{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=e-cig+with+nicotine&page=5",
    "query": {
      "intervention": "e-cig with nicotine",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 173,
    "total_pages": 18,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=e-cig+with+nicotine&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=e-cig+with+nicotine&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-10T17:11:34.876Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05023096",
      "title": "Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Nicotine Delivery System Flavors"
      ],
      "interventions": [
        {
          "name": "Tobacco product administration and assessment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 71,
      "start_date": "2022-04-14",
      "completion_date": "2024-10-15",
      "has_results": true,
      "last_update_posted_date": "2026-04-22",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05023096"
    },
    {
      "nct_id": "NCT02724241",
      "title": "E-Cigarettes and SNA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "one time exposure to e-cig with nicotine",
          "type": "OTHER"
        },
        {
          "name": "One time exposure to e-cigarette without nicotine",
          "type": "OTHER"
        },
        {
          "name": "one time exposure to empty e-cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 100,
      "start_date": "2015-04",
      "completion_date": "2021-12",
      "has_results": false,
      "last_update_posted_date": "2021-12-20",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02724241"
    },
    {
      "nct_id": "NCT02955329",
      "title": "Vaping THC From Electronic Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Marijuana Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Cannabis",
          "type": "DRUG"
        },
        {
          "name": "PAX Loose Leaf Vaporizer",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 8,
      "start_date": "2019-03-20",
      "completion_date": "2019-11-30",
      "has_results": true,
      "last_update_posted_date": "2023-06-29",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02955329"
    },
    {
      "nct_id": "NCT04003805",
      "title": "Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Smoking, Cigarette"
      ],
      "interventions": [
        {
          "name": "Standardized Research E-cigarette (SREC)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Masonic Cancer Center, University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 47,
      "start_date": "2022-05-11",
      "completion_date": "2026-08-20",
      "has_results": true,
      "last_update_posted_date": "2026-06-24",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04003805"
    },
    {
      "nct_id": "NCT02612701",
      "title": "E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Myocardial Perfusion"
      ],
      "interventions": [
        {
          "name": "Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (nicotine free e-liquid)",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (low nicotine e-liquid)",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (high nicotine e-liquid)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "49 Years",
        "sex": "ALL",
        "summary": "18 Years to 49 Years"
      },
      "enrollment_count": 20,
      "start_date": "2015-10",
      "completion_date": "2020-10",
      "has_results": false,
      "last_update_posted_date": "2021-02-04",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02612701"
    },
    {
      "nct_id": "NCT04332926",
      "title": "Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Tobacco product administration and assessment, own brand cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine",
          "type": "OTHER"
        },
        {
          "name": "Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine",
          "type": "OTHER"
        },
        {
          "name": "Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine",
          "type": "OTHER"
        },
        {
          "name": "Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 44,
      "start_date": "2021-01-05",
      "completion_date": "2023-09-08",
      "has_results": true,
      "last_update_posted_date": "2025-02-13",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04332926"
    },
    {
      "nct_id": "NCT03635333",
      "title": "Effects of E-Cigarette Flavors on Adults TCORS 2.0",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Flavor",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 130,
      "start_date": "2019-05-14",
      "completion_date": "2023-07-12",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635333"
    },
    {
      "nct_id": "NCT05205382",
      "title": "Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "5% nicotine (Partial Nicotine Reduction)",
          "type": "OTHER"
        },
        {
          "name": "3% or 2.4% nicotine (Partial Nicotine Reduction)",
          "type": "OTHER"
        },
        {
          "name": "5% nicotine (Total Nicotine Reduction)",
          "type": "OTHER"
        },
        {
          "name": "0% nicotine (Total Nicotine Reduction)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Florida International University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "21 Years to 35 Years"
      },
      "enrollment_count": 116,
      "start_date": "2022-04-01",
      "completion_date": "2025-04-15",
      "has_results": true,
      "last_update_posted_date": "2026-08-13",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05205382"
    },
    {
      "nct_id": "NCT04047836",
      "title": "Vaping High vs. Low Nicotine E-Liquid",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Risk Factor",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Low Nicotine E-Liquid",
          "type": "OTHER"
        },
        {
          "name": "Medium or High Nicotine E-Liquid",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 0,
      "start_date": "2023-06-01",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-08-22",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 2,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047836"
    },
    {
      "nct_id": "NCT03185546",
      "title": "Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "NNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "VLNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "Moderate nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Low nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Tobacco Flavors",
          "type": "OTHER"
        },
        {
          "name": "Tobacco and non-tobacco e-liquid flavors",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 156,
      "start_date": "2018-08-06",
      "completion_date": "2020-03-13",
      "has_results": true,
      "last_update_posted_date": "2021-05-14",
      "last_synced_at": "2026-10-10T17:11:34.876Z",
      "location_count": 2,
      "location_summary": "Winston-Salem, North Carolina • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03185546"
    }
  ]
}