completion_date": "2012-09", "has_results": true, "last_update_posted_date": "2014-01-29", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 69, "location_summary": "Anniston, Alabama • Gulf Shores, Alabama • Mobile, Alabama + 62 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Gulf Shores", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01356602" }, { "nct_id": "NCT02059291", "title": "Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Periodic Fevers" ], "interventions": [ { "name": "Canakinumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Month", "maximum_age": null, "sex": "ALL", "summary": "1 Month and older" }, "enrollment_count": 203, "start_date": "2014-06-27", "completion_date": "2017-07-04", "has_results": true, "last_update_posted_date": "2018-05-17", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 3, "location_summary": "Los Angeles, California • Ann Arbor, Michigan • Cleveland, Ohio", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Ann Arbor", "state": "Michigan" }, { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT02059291" }, { "nct_id": "NCT00798369", "title": "Targeted Dose Finding of Canakinumab (ACZ885) for Management of Acute Flare in Refractory or Contraindicated Gout Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Gout" ], "interventions": [ { "name": "Canakinumab", "type": "DRUG" }, { "name": "Triamcinolone acetonide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 200, "start_date": "2008-11", "completion_date": "2009-08", "has_results": true, "last_update_posted_date": "2012-04-10", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 27, "location_summary": "Anniston, Alabama • Birmingham, Alabama • Buena Park, California + 23 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Buena Park", "state": "California" }, { "city": "Oakland", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00798369" }, { "nct_id": "NCT02007252", "title": "ACZ885 for the Treatment of Abdominal Aortic Aneurysm", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Abdominal Aortic Aneurysm (AAA)" ], "interventions": [ { "name": "ACZ885", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "45 Years", "maximum_age": null, "sex": "ALL", "summary": "45 Years and older" }, "enrollment_count": 65, "start_date": "2013-12", "completion_date": "2015-10", "has_results": true, "last_update_posted_date": "2021-01-05", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 1, "location_summary": "Charlottesville, Virginia", "locations": [ { "city": "Charlottesville", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02007252" }, { "nct_id": "NCT01731990", "title": "Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Peripheral Artery Disease" ], "interventions": [ { "name": "Canakinumab (ACZ885)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 38, "start_date": "2012-10-30", "completion_date": "2016-08-04", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 8, "location_summary": "Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 4 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Lutherville", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01731990" }, { "nct_id": "NCT01160822", "title": "To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Osteoarthritis" ], "interventions": [ { "name": "Canakinumab", "type": "BIOLOGICAL" }, { "name": "Placebo to canakinumab", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Placebo to Naproxen", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "40 Years to 80 Years" }, "enrollment_count": 169, "start_date": "2010-04", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2012-10-30", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 8, "location_summary": "Anniston, Alabama • Mesa, Arizona • San Diego, California + 5 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Westlake Village", "state": "California" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01160822" }, { "nct_id": "NCT00663169", "title": "Efficacy and Safety of a Single Dose of Canakinumab (ACZ885) in Hospitalized Patients With Acute Gout", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Arthritis, Gouty" ], "interventions": [ { "name": "canakinumab", "type": "BIOLOGICAL" }, { "name": "dexamethasone", "type": "DRUG" }, { "name": "placebo matching canakinumab", "type": "OTHER" }, { "name": "placebo matching dexamethasone", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "DRUG", "OTHER" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 6, "start_date": "2008-04", "completion_date": "2009-10", "has_results": true, "last_update_posted_date": "2013-01-07", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 2, "location_summary": "Birmingham, Alabama • New Brunswick, New Jersey", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "New Brunswick", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00663169" }, { "nct_id": "NCT00581945", "title": "Safety and Efficacy of Multiple Doses of Canakinumab (ACZ885) in Chronic Obstructive Pulmonary Disease (COPD) Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "interventions": [ { "name": "Canakinumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "40 Years to 80 Years" }, "enrollment_count": 147, "start_date": "2007-01", "completion_date": "2010-05", "has_results": true, "last_update_posted_date": "2011-06-30", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 11, "location_summary": "Anaheim, California • Los Angeles, California • Panama City, Florida + 8 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Panama City", "state": "Florida" }, { "city": "Marietta", "state": "Georgia" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00581945" }, { "nct_id": "NCT03631199", "title": "Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC Subjects", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Non-small Cell Lung Cancer" ], "interventions": [ { "name": "canakinumab", "type": "DRUG" }, { "name": "canakinumab-matching placebo", "type": "DRUG" }, { "name": "pembrolizumab", "type": "DRUG" }, { "name": "carboplatin", "type": "DRUG" }, { "name": "cisplatin", "type": "DRUG" }, { "name": "paclitaxel", "type": "DRUG" }, { "name": "nab-paclitaxel", "type": "DRUG" }, { "name": "pemetrexed", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 673, "start_date": "2018-12-21", "completion_date": "2026-01-26", "has_results": true, "last_update_posted_date": "2026-06-17", "last_synced_at": "2026-09-29T16:53:11.079Z", "location_count": 4, "location_summary": "Long Beach, California • Los Angeles, California • Orlando, Florida + 1 more", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Orlando", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03631199" } ] }