{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=5",
    "query": {
      "intervention": "flavor and nicotine",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 124,
    "total_pages": 13,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-13T04:16:15.906Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04038515",
      "title": "Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine",
        "E-liquid Flavors"
      ],
      "interventions": [
        {
          "name": "Nicotine 0 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 6 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 12 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 24 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "'Menthol' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Menthol/Mint' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Green Apple' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Watermelon' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Unflavored'",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 54,
      "start_date": "2022-10-27",
      "completion_date": "2024-06-03",
      "has_results": false,
      "last_update_posted_date": "2024-08-05",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04038515"
    },
    {
      "nct_id": "NCT03185546",
      "title": "Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "NNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "VLNC Spectrum Cigarette",
          "type": "OTHER"
        },
        {
          "name": "Moderate nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Low nicotine level e-liquid",
          "type": "OTHER"
        },
        {
          "name": "Tobacco Flavors",
          "type": "OTHER"
        },
        {
          "name": "Tobacco and non-tobacco e-liquid flavors",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 156,
      "start_date": "2018-08-06",
      "completion_date": "2020-03-13",
      "has_results": true,
      "last_update_posted_date": "2021-05-14",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 2,
      "location_summary": "Winston-Salem, North Carolina • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03185546"
    },
    {
      "nct_id": "NCT04092387",
      "title": "Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Varying the nicotine content of cigarettes",
          "type": "OTHER"
        },
        {
          "name": "E-Cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "44 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 44 Years · Female only"
      },
      "enrollment_count": 326,
      "start_date": "2020-10-18",
      "completion_date": "2023-11-27",
      "has_results": true,
      "last_update_posted_date": "2025-03-18",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Burlington, Vermont",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04092387"
    },
    {
      "nct_id": "NCT07786896",
      "title": "Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "E Cigarette Use",
        "Cessation, Tobacco",
        "Cessation, Nicotine"
      ],
      "interventions": [
        {
          "name": "Nicotine Replacement Therapies",
          "type": "DRUG"
        },
        {
          "name": "Brief Behavioral Counseling",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "West Virginia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-09-01",
      "completion_date": "2028-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 2,
      "location_summary": "Greenville, North Carolina • Morgantown, West Virginia",
      "locations": [
        {
          "city": "Greenville",
          "state": "North Carolina"
        },
        {
          "city": "Morgantown",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07786896"
    },
    {
      "nct_id": "NCT05278065",
      "title": "E-cigarettes for Harm Reduction in Adults With Asthma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Asthma",
        "Electronic Cigarette Use",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 17,
      "start_date": "2022-05-01",
      "completion_date": "2024-09-12",
      "has_results": true,
      "last_update_posted_date": "2025-11-18",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05278065"
    },
    {
      "nct_id": "NCT06506162",
      "title": "Abuse Liability and Appeal of Oral Nicotine Products",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Flavor",
          "type": "OTHER"
        },
        {
          "name": "Nicotine concentration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "21 Years to 25 Years"
      },
      "enrollment_count": 320,
      "start_date": "2024-02-09",
      "completion_date": "2028-02-14",
      "has_results": false,
      "last_update_posted_date": "2026-07-09",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06506162"
    },
    {
      "nct_id": "NCT05257109",
      "title": "Water Content in E-Liquids",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine E-Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Water Concentration 1",
          "type": "OTHER"
        },
        {
          "name": "Water Concentration 2",
          "type": "OTHER"
        },
        {
          "name": "Water Concentration 3",
          "type": "OTHER"
        },
        {
          "name": "Water Concentration 4",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 31,
      "start_date": "2022-08-01",
      "completion_date": "2023-03-10",
      "has_results": true,
      "last_update_posted_date": "2024-10-22",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05257109"
    },
    {
      "nct_id": "NCT07095140",
      "title": "Studying the Effects of Nicotine Concentration and Flavor on Alcohol Use in Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol-Related Carcinoma"
      ],
      "interventions": [
        {
          "name": "Ecological Momentary Assessment",
          "type": "OTHER"
        },
        {
          "name": "Monitoring",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Oral Pouch",
          "type": "DRUG"
        },
        {
          "name": "Survey Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "21 Years to 30 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-09-03",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-11-26",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07095140"
    },
    {
      "nct_id": "NCT07771725",
      "title": "Impact of Sweeteners on the Addictive Threshold of Nicotine",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Smoking ( Cigarette)"
      ],
      "interventions": [
        {
          "name": "Nicotine 0.05 mg/pulse and 0.1 mg/pulse",
          "type": "DRUG"
        },
        {
          "name": "Saline Placebo (0.5mL injection)",
          "type": "DRUG"
        },
        {
          "name": "sucralose",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sugar syrup (Placebo)",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "21 Years to 59 Years"
      },
      "enrollment_count": 36,
      "start_date": "2026-09-01",
      "completion_date": "2029-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-31",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 1,
      "location_summary": "West Haven, Connecticut",
      "locations": [
        {
          "city": "West Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07771725"
    },
    {
      "nct_id": "NCT04123041",
      "title": "Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use",
        "Tobacco Smoking"
      ],
      "interventions": [
        {
          "name": "JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Juul Labs, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 137,
      "start_date": "2019-09-23",
      "completion_date": "2019-12-18",
      "has_results": false,
      "last_update_posted_date": "2020-02-13",
      "last_synced_at": "2026-10-13T04:16:15.906Z",
      "location_count": 2,
      "location_summary": "Kansas City, Kansas • Lexington, Kentucky",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04123041"
    }
  ]
}