{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=inhaled+nitric+oxide+%28iNO%29&page=2",
    "query": {
      "intervention": "inhaled nitric oxide (iNO)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 54,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=inhaled+nitric+oxide+%28iNO%29&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=inhaled+nitric+oxide+%28iNO%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-08T22:49:04.104Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04398290",
      "title": "iNOPulse for COVID-19",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID-19",
        "Hypoxemia",
        "Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Inhaled nitric oxide (iNO)",
          "type": "DRUG"
        },
        {
          "name": "Nitrogen gas",
          "type": "DRUG"
        },
        {
          "name": "Oxygen gas",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Roger Alvarez",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-12-01",
      "completion_date": "2021-07-15",
      "has_results": false,
      "last_update_posted_date": "2020-08-19",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04398290"
    },
    {
      "nct_id": "NCT05801224",
      "title": "Vascular ARDS Recruitment After Inhaled Nitric Oxide",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome",
        "Ventilation Perfusion Mismatch"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 70,
      "start_date": "2026-07-10",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-10-02",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05801224"
    },
    {
      "nct_id": "NCT03727451",
      "title": "A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Pulmonary Hypertension",
        "Pulmonary Fibrosis",
        "Sarcoidosis, Pulmonary"
      ],
      "interventions": [
        {
          "name": "iNO",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Bellerophon",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 17,
      "start_date": "2019-01-30",
      "completion_date": "2022-06-15",
      "has_results": false,
      "last_update_posted_date": "2022-08-10",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 6,
      "location_summary": "Miami, Florida • Cincinnati, Ohio • Philadelphia, Pennsylvania + 3 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Falls Church",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03727451"
    },
    {
      "nct_id": "NCT01728220",
      "title": "Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Pulmonary Hypertension",
        "Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [
        {
          "name": "Inhaled NO delivered via INOpulse DS-C Device",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Placebo delivered via INOpulse DS-C Device",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Bellerophon Pulse Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 159,
      "start_date": "2012-12",
      "completion_date": "2014-07",
      "has_results": false,
      "last_update_posted_date": "2023-02-27",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 43,
      "location_summary": "Jasper, Alabama • Flagstaff, Arizona • Phoenix, Arizona + 35 more",
      "locations": [
        {
          "city": "Jasper",
          "state": "Alabama"
        },
        {
          "city": "Flagstaff",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Danbury",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01728220"
    },
    {
      "nct_id": "NCT00515281",
      "title": "Inhaled Nitric Oxide and Neuroprotection in Premature Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Prematurity",
        "Bronchopulmonary Dysplasia",
        "Intraventricular Hemorrhage",
        "Periventricular Leukomalacia"
      ],
      "interventions": [
        {
          "name": "inhaled nitric oxide",
          "type": "DRUG"
        },
        {
          "name": "oxygen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Hours",
        "maximum_age": "72 Hours",
        "sex": "ALL",
        "summary": "2 Hours to 72 Hours"
      },
      "enrollment_count": 273,
      "start_date": "2008-05",
      "completion_date": "2023-11-28",
      "has_results": true,
      "last_update_posted_date": "2024-10-17",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00515281"
    },
    {
      "nct_id": "NCT05213676",
      "title": "De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Congenital Diaphragmatic Hernia"
      ],
      "interventions": [
        {
          "name": "Inhaled Nitric Oxide (iNO) use",
          "type": "DRUG"
        },
        {
          "name": "De-implementation of Inhaled Nitric Oxide (iNO) use",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Months",
        "maximum_age": "1 Month",
        "sex": "ALL",
        "summary": "0 Months to 1 Month"
      },
      "enrollment_count": 600,
      "start_date": "2025-11-01",
      "completion_date": "2031-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-18",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 19,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Irvine, California + 16 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05213676"
    },
    {
      "nct_id": "NCT01748045",
      "title": "Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "inhaled nitric oxide",
          "type": "DRUG"
        },
        {
          "name": "Placebo Comparator - nitrogen gas",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Weeks",
        "maximum_age": "36 Weeks",
        "sex": "ALL",
        "summary": "30 Weeks to 36 Weeks"
      },
      "enrollment_count": 3,
      "start_date": "2013-03",
      "completion_date": "2014-07",
      "has_results": true,
      "last_update_posted_date": "2017-07-19",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01748045"
    },
    {
      "nct_id": "NCT00005776",
      "title": "Inhaled Nitric Oxide Study for Respiratory Failure in Newborns",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypertension, Pulmonary",
        "Persistent Fetal Circulation Syndrome",
        "Pneumonia, Aspiration",
        "Respiratory Distress Syndrome, Newborn",
        "Respiratory Insufficiency"
      ],
      "interventions": [
        {
          "name": "Inhaled nitric oxide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "14 Days",
        "sex": "ALL",
        "summary": "Up to 14 Days"
      },
      "enrollment_count": 235,
      "start_date": "1995-10",
      "completion_date": "1998-05",
      "has_results": false,
      "last_update_posted_date": "2017-09-26",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 11,
      "location_summary": "Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 8 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00005776"
    },
    {
      "nct_id": "NCT03023449",
      "title": "Diffuse Optical Monitoring With Inhaled Nitric Oxide",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Steven Messe",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 40,
      "start_date": "2017-04-04",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-08-24",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03023449"
    },
    {
      "nct_id": "NCT00570349",
      "title": "Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide for Inhalation",
          "type": "DRUG"
        },
        {
          "name": "Nitrogen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mallinckrodt",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2004-07",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2019-11-13",
      "last_synced_at": "2026-10-08T22:49:04.104Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00570349"
    }
  ]
}