{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=huCART19", "query": { "intervention": "huCART19" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-06T11:59:16.950Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04684563", "title": "huCART19-IL18 in CD19+ Cancers", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Chronic Lymphocytic Leukemia", "Non-hodgkin Lymphoma", "Acute Lymphoblastic Leukemia" ], "interventions": [ { "name": "huCART19-IL18", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 72, "start_date": "2021-05-06", "completion_date": "2036-05", "has_results": false, "last_update_posted_date": "2025-11-10", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04684563" }, { "nct_id": "NCT07343934", "title": "huCART19-IL18-eDHFR Cells in Relapsed/Refractory Follicular Lymphoma", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Relapsed or Refractory Follicular Lymphoma" ], "interventions": [ { "name": "huCART19-IL18-eDHFR cells", "type": "BIOLOGICAL" }, { "name": "[18F]Fluoropropyl-Trimethoprim", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6, "start_date": "2026-05-18", "completion_date": "2042-11", "has_results": false, "last_update_posted_date": "2026-05-26", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT07343934" }, { "nct_id": "NCT04419909", "title": "Retreatment With CTL019/CTL119", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Lymphoma, B-Cell" ], "interventions": [ { "name": "CD19 redirected autologous T cells (CTL019 or CTL119 cells)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2026-05", "completion_date": "2026-07-15", "has_results": false, "last_update_posted_date": "2026-07-22", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04419909" }, { "nct_id": "NCT06056102", "title": "CAR-T Cell Therapy for Desensitization in Kidney Transplantation", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Kidney Transplant", "Kidney Failure", "End Stage Renal Failure on Dialysis" ], "interventions": [ { "name": "Cyclophosphamide", "type": "DRUG" }, { "name": "CART-BCMA", "type": "BIOLOGICAL" }, { "name": "huCART19", "type": "BIOLOGICAL" }, { "name": "Fludarabine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 20, "start_date": "2024-05-09", "completion_date": "2042-12-15", "has_results": false, "last_update_posted_date": "2026-05-22", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 3, "location_summary": "Boston, Massachusetts • New York, New York • Philadelphia, Pennsylvania", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06056102" }, { "nct_id": "NCT03620058", "title": "CART22 Alone or in Combination With huCART19 for ALL", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Chemotherapy Resistant Acute Lymphoblastic Leukemia", "Refractory Acute Lymphoblastic Leukemia" ], "interventions": [ { "name": "CART22-65s cells", "type": "BIOLOGICAL" }, { "name": "huCART19 Cells", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 23, "start_date": "2018-09-27", "completion_date": "2036-01", "has_results": false, "last_update_posted_date": "2025-10-14", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03620058" }, { "nct_id": "NCT05480449", "title": "Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "B Cell Acute Lymphoblastic Leukemia (B-ALL)", "B Lineage Lymphoblastic Lymphoma" ], "interventions": [ { "name": "Autologous Humanized CD19-Directed Chimeric Antigen Receptor T-Cells (huCART19)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Stephan Grupp MD PhD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Years", "maximum_age": "29 Years", "sex": "ALL", "summary": "0 Years to 29 Years" }, "enrollment_count": 115, "start_date": "2022-09-20", "completion_date": "2029-09-20", "has_results": false, "last_update_posted_date": "2026-05-26", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05480449" }, { "nct_id": "NCT05674175", "title": "Co-administration of CART22-65s and huCART19 for B-ALL", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "B-cell Acute Lymphoblastic Leukemia", "B Lineage Lymphoblastic Lymphoma" ], "interventions": [ { "name": "Autologous, humanized anti-CD22 CAR T cell therapy (CART22-65s)", "type": "BIOLOGICAL" }, { "name": "Autologous, humanized anti-CD19 CAR T cell therapy (huCART19)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Stephan Grupp MD PhD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "29 Years", "sex": "ALL", "summary": "Up to 29 Years" }, "enrollment_count": 93, "start_date": "2023-01-25", "completion_date": "2029-07-01", "has_results": false, "last_update_posted_date": "2026-03-27", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05674175" }, { "nct_id": "NCT03549442", "title": "Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Multiple Myeloma" ], "interventions": [ { "name": "BCMA CART + huCART19", "type": "BIOLOGICAL" }, { "name": "CART BCMA or CART BCMA + huCART19", "type": "BIOLOGICAL" }, { "name": "Single-dose infusion of CART BCMA or CART BCMA + huCART19", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2018-05-09", "completion_date": "2036-03", "has_results": false, "last_update_posted_date": "2026-07-10", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03549442" }, { "nct_id": "NCT03792633", "title": "Study of huCART19 for Very High-Risk (VHR) Subsets of Pediatric B-ALL", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Lymphoblastic Leukemia" ], "interventions": [ { "name": "huCART19", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Months", "maximum_age": "29 Years", "sex": "ALL", "summary": "3 Months to 29 Years" }, "enrollment_count": 106, "start_date": "2019-01-18", "completion_date": "2024-04-04", "has_results": true, "last_update_posted_date": "2025-06-05", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03792633" }, { "nct_id": "NCT02374333", "title": "Pilot Study of Redirected Autologous T Cells Engineered to Contain Humanized Anti-CD19 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma Previously Treated With Cell Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Acute Lymphocytic Leukemia", "Diffuse Large Cell Lymphoma" ], "interventions": [ { "name": "huCART19", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "24 Years", "sex": "ALL", "summary": "1 Year to 24 Years" }, "enrollment_count": 81, "start_date": "2014-03-25", "completion_date": "2021-09-02", "has_results": false, "last_update_posted_date": "2021-09-23", "last_synced_at": "2026-09-06T11:59:16.950Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02374333" } ] }