{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=fluoride+toothpaste&page=2",
    "query": {
      "intervention": "fluoride toothpaste",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=fluoride+toothpaste&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T08:14:53.547Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01549587",
      "title": "Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis",
        "Pregnancy"
      ],
      "interventions": [
        {
          "name": "0.243% sodium fluoride",
          "type": "DRUG"
        },
        {
          "name": "toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "dental floss",
          "type": "DEVICE"
        },
        {
          "name": "0.454% stannous fluoride",
          "type": "DRUG"
        },
        {
          "name": "0.07% Cetylpyridinium chloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 746,
      "start_date": "2012-02",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2023-04-21",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 2,
      "location_summary": "Birmingham, Alabama • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01549587"
    },
    {
      "nct_id": "NCT05459558",
      "title": "Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "Experimental Dentifrice 1",
          "type": "DRUG"
        },
        {
          "name": "Experimental Dentifrice 2",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 280,
      "start_date": "2022-09-15",
      "completion_date": "2022-12-04",
      "has_results": true,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05459558"
    },
    {
      "nct_id": "NCT03381339",
      "title": "Powertoothbrushing for Treating Gingivitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Oscillating rotating power toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Marquette University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 55,
      "start_date": "2017-12-05",
      "completion_date": "2019-06-25",
      "has_results": true,
      "last_update_posted_date": "2021-04-05",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03381339"
    },
    {
      "nct_id": "NCT00759031",
      "title": "Investigation of Dental Plaque and Gingival Index",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Sodium Monofluorophosphate",
          "type": "DRUG"
        },
        {
          "name": "Triclosan/Fluoride/Copolymer",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 19,
      "start_date": "2008-02",
      "completion_date": "2008-03",
      "has_results": true,
      "last_update_posted_date": "2012-04-13",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00759031"
    },
    {
      "nct_id": "NCT02589938",
      "title": "Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Radiation-Induced Xerostomia",
        "Head and Neck Cancer",
        "Radiation Toxicity",
        "Oral Complications of Chemotherapy and Head/Neck Radiation"
      ],
      "interventions": [
        {
          "name": "Standard Oral Hygiene",
          "type": "OTHER"
        },
        {
          "name": "Standard Oral Hygiene + True Acupuncture",
          "type": "OTHER"
        },
        {
          "name": "Standard Oral Hygiene + Sham Acupuncture",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 258,
      "start_date": "2012-11-11",
      "completion_date": "2022-07-29",
      "has_results": true,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 36,
      "location_summary": "Burbank, California • San Francisco, California • San Jose, California + 26 more",
      "locations": [
        {
          "city": "Burbank",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "San Rafael",
          "state": "California"
        },
        {
          "city": "San Rafael",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02589938"
    },
    {
      "nct_id": "NCT06122376",
      "title": "Plaque and Gingivitis Evaluation of a U-Shaped Toothbrush in a 30-Day Model",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Plaque Induced Gingivitis"
      ],
      "interventions": [
        {
          "name": "U-shaped Power Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "Soft Manual Toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Lander Enterprises, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "5 Years to 65 Years"
      },
      "enrollment_count": 75,
      "start_date": "2023-05-31",
      "completion_date": "2023-07-14",
      "has_results": false,
      "last_update_posted_date": "2023-11-08",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06122376"
    },
    {
      "nct_id": "NCT07755800",
      "title": "Impact of an Arginine-containing Toothpaste on the Subgingival Microbiota in Patients in Supportive Periodontal Care",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gum Disease"
      ],
      "interventions": [
        {
          "name": "Arginine Toothpaste",
          "type": "DEVICE"
        },
        {
          "name": "Fluoride Toothpaste",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sukirth M Ganesan, BDS, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 108,
      "start_date": "2026-08-05",
      "completion_date": "2028-07",
      "has_results": false,
      "last_update_posted_date": "2026-09-10",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07755800"
    },
    {
      "nct_id": "NCT06140784",
      "title": "A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "0.76% Sodium Monofluorophosphate Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "0.454% Stannous Fluoride Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 116,
      "start_date": "2023-09-02",
      "completion_date": "2023-12-10",
      "has_results": false,
      "last_update_posted_date": "2024-03-01",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Whittier, California",
      "locations": [
        {
          "city": "Whittier",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06140784"
    },
    {
      "nct_id": "NCT01059058",
      "title": "Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Demineralization"
      ],
      "interventions": [
        {
          "name": "MI Paste Plus",
          "type": "PROCEDURE"
        },
        {
          "name": "PreviDent Fluoride Varnish",
          "type": "PROCEDURE"
        },
        {
          "name": "Normal Home Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "12 Years to 20 Years"
      },
      "enrollment_count": 240,
      "start_date": "2010-03",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2015-08-17",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01059058"
    },
    {
      "nct_id": "NCT04155658",
      "title": "Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Enamel Caries"
      ],
      "interventions": [
        {
          "name": "Experimental Toothpaste containing 1450ppm SMFP",
          "type": "OTHER"
        },
        {
          "name": "Toothpaste containing 1450ppm SMFP",
          "type": "OTHER"
        },
        {
          "name": "Toothpaste with no fluoride",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Unilever R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 55,
      "start_date": "2019-11-25",
      "completion_date": "2020-04-30",
      "has_results": false,
      "last_update_posted_date": "2020-05-18",
      "last_synced_at": "2026-09-11T08:14:53.547Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04155658"
    }
  ]
}