{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=local+tetracycline", "query": { "intervention": "local tetracycline" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=local+tetracycline&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-15T05:31:28.800Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00016835", "title": "Treating Periodontal Infection: Effects on Glycemic", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Periodontal Disease", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Supra-gingival scaling and placebo", "type": "PROCEDURE" }, { "name": "Subgingival scaling and metronidazole", "type": "PROCEDURE" }, { "name": "Subgingival scaling and doxycycline", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2001-10-17", "completion_date": "2004-09-03", "has_results": false, "last_update_posted_date": "2017-07-19", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT00016835" }, { "nct_id": "NCT05100654", "title": "Collaborative Urological Prosthetics Investigation Directive Research Group", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Erectile Dysfunction", "Penile Prosthesis Infection" ], "interventions": [ { "name": "Doxycycline", "type": "DRUG" }, { "name": "Ciprofloxacin", "type": "DRUG" }, { "name": "Augmentin", "type": "DRUG" }, { "name": "Bactrim", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "90 Years", "sex": "MALE", "summary": "35 Years to 90 Years · Male only" }, "enrollment_count": 800, "start_date": "2022-04-22", "completion_date": "2028-01-01", "has_results": false, "last_update_posted_date": "2026-02-02", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05100654" }, { "nct_id": "NCT05701254", "title": "Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Type 1 Diabetes", "Osteopenia", "Bone Loss", "Fractures, Bone" ], "interventions": [ { "name": "Transilial bone biopsy", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Creighton University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "FEMALE", "summary": "50 Years and older · Female only" }, "enrollment_count": 80, "start_date": "2019-06-18", "completion_date": "2025-01", "has_results": false, "last_update_posted_date": "2024-09-25", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 1, "location_summary": "Omaha, Nebraska", "locations": [ { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT05701254" }, { "nct_id": "NCT06120140", "title": "Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "interventions": [ { "name": "Amivantamab IV", "type": "DRUG" }, { "name": "Amivantamab SC", "type": "DRUG" }, { "name": "Lazertinib", "type": "DRUG" }, { "name": "Doxycycline", "type": "DRUG" }, { "name": "Minocycline", "type": "DRUG" }, { "name": "Clindamycin", "type": "DRUG" }, { "name": "Chlorhexidine", "type": "DRUG" }, { "name": "Noncomedogenic skin moisturizer", "type": "OTHER" }, { "name": "Ruxolitinib", "type": "OTHER" }, { "name": "Tacrolimus", "type": "OTHER" }, { "name": "Zinc gluconate", "type": "DRUG" }, { "name": "Propranolol", "type": "DRUG" }, { "name": "Timolol", "type": "DRUG" }, { "name": "Clobetasol", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 305, "start_date": "2024-02-16", "completion_date": "2030-06-30", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 28, "location_summary": "Chandler, Arizona • Duarte, California • Fullerton, California + 25 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Duarte", "state": "California" }, { "city": "Fullerton", "state": "California" }, { "city": "Glendale", "state": "California" }, { "city": "Huntington Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06120140" }, { "nct_id": "NCT02576652", "title": "Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Osteoporosis" ], "interventions": [ { "name": "Tetracycline", "type": "OTHER" }, { "name": "Demeclocycline", "type": "OTHER" }, { "name": "Total Hip Replacement", "type": "PROCEDURE" } ], "intervention_types": [ "OTHER", "PROCEDURE" ], "sponsor": "Amgen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "50 Years to 100 Years" }, "enrollment_count": 6, "start_date": "2015-12-22", "completion_date": "2017-12-18", "has_results": true, "last_update_posted_date": "2019-04-26", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 2, "location_summary": "West Haverstraw, New York", "locations": [ { "city": "West Haverstraw", "state": "New York" }, { "city": "West Haverstraw", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02576652" }, { "nct_id": "NCT01098448", "title": "Control of Periodontal Infections", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Periodontitis" ], "interventions": [ { "name": "scaling and root planing", "type": "OTHER" }, { "name": "local tetracycline", "type": "DRUG" }, { "name": "systemic metronidazole and amoxicillin", "type": "DRUG" }, { "name": "surgery", "type": "OTHER" }, { "name": "local antibiotics and systemic metronidazole and amoxicillin", "type": "DRUG" }, { "name": "local tetracycline and periodontal surgery", "type": "OTHER" }, { "name": "periodontal surgery and systemic metronidazole and amoxicillin", "type": "OTHER" }, { "name": "surgery, local tetracycline, systemic metronidazole and amoxicillin", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "The Forsyth Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "20 Years", "maximum_age": null, "sex": "ALL", "summary": "20 Years and older" }, "enrollment_count": 187, "start_date": "1999-09", "completion_date": "2004-12", "has_results": false, "last_update_posted_date": "2010-04-02", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01098448" }, { "nct_id": "NCT02541032", "title": "PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Periodontal Disease", "Stroke", "TIA" ], "interventions": [ { "name": "Intensive dental treatment", "type": "PROCEDURE" }, { "name": "Standard dental treatment", "type": "PROCEDURE" }, { "name": "Arestin", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "University of South Carolina", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 400, "start_date": "2015-12", "completion_date": "2020-06", "has_results": false, "last_update_posted_date": "2019-04-18", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 2, "location_summary": "Chapel Hill, North Carolina • Columbia, South Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Columbia", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02541032" }, { "nct_id": "NCT01647282", "title": "Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Moderate to Advanced Chronic Periodontitis" ], "interventions": [ { "name": "locally-applied minocycline HCl (1 mg)", "type": "DRUG" }, { "name": "scaling and root planing (Sc/RP)", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "University of Nebraska", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "40 Years to 85 Years" }, "enrollment_count": 60, "start_date": "2012-10-01", "completion_date": "2015-12-01", "has_results": true, "last_update_posted_date": "2023-09-25", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 2, "location_summary": "Lincoln, Nebraska • Omaha, Nebraska", "locations": [ { "city": "Lincoln", "state": "Nebraska" }, { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT01647282" }, { "nct_id": "NCT03511118", "title": "Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Lactating Women on Select DOI", "Breastfed Infants of Mothers on Select DOI" ], "interventions": [ { "name": "Tranexamic acid (TXA)", "type": "DRUG" }, { "name": "labetalol", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "nifedipine", "type": "DRUG" }, { "name": "clindamycin", "type": "DRUG" }, { "name": "oxycodone", "type": "DRUG" }, { "name": "azithromycin", "type": "DRUG" }, { "name": "escitalopram", "type": "DRUG" }, { "name": "sertraline", "type": "DRUG" }, { "name": "ondansetron", "type": "DRUG" }, { "name": "Ciprofloxacin", "type": "DRUG" }, { "name": "Doxycycline", "type": "DRUG" }, { "name": "Levofloxacin", "type": "DRUG" }, { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Sumatriptan", "type": "DRUG" }, { "name": "Citalopram", "type": "DRUG" }, { "name": "Cyclobenzaprine", "type": "DRUG" }, { "name": "Furosemide", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Hydroxyurea", "type": "DRUG" }, { "name": "Rosuvastatin", "type": "DRUG" }, { "name": "Topiramate", "type": "DRUG" }, { "name": "Trazodone", "type": "DRUG" }, { "name": "Valganciclovir", "type": "DRUG" }, { "name": "Venlafaxine", "type": "DRUG" }, { "name": "Verapamil", "type": "DRUG" }, { "name": "Remdesivir", "type": "DRUG" }, { "name": "Anakinra", "type": "DRUG" }, { "name": "Tocilizumab", "type": "DRUG" }, { "name": "Fluvoxamine", "type": "DRUG" }, { "name": "Amoxicillin", "type": "DRUG" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "Duloxetine", "type": "DRUG" }, { "name": "Hydrocodone", "type": "DRUG" }, { "name": "Levetiracetam", "type": "DRUG" }, { "name": "Paroxetine", "type": "DRUG" }, { "name": "Buprenorphine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 1600, "start_date": "2018-10-04", "completion_date": "2028-07-31", "has_results": false, "last_update_posted_date": "2026-07-29", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 20, "location_summary": "La Jolla, California • Loma Linda, California • Chicago, Illinois + 15 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT03511118" }, { "nct_id": "NCT00066066", "title": "Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Periodontitis", "Periodontal Diseases" ], "interventions": [ { "name": "Scaling and root planing", "type": "PROCEDURE" }, { "name": "Metronidazole", "type": "DRUG" }, { "name": "Amoxicillin", "type": "DRUG" }, { "name": "Doxycycline", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "The Forsyth Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "20 Years", "maximum_age": null, "sex": "ALL", "summary": "20 Years and older" }, "enrollment_count": 146, "start_date": "2003-07", "completion_date": "2009-07", "has_results": true, "last_update_posted_date": "2013-04-22", "last_synced_at": "2026-09-15T05:31:28.800Z", "location_count": 1, "location_summary": "Cambridge, Massachusetts", "locations": [ { "city": "Cambridge", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00066066" } ] }