{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=loperamide", "query": { "intervention": "loperamide" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 48, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=loperamide&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-06T12:32:10.237Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01391962", "title": "Sunitinib or Cediranib for Alveolar Soft Part Sarcoma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Sarcoma, Alveolar Soft Part" ], "interventions": [ { "name": "Cediranib", "type": "DRUG" }, { "name": "Sunitinib", "type": "DRUG" }, { "name": "Prochlorperazine", "type": "OTHER" }, { "name": "Promethazine", "type": "OTHER" }, { "name": "Benzodiazepine", "type": "OTHER" }, { "name": "Filgrastim", "type": "OTHER" }, { "name": "Sargramostim", "type": "OTHER" }, { "name": "Lomotil", "type": "OTHER" }, { "name": "Loperamide", "type": "OTHER" }, { "name": "Vitamin B6", "type": "OTHER" }, { "name": "Aquaphor", "type": "OTHER" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Levothyroxine", "type": "DRUG" }, { "name": "Warfarin", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "120 Years", "sex": "ALL", "summary": "16 Years to 120 Years" }, "enrollment_count": 34, "start_date": "2011-07-18", "completion_date": "2026-01-16", "has_results": true, "last_update_posted_date": "2026-02-02", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01391962" }, { "nct_id": "NCT02057133", "title": "A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Breast Neoplasms" ], "interventions": [ { "name": "LY2835219", "type": "DRUG" }, { "name": "Letrozole", "type": "DRUG" }, { "name": "Anastrozole", "type": "DRUG" }, { "name": "Tamoxifen", "type": "DRUG" }, { "name": "Exemestane", "type": "DRUG" }, { "name": "Everolimus", "type": "DRUG" }, { "name": "Trastuzumab", "type": "DRUG" }, { "name": "LY3023414", "type": "DRUG" }, { "name": "Fulvestrant", "type": "DRUG" }, { "name": "Pertuzumab", "type": "DRUG" }, { "name": "Loperamide", "type": "DRUG" }, { "name": "Endocrine therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 198, "start_date": "2014-03-10", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2026-01-26", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 13, "location_summary": "Rogers, Arkansas • La Jolla, California • Boston, Massachusetts + 7 more", "locations": [ { "city": "Rogers", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02057133" }, { "nct_id": "NCT02257879", "title": "DHB Supplement Interaction Study", "overall_status": "WITHDRAWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Healthy Volunteers" ], "interventions": [], "intervention_types": [], "sponsor": "National Institute of Environmental Health Sciences (NIEHS)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 0, "start_date": "2014-10-03", "completion_date": "2020-04-20", "has_results": false, "last_update_posted_date": "2020-04-24", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 1, "location_summary": "Research Triangle Park, North Carolina", "locations": [ { "city": "Research Triangle Park", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02257879" }, { "nct_id": "NCT01739634", "title": "The Efficacy of CASAD in Patients With Diarrhea Related to Medullary Thyroid Cancer", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diarrhea", "Medullary Thyroid Cancer" ], "interventions": [ { "name": "CASAD", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Salient Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 10, "start_date": "2012-11", "completion_date": "2013-12", "has_results": false, "last_update_posted_date": "2012-12-03", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01739634" }, { "nct_id": "NCT06865677", "title": "Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical Carcinomas", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Recurrent Platinum Resistant Epithelial Ovarian Carcinoma", "Recurrent Epithelial Endometrial Carcinoma", "Recurrent Epithelial Cervical Carcinoma" ], "interventions": [ { "name": "Sacituzumab Govitecan", "type": "DRUG" }, { "name": "EKG", "type": "DIAGNOSTIC_TEST" }, { "name": "Brain MRI", "type": "DIAGNOSTIC_TEST" }, { "name": "CT scans", "type": "DIAGNOSTIC_TEST" }, { "name": "Tumor biopsy", "type": "PROCEDURE" }, { "name": "Loperamide", "type": "DRUG" }, { "name": "Octreotide", "type": "DRUG" }, { "name": "Diphenoxylate/Atropine", "type": "DRUG" }, { "name": "Antiemetics", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DIAGNOSTIC_TEST", "PROCEDURE" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "120 Years", "sex": "FEMALE", "summary": "18 Years to 120 Years · Female only" }, "enrollment_count": 2, "start_date": "2025-06-09", "completion_date": "2025-07-01", "has_results": true, "last_update_posted_date": "2026-01-21", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT06865677" }, { "nct_id": "NCT00806299", "title": "Loperamide Grapefruit Juice Interaction PK Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Drug Interaction" ], "interventions": [ { "name": "Loperamide / Red Grapefruit Juice", "type": "DRUG" }, { "name": "Loperamide/ White Grapefruit Juice", "type": "DRUG" }, { "name": "Loperamide / Pink Grapefruit Juice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "59 Years", "sex": "ALL", "summary": "18 Years to 59 Years" }, "enrollment_count": 33, "start_date": "2008-11", "completion_date": "2008-11", "has_results": false, "last_update_posted_date": "2011-10-06", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 1, "location_summary": "Fargo, North Dakota", "locations": [ { "city": "Fargo", "state": "North Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT00806299" }, { "nct_id": "NCT02959983", "title": "Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea in Patients With Inadequate Control of Symptoms With Prior Loperamide Use", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Irritable Bowel Syndrome With Diarrhea" ], "interventions": [ { "name": "Eluxadoline", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allergan", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 346, "start_date": "2016-10-25", "completion_date": "2018-01-22", "has_results": true, "last_update_posted_date": "2019-02-15", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 76, "location_summary": "Huntsville, Alabama • Saraland, Alabama • Phoenix, Arizona + 66 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Saraland", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "North Little Rock", "state": "Arkansas" }, { "city": "Carmichael", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02959983" }, { "nct_id": "NCT02242656", "title": "A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Short Bowel Syndrome", "Short Gut Syndrome", "SBS", "Short Bowel", "Short Gut" ], "interventions": [ { "name": "Opium Tincture USP Deodorized", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Marathon Pharmaceuticals, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2014-12", "completion_date": null, "has_results": false, "last_update_posted_date": "2015-02-18", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 5, "location_summary": "Chicago, Illinois • Indianapolis, Indiana • Cleveland, Ohio + 2 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Cleveland", "state": "Ohio" }, { "city": "Lima", "state": "Ohio" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02242656" }, { "nct_id": "NCT01814553", "title": "ADAM-Afatinib Diarrhea Assessment and Management", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "interventions": [ { "name": "afatinib", "type": "DRUG" }, { "name": "loperamide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2013-04", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2016-10-31", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 12, "location_summary": "Santa Rosa, California • Orlando, Florida • Port Saint Lucie, Florida + 7 more", "locations": [ { "city": "Santa Rosa", "state": "California" }, { "city": "Orlando", "state": "Florida" }, { "city": "Port Saint Lucie", "state": "Florida" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "Skokie", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01814553" }, { "nct_id": "NCT00650637", "title": "A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diarrhea" ], "interventions": [ { "name": "Calcium Carbonate", "type": "DRUG" }, { "name": "nelfinavir", "type": "DRUG" }, { "name": "lamivudine", "type": "DRUG" }, { "name": "loperamide", "type": "DRUG" }, { "name": "Calcium carbonate not administered", "type": "OTHER" }, { "name": "lamivudine + zidovudine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 17, "start_date": "2003-01", "completion_date": "2003-08", "has_results": false, "last_update_posted_date": "2011-06-08", "last_synced_at": "2026-09-06T12:32:10.237Z", "location_count": 6, "location_summary": "Birmingham, Alabama • Fort Lauderdale, Florida • New York, New York + 3 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Fort Lauderdale", "state": "Florida" }, { "city": "New York", "state": "New York" }, { "city": "Huntersville", "state": "North Carolina" }, { "city": "Austin", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00650637" } ] }