{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=insulin%2C+4+units+three+times+daily",
    "query": {
      "intervention": "insulin, 4 units three times daily"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 6,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-10-06T11:31:52.378Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05206877",
      "title": "Topical Insulin for Glaucoma",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Glaucoma"
      ],
      "interventions": [
        {
          "name": "Insulin, 4 units",
          "type": "DRUG"
        },
        {
          "name": "Insulin, 20 units",
          "type": "DRUG"
        },
        {
          "name": "insulin, 4 units twice daily",
          "type": "DRUG"
        },
        {
          "name": "insulin, 20 units twice daily",
          "type": "DRUG"
        },
        {
          "name": "insulin, 4 units three times daily",
          "type": "DRUG"
        },
        {
          "name": "insulin, 20 units three times daily",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 52,
      "start_date": "2022-04-01",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-11-25",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05206877"
    },
    {
      "nct_id": "NCT02408120",
      "title": "Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Diabetes Mellitus, Type 2"
      ],
      "interventions": [
        {
          "name": "Insulin glargine",
          "type": "DRUG"
        },
        {
          "name": "Insulin aspart",
          "type": "DRUG"
        },
        {
          "name": "Supplemental insulin aspart",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 226,
      "start_date": "2015-10",
      "completion_date": "2019-12-11",
      "has_results": true,
      "last_update_posted_date": "2023-09-28",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 2,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02408120"
    },
    {
      "nct_id": "NCT02282423",
      "title": "PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Pre-study dietary and exercise instruction.",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Screening examination and oral glucose tolerance test",
          "type": "PROCEDURE"
        },
        {
          "name": "Euglycemic clamp",
          "type": "PROCEDURE"
        },
        {
          "name": "VO2max.",
          "type": "PROCEDURE"
        },
        {
          "name": "Acute exercise bout",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Percutaneous needle muscle biopsies",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "30 Years to 59 Years"
      },
      "enrollment_count": 26,
      "start_date": "2014-05",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-05-12",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 1,
      "location_summary": "Scottsdale, Arizona",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02282423"
    },
    {
      "nct_id": "NCT00609986",
      "title": "IV Insulin Protocol in Diabetes and Renal Transplantation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Kidney Transplantation",
        "Diabetes",
        "Hyperglycemia"
      ],
      "interventions": [
        {
          "name": "insulin",
          "type": "DRUG"
        },
        {
          "name": "NPH Insulin or glargine insulin and aspartame insulin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 104,
      "start_date": "2007-07",
      "completion_date": "2010-10",
      "has_results": true,
      "last_update_posted_date": "2013-09-06",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00609986"
    },
    {
      "nct_id": "NCT02127125",
      "title": "Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Insulin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Maltodextrin",
          "type": "DRUG"
        },
        {
          "name": "Synbiotic",
          "type": "DRUG"
        },
        {
          "name": "Sevelamer",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 69,
      "start_date": "2014-04-10",
      "completion_date": "2018-09-10",
      "has_results": true,
      "last_update_posted_date": "2020-09-11",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02127125"
    },
    {
      "nct_id": "NCT02124759",
      "title": "Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim 1)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Insulin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Sevelamer",
          "type": "DRUG"
        },
        {
          "name": "Synbiotic",
          "type": "DRUG"
        },
        {
          "name": "Maltodextrin",
          "type": "DRUG"
        },
        {
          "name": "High Fat diet",
          "type": "OTHER"
        },
        {
          "name": "Low Fat diet",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 20,
      "start_date": "2014-04-02",
      "completion_date": "2020-03-30",
      "has_results": true,
      "last_update_posted_date": "2021-10-15",
      "last_synced_at": "2026-10-06T11:31:52.378Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02124759"
    }
  ]
}