{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=clarithromycin%2C+rifabutin", "query": { "intervention": "clarithromycin, rifabutin" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 12, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=clarithromycin%2C+rifabutin&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T21:05:46.066Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04553406", "title": "Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mycobacterium Avium Complex", "Non-tuberculous Mycobacterium Pulmonary Disease" ], "interventions": [ { "name": "SPR720", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Open-label Standard of Care", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Spero Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2, "start_date": "2020-12-03", "completion_date": "2021-01-28", "has_results": true, "last_update_posted_date": "2022-02-28", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 9, "location_summary": "Altamonte Springs, Florida • Atlantis, Florida • Clearwater, Florida + 6 more", "locations": [ { "city": "Altamonte Springs", "state": "Florida" }, { "city": "Atlantis", "state": "Florida" }, { "city": "Clearwater", "state": "Florida" }, { "city": "Kissimmee", "state": "Florida" }, { "city": "West Palm Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04553406" }, { "nct_id": "NCT01951326", "title": "Efficacy and Safety of Anti-MAP Therapy in Adult Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn's Disease" ], "interventions": [ { "name": "RHB-104", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "RedHill Biopharma Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 331, "start_date": "2013-09", "completion_date": "2019-08", "has_results": true, "last_update_posted_date": "2020-12-08", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 43, "location_summary": "Tucson, Arizona • Anaheim, California • La Mirada, California + 37 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "La Mirada", "state": "California" }, { "city": "San Carlos", "state": "California" }, { "city": "Ventura", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01951326" }, { "nct_id": "NCT00001047", "title": "Study of Four Different Treatment Approaches for Patients Who Have Mycobacterium Avium Complex Disease (MAC) Plus AIDS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mycobacterium Avium-intracellulare Infection", "HIV Infections" ], "interventions": [ { "name": "Ethambutol hydrochloride", "type": "DRUG" }, { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Clofazimine", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": null, "sex": "ALL", "summary": "13 Years and older" }, "enrollment_count": 400, "start_date": null, "completion_date": "1996-08", "has_results": false, "last_update_posted_date": "2021-11-04", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 16, "location_summary": "San Francisco, California • Denver, Colorado • Washington D.C., District of Columbia + 12 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001047" }, { "nct_id": "NCT00001023", "title": "The Safety and Effectiveness of Rifabutin, Combined With Clarithromycin or Azithromycin, in HIV-Infected Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Mycobacterium Avium-intracellulare Infection", "HIV Infections" ], "interventions": [ { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Azithromycin", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 91, "start_date": null, "completion_date": "1998-07", "has_results": false, "last_update_posted_date": "2012-10-31", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 11, "location_summary": "Tucson, Arizona • Palo Alto, California • San Francisco, California + 8 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Palo Alto", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001023" }, { "nct_id": "NCT00000826", "title": "Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Bacterial Infections", "Mycoses", "HIV Infections" ], "interventions": [ { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" }, { "name": "Sulfamethoxazole-Trimethoprim", "type": "DRUG" }, { "name": "Dapsone", "type": "DRUG" }, { "name": "Fluconazole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 48, "start_date": null, "completion_date": "1999-05", "has_results": false, "last_update_posted_date": "2021-10-29", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 2, "location_summary": "San Francisco, California • Seattle, Washington", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00000826" }, { "nct_id": "NCT00002101", "title": "A Three-Arm Comparative Trial for the Treatment of MAC Bacteremia in AIDS: A Clarithromycin/Ethambutol Regimen Containing Rifabutin (450 Mg) or Rifabutin (300 Mg) or Placebo", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mycobacterium Avium-Intracellulare Infection", "HIV Infections" ], "interventions": [ { "name": "Ethambutol hydrochloride", "type": "DRUG" }, { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharmacia", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": null, "sex": "ALL", "summary": "13 Years and older" }, "enrollment_count": 450, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2005-06-24", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 44, "location_summary": "Phoenix, Arizona • Harbor City, California • Irvine, California + 34 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Harbor City", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00002101" }, { "nct_id": "NCT00001058", "title": "A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mycobacterium Avium-intracellulare Infection", "HIV Infections" ], "interventions": [ { "name": "Indinavir sulfate", "type": "DRUG" }, { "name": "Ritonavir", "type": "DRUG" }, { "name": "Ethambutol hydrochloride", "type": "DRUG" }, { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": null, "sex": "ALL", "summary": "13 Years and older" }, "enrollment_count": 246, "start_date": null, "completion_date": "1999-01", "has_results": false, "last_update_posted_date": "2021-11-01", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 33, "location_summary": "Birmingham, Alabama • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001058" }, { "nct_id": "NCT04616924", "title": "RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pulmonary Mycobacterium Avium Complex Infection", "Bronchiectasis", "Lung Diseases" ], "interventions": [ { "name": "RHB-204", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "RedHill Biopharma Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 12, "start_date": "2020-12-01", "completion_date": "2023-08-28", "has_results": false, "last_update_posted_date": "2025-03-18", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 25, "location_summary": "Glendale, California • Palm Springs, California • Farmington, Connecticut + 21 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Palm Springs", "state": "California" }, { "city": "Farmington", "state": "Connecticut" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Clearwater", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04616924" }, { "nct_id": "NCT03009396", "title": "Open Label Efficacy and Safety of Anti-MAP (Mycobacterium Avium Ssp. Paratuberculosis) Therapy in Adult Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn Disease" ], "interventions": [ { "name": "RHB-104 (fixed-dose combination: 95 mg clarithromycin, 45 mg rifabutin, and 10 mg clofazimine)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "RedHill Biopharma Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "76 Years", "sex": "ALL", "summary": "18 Years to 76 Years" }, "enrollment_count": 54, "start_date": "2017-03-18", "completion_date": "2019-08-19", "has_results": true, "last_update_posted_date": "2021-02-24", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 6, "location_summary": "San Carlos, California • Marietta, Georgia • Topeka, Kansas + 3 more", "locations": [ { "city": "San Carlos", "state": "California" }, { "city": "Marietta", "state": "Georgia" }, { "city": "Topeka", "state": "Kansas" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "Brockton", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03009396" }, { "nct_id": "NCT00001030", "title": "The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mycobacterium Avium-intracellulare Infection", "HIV Infections" ], "interventions": [ { "name": "Clarithromycin", "type": "DRUG" }, { "name": "Rifabutin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 1100, "start_date": null, "completion_date": "1996-06", "has_results": false, "last_update_posted_date": "2021-11-01", "last_synced_at": "2026-09-30T21:05:46.066Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Los Angeles, California • Oakland, California + 24 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Oakland", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001030" } ] }