{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=6",
    "query": {
      "intervention": "flavor and nicotine",
      "page": 6
    },
    "page_size": 10
  },
  "pagination": {
    "page": 6,
    "page_size": 10,
    "total_count": 124,
    "total_pages": 13,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=7&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=flavor+and+nicotine&page=5&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-14T13:56:21.352Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06919276",
      "title": "Nicotine and Cannabis Vape Labeling Experiment - Spring 2025",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vaping",
        "Adolescent",
        "Electronic Cigarette Use",
        "Nicotine",
        "Cannabis"
      ],
      "interventions": [
        {
          "name": "Vaping Device Labeling",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "19 Years",
        "sex": "ALL",
        "summary": "11 Years to 19 Years"
      },
      "enrollment_count": 3048,
      "start_date": "2025-03-03",
      "completion_date": "2025-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06919276"
    },
    {
      "nct_id": "NCT05439421",
      "title": "Consumer Perceptions of Waterpipe Tobacco Packaging and Digital Marketing Claims",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Waterpipe Tobacco Smoking"
      ],
      "interventions": [
        {
          "name": "Package/Advertisement With Claim",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Package/Advertisement Without Claim",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "18 Years to 29 Years"
      },
      "enrollment_count": 1507,
      "start_date": "2022-10-25",
      "completion_date": "2022-11-23",
      "has_results": true,
      "last_update_posted_date": "2024-03-19",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05439421"
    },
    {
      "nct_id": "NCT03168191",
      "title": "Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Experimental Flavor",
          "type": "OTHER"
        },
        {
          "name": "Menthol Flavor",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "18 Years to 20 Years"
      },
      "enrollment_count": 56,
      "start_date": "2017-05-02",
      "completion_date": "2019-02-25",
      "has_results": false,
      "last_update_posted_date": "2020-05-04",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03168191"
    },
    {
      "nct_id": "NCT05499377",
      "title": "The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Tobacco product administration and assessment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 33,
      "start_date": "2022-11-28",
      "completion_date": "2023-09-22",
      "has_results": true,
      "last_update_posted_date": "2025-01-31",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05499377"
    },
    {
      "nct_id": "NCT05932693",
      "title": "Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-Cig Use"
      ],
      "interventions": [
        {
          "name": "E-liquid coolant (WS-3, 0.05%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-3, 0.1%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-3, 0.5%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-3, 1.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-3, 2.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (menthol, 0.05%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (menthol, 0.1%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (menthol, 0.5%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (menthol, 1.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (menthol, 2.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 0.05%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 0.1%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 0.5%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 1.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 2.0%)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (WS-23, 4.0%)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 31,
      "start_date": "2024-09-03",
      "completion_date": "2025-01-09",
      "has_results": true,
      "last_update_posted_date": "2026-02-18",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05932693"
    },
    {
      "nct_id": "NCT06554873",
      "title": "Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Smoking Cessation",
        "Harm Reduction"
      ],
      "interventions": [
        {
          "name": "Nicoderm",
          "type": "DRUG"
        },
        {
          "name": "Nicorette 4Mg Chewing Gum",
          "type": "DRUG"
        },
        {
          "name": "Nicorette Lozenge Product",
          "type": "DRUG"
        },
        {
          "name": "NJOY e-cigarette",
          "type": "OTHER"
        },
        {
          "name": "on!",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 150,
      "start_date": "2024-08-29",
      "completion_date": "2025-12-09",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 2,
      "location_summary": "Charlotte, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06554873"
    },
    {
      "nct_id": "NCT04521647",
      "title": "Effects of Menthol in E-cigarettes on Smoking Behaviors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 14,
      "start_date": "2022-05-10",
      "completion_date": "2023-07-25",
      "has_results": true,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04521647"
    },
    {
      "nct_id": "NCT05457634",
      "title": "Nicotine Uptake and Abuse Liability Assessments of Blu Disposable Electronic Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "Combustible Cigarette",
          "type": "OTHER"
        },
        {
          "name": "blu Disposable A",
          "type": "OTHER"
        },
        {
          "name": "blu Disposable B",
          "type": "OTHER"
        },
        {
          "name": "blu Disposable C",
          "type": "OTHER"
        },
        {
          "name": "blu Disposable D",
          "type": "OTHER"
        },
        {
          "name": "blu Disposable E",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Fontem US LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 20,
      "start_date": "2021-07-13",
      "completion_date": "2024-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-17",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "Burbank, California",
      "locations": [
        {
          "city": "Burbank",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05457634"
    },
    {
      "nct_id": "NCT02499757",
      "title": "Does Sweet Taste Potentiate Nicotine Cue Reactivity?",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "flavor and sweetener",
          "type": "DEVICE"
        },
        {
          "name": "flavor and nicotine",
          "type": "DEVICE"
        },
        {
          "name": "flavor, nicotine and sweetener",
          "type": "DEVICE"
        },
        {
          "name": "flavor",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 15,
      "start_date": "2015-05",
      "completion_date": "2015-11",
      "has_results": false,
      "last_update_posted_date": "2020-03-09",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02499757"
    },
    {
      "nct_id": "NCT01509586",
      "title": "A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 1236,
      "start_date": "2011-11",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2023-07-12",
      "last_synced_at": "2026-10-14T13:56:21.352Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01509586"
    }
  ]
}