{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=guanfacine&page=2", "query": { "intervention": "guanfacine", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=guanfacine&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-29T17:41:33.329Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05305404", "title": "Dexamethasone to Target Stress and Immune System Mechanisms Underlying Alcohol Craving", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Alcohol Use Disorder" ], "interventions": [ { "name": "Dexamethasone Oral", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Stony Brook University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 70, "start_date": "2022-03-11", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2022-07-28", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Stony Brook, New York", "locations": [ { "city": "Stony Brook", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05305404" }, { "nct_id": "NCT00997984", "title": "Tolerability and Efficacy of AM and PM Once Daily Dosing With Extended-release Guanfacine Hydrochloride in Children 6-12 With Attention-Deficit/Hyperactivity Disorder (ADHD) (The ADHD Tempo Study)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Attention-Deficit/Hyperactivity Disorder" ], "interventions": [ { "name": "extended-release guanfacine hydrochloride (SPD503)", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "extended-release guanfacine hydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "6 Years to 12 Years" }, "enrollment_count": 340, "start_date": "2009-11-17", "completion_date": "2010-10-09", "has_results": true, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 42, "location_summary": "Little Rock, Arkansas • El Centro, California • Rolling Hills Estates, California + 38 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "El Centro", "state": "California" }, { "city": "Rolling Hills Estates", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Wildomar", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00997984" }, { "nct_id": "NCT03865940", "title": "Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Trigeminal Neuralgia" ], "interventions": [ { "name": "Lidocaine", "type": "DRUG" }, { "name": "Guanfacine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 37, "start_date": "2019-11-04", "completion_date": "2024-01-31", "has_results": true, "last_update_posted_date": "2025-03-30", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03865940" }, { "nct_id": "NCT00429273", "title": "Single Versus Combination Medication Treatment for Children With Attention Deficit Hyperactivity Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Attention Deficit Disorder With Hyperactivity" ], "interventions": [ { "name": "Guanfacine", "type": "DRUG" }, { "name": "Methylphenidate (MPH)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "7 Years", "maximum_age": "14 Years", "sex": "ALL", "summary": "7 Years to 14 Years" }, "enrollment_count": 212, "start_date": "2007-01", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2021-07-30", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00429273" }, { "nct_id": "NCT00469664", "title": "Guanfacine Adjunctive Treatment to Atypical Antipsychotics for Cognitive Dysfunction in Schizophrenia", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia", "Schizoaffective Disorder", "Cognitive Impairment" ], "interventions": [ { "name": "Guanfacine/Tenex", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Research Foundation for Mental Hygiene, Inc.", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 50, "start_date": "2000-02", "completion_date": "2008-12", "has_results": false, "last_update_posted_date": "2008-05-21", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 3, "location_summary": "New York, New York • The Bronx, New York • W. Brentwood, New York", "locations": [ { "city": "New York", "state": "New York" }, { "city": "The Bronx", "state": "New York" }, { "city": "W. Brentwood", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00469664" }, { "nct_id": "NCT06042257", "title": "Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hyperactivity in Children With Down Syndrome", "Impulsivity in Children With Down Syndrome" ], "interventions": [ { "name": "Guanfacine Hydrochloride Immediate Release", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Rachel G. Greenberg, MD, MB, MHS", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "6 Years", "maximum_age": "12 Years", "sex": "ALL", "summary": "6 Years to 12 Years" }, "enrollment_count": 3, "start_date": "2024-12-09", "completion_date": "2025-08-12", "has_results": false, "last_update_posted_date": "2026-04-17", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 14, "location_summary": "Phoenix, Arizona • Atlanta, Georgia • Chicago, Illinois + 11 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Iowa City", "state": "Iowa" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT06042257" }, { "nct_id": "NCT00919867", "title": "A Drug Interaction Study of SPD503 and Vyvanse Administered Alone and In Combination in Normal Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "SPD503", "type": "DRUG" }, { "name": "VYVANSE", "type": "DRUG" }, { "name": "SPD503 and VYVANSE", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 42, "start_date": "2009-06-24", "completion_date": "2009-07-30", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Hackensack, New Jersey", "locations": [ { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00919867" }, { "nct_id": "NCT00223717", "title": "Treatment of Supine Hypertension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Clonidine", "type": "DRUG" }, { "name": "Nitroglycerin transdermal", "type": "DRUG" }, { "name": "Dipyridamole/ Aspirin (Aggrenox)", "type": "DRUG" }, { "name": "Desmopressin (DDAVP)", "type": "DRUG" }, { "name": "Sildenafil", "type": "DRUG" }, { "name": "Nifedipine", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Bosentan", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" }, { "name": "Eplerenone", "type": "DRUG" }, { "name": "guanfacine", "type": "DRUG" }, { "name": "L-arginine", "type": "DIETARY_SUPPLEMENT" }, { "name": "captopril", "type": "DRUG" }, { "name": "carbidopa", "type": "DRUG" }, { "name": "losartan", "type": "DRUG" }, { "name": "metoprolol tartrate", "type": "DRUG" }, { "name": "nebivolol hydrochloride", "type": "DRUG" }, { "name": "prazosin hydrochloride", "type": "DRUG" }, { "name": "tamsulosin hydrochloride", "type": "DRUG" }, { "name": "Head-up tilt.", "type": "OTHER" }, { "name": "aliskiren", "type": "DRUG" }, { "name": "Local heat stress", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 152, "start_date": "2001-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223717" }, { "nct_id": "NCT03258476", "title": "Guanfacine Extended Release and Mindfulness Skills Therapy", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Stress Disorder" ], "interventions": [ { "name": "Guanfacine Extended Release", "type": "DRUG" }, { "name": "Mindfulness Skills Therapy", "type": "BEHAVIORAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "UConn Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "20 Years", "sex": "ALL", "summary": "10 Years to 20 Years" }, "enrollment_count": 0, "start_date": "2019-03-01", "completion_date": "2019-12-03", "has_results": false, "last_update_posted_date": "2021-03-08", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "Farmington, Connecticut", "locations": [ { "city": "Farmington", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03258476" }, { "nct_id": "NCT00773357", "title": "Modeling Stress-precipitated Smoking Behavior for Medication Development", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Smoking" ], "interventions": [ { "name": "guanfacine", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 100, "start_date": "2008-10", "completion_date": "2021-07-31", "has_results": true, "last_update_posted_date": "2022-08-03", "last_synced_at": "2026-09-29T17:41:33.329Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00773357" } ] }