{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ketamine+25+mg", "query": { "intervention": "ketamine 25 mg" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 24, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ketamine+25+mg&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-18T14:16:25.146Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00721110", "title": "Lidocaine and Ketamine in Abdominal Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Abdominal Hysterectomy (& Wertheim)" ], "interventions": [ { "name": "Lidocaine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Ketamine + Lidocaine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "FEMALE", "summary": "18 Years to 75 Years · Female only" }, "enrollment_count": 64, "start_date": "2008-07", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2017-07-26", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "Mayfield Heights, Ohio", "locations": [ { "city": "Mayfield Heights", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00721110" }, { "nct_id": "NCT02950233", "title": "Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain, Postoperative" ], "interventions": [ { "name": "NMDA active", "type": "DRUG" }, { "name": "Steroid active", "type": "DRUG" }, { "name": "NMDA placebo", "type": "DRUG" }, { "name": "Steroid placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Population Health Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 27, "start_date": "2017-05-04", "completion_date": "2019-03-31", "has_results": false, "last_update_posted_date": "2020-01-18", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT02950233" }, { "nct_id": "NCT02996591", "title": "Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Nerve Block", "General Anesthesia", "Spinal Anesthesia", "Pain", "Postoperative Nausea and Vomiting" ], "interventions": [ { "name": "25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block", "type": "PROCEDURE" }, { "name": "10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block", "type": "PROCEDURE" }, { "name": "Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed", "type": "DRUG" }, { "name": "45-60 mg of 1.5% mepivacaine for spinal anesthesia", "type": "PROCEDURE" }, { "name": "LMA insertion + titrated propofol infusion + sevoflurane + ketamine 10 mg/hr for general anesthesia", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "Hospital for Special Surgery, New York", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 36, "start_date": "2017-01", "completion_date": "2017-05", "has_results": true, "last_update_posted_date": "2019-11-12", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02996591" }, { "nct_id": "NCT03039192", "title": "54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Esketamine", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Standard of Care", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 226, "start_date": "2017-06-09", "completion_date": "2018-12-18", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 17, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Garden Grove, California + 14 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Garden Grove", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03039192" }, { "nct_id": "NCT02493868", "title": "A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Treatment-Resistant" ], "interventions": [ { "name": "Esketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Duloxetine (Oral Antidepressant)", "type": "DRUG" }, { "name": "Escitalopram (Oral antidepressant)", "type": "DRUG" }, { "name": "Sertraline (Oral Antidepressant)", "type": "DRUG" }, { "name": "Venlafaxine Extended Release (XR) (Oral Antidepressant)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 719, "start_date": "2015-10-01", "completion_date": "2018-02-16", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 53, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Anaheim, California + 50 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Glendale", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02493868" }, { "nct_id": "NCT07227454", "title": "A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Esketamine", "type": "DRUG" }, { "name": "Midazolam", "type": "DRUG" }, { "name": "Oral Placebo", "type": "OTHER" }, { "name": "Intranasal Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "12 Years to 17 Years" }, "enrollment_count": 258, "start_date": "2026-01-08", "completion_date": "2031-09-15", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 10, "location_summary": "Birmingham, Alabama • Washington D.C., District of Columbia • Atlanta, Georgia + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Evanston", "state": "Illinois" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07227454" }, { "nct_id": "NCT01833897", "title": "NMDA Antagonists in Bipolar Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Standard of Care", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "D-cycloserine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "New York State Psychiatric Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 8, "start_date": "2013-03", "completion_date": "2016-03", "has_results": true, "last_update_posted_date": "2016-06-01", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01833897" }, { "nct_id": "NCT06835504", "title": "Morphine or Ketamine for Analgesia", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Abdominal Pain", "Isolated Extremity Fracture", "Pain", "Pediatrics" ], "interventions": [ { "name": "Ketamine hydrochloride", "type": "DRUG" }, { "name": "Morphine sulphate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 1010, "start_date": "2026-09-01", "completion_date": "2030-02-28", "has_results": false, "last_update_posted_date": "2026-06-09", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 8, "location_summary": "Los Angeles, California • Sacramento, California • Wilmington, Delaware + 5 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Wilmington", "state": "Delaware" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06835504" }, { "nct_id": "NCT03081416", "title": "\"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department\"", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Headache", "Intranasal Ketamine" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Normal saline", "type": "DRUG" }, { "name": "Metoclopramide", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Benadryl", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Brooke Army Medical Center", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 80, "start_date": "2016-05", "completion_date": "2017-10", "has_results": false, "last_update_posted_date": "2018-01-18", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03081416" }, { "nct_id": "NCT01158820", "title": "Alternative Sedation During Bronchoscopy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Sedation" ], "interventions": [ { "name": "Dexmedetomidine load", "type": "DRUG" }, { "name": "Ketamine load", "type": "DRUG" }, { "name": "Midazolam load", "type": "DRUG" }, { "name": "Fentanyl load", "type": "DRUG" }, { "name": "Dexmedetomidine maintenance", "type": "DRUG" }, { "name": "Ketamine maintenance", "type": "DRUG" }, { "name": "Midazolam demand", "type": "DRUG" }, { "name": "Fentanyl demand", "type": "DRUG" }, { "name": "Benadryl demand", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 50, "start_date": "2010-06", "completion_date": "2012-05", "has_results": true, "last_update_posted_date": "2019-02-26", "last_synced_at": "2026-09-18T14:16:25.146Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01158820" } ] }