{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=hydroquinone+cream",
    "query": {
      "intervention": "hydroquinone cream"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 8,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T10:22:22.047Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07644871",
      "title": "A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hyperpigmentation",
        "Melasma",
        "Dark Spots"
      ],
      "interventions": [
        {
          "name": "Facial Cleanser",
          "type": "OTHER"
        },
        {
          "name": "Facial Moisturizer",
          "type": "OTHER"
        },
        {
          "name": "Sunscreen SPF 55",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "20 Years to 60 Years · Female only"
      },
      "enrollment_count": 18,
      "start_date": "2025-08-11",
      "completion_date": "2025-11-12",
      "has_results": false,
      "last_update_posted_date": "2026-06-12",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "Irving, Texas",
      "locations": [
        {
          "city": "Irving",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07644871"
    },
    {
      "nct_id": "NCT04875715",
      "title": "Prospective Evaluation of Topical Almond Oil vs Hydroquinone",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Skin Pigmentation"
      ],
      "interventions": [
        {
          "name": "Almond Oil",
          "type": "OTHER"
        },
        {
          "name": "Hydroquinone Topical",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2021-07-01",
      "completion_date": "2026-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-12",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04875715"
    },
    {
      "nct_id": "NCT00616239",
      "title": "Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "20-30% Salicylic Acid peels to the right side of the face",
          "type": "DRUG"
        },
        {
          "name": "20-30% Salicylic Acid peels to the left side of the face",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2008-01",
      "completion_date": "2018-03",
      "has_results": true,
      "last_update_posted_date": "2020-08-10",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00616239"
    },
    {
      "nct_id": "NCT00669071",
      "title": "Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%",
          "type": "DRUG"
        },
        {
          "name": "Cetaphil® Moisturizing Cream as Inactive Control",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "18 Years to 74 Years"
      },
      "enrollment_count": 56,
      "start_date": "2008-01",
      "completion_date": "2008-10",
      "has_results": true,
      "last_update_posted_date": "2022-08-23",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 2,
      "location_summary": "La Jolla, California • Nashville, Tennessee",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00669071"
    },
    {
      "nct_id": "NCT00469183",
      "title": "Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 70,
      "start_date": "2006-05",
      "completion_date": "2007-04",
      "has_results": false,
      "last_update_posted_date": "2022-07-29",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 2,
      "location_summary": "Los Angeles, California • Dallas, Texas",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00469183"
    },
    {
      "nct_id": "NCT00927771",
      "title": "Azelaic Acid Versus Hydroquinone in Melasma",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melanosis"
      ],
      "interventions": [
        {
          "name": "azelaic acid gel",
          "type": "DRUG"
        },
        {
          "name": "hydroquinone cream",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Callender Center for Clinical Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 30,
      "start_date": "2009-06",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2009-06-25",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "Mitchellville, Maryland",
      "locations": [
        {
          "city": "Mitchellville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00927771"
    },
    {
      "nct_id": "NCT02977507",
      "title": "Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Lytera 2.0",
          "type": "OTHER"
        },
        {
          "name": "4% Hydroquinone Topical Cream",
          "type": "DRUG"
        },
        {
          "name": "SkinMedica Facial Cleanser",
          "type": "OTHER"
        },
        {
          "name": "SkinMedica Rejuvenative Moisturizer",
          "type": "OTHER"
        },
        {
          "name": "SkinMedica Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2016-12-13",
      "completion_date": "2017-10-09",
      "has_results": true,
      "last_update_posted_date": "2018-12-19",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02977507"
    },
    {
      "nct_id": "NCT00472966",
      "title": "Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Melasma"
      ],
      "interventions": [
        {
          "name": "Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2006-11",
      "completion_date": "2007-04",
      "has_results": false,
      "last_update_posted_date": "2022-07-29",
      "last_synced_at": "2026-09-11T10:22:22.047Z",
      "location_count": 1,
      "location_summary": "Boca Raton, Florida",
      "locations": [
        {
          "city": "Boca Raton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00472966"
    }
  ]
}