{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=losartan+and+HCTZ", "query": { "intervention": "losartan and HCTZ" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=losartan+and+HCTZ&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-29T11:26:08.024Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01271374", "title": "Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "amlodipine and olmesartan", "type": "DRUG" }, { "name": "losartan and HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "InVasc Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 80, "start_date": "2010-04", "completion_date": "2011-12", "has_results": false, "last_update_posted_date": "2011-05-05", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Tucker, Georgia", "locations": [ { "city": "Tucker", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01271374" }, { "nct_id": "NCT00223717", "title": "Treatment of Supine Hypertension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Clonidine", "type": "DRUG" }, { "name": "Nitroglycerin transdermal", "type": "DRUG" }, { "name": "Dipyridamole/ Aspirin (Aggrenox)", "type": "DRUG" }, { "name": "Desmopressin (DDAVP)", "type": "DRUG" }, { "name": "Sildenafil", "type": "DRUG" }, { "name": "Nifedipine", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Bosentan", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" }, { "name": "Eplerenone", "type": "DRUG" }, { "name": "guanfacine", "type": "DRUG" }, { "name": "L-arginine", "type": "DIETARY_SUPPLEMENT" }, { "name": "captopril", "type": "DRUG" }, { "name": "carbidopa", "type": "DRUG" }, { "name": "losartan", "type": "DRUG" }, { "name": "metoprolol tartrate", "type": "DRUG" }, { "name": "nebivolol hydrochloride", "type": "DRUG" }, { "name": "prazosin hydrochloride", "type": "DRUG" }, { "name": "tamsulosin hydrochloride", "type": "DRUG" }, { "name": "Head-up tilt.", "type": "OTHER" }, { "name": "aliskiren", "type": "DRUG" }, { "name": "Local heat stress", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 152, "start_date": "2001-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223717" }, { "nct_id": "NCT00673790", "title": "The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Nebivolol with concomitant losartan or lisinopril", "type": "DRUG" }, { "name": "HCTZ with concomitant losartan or lisinopril", "type": "DRUG" }, { "name": "Placebo with concomitant losartan or lisinopril", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 537, "start_date": "2008-05-15", "completion_date": "2010-07-09", "has_results": true, "last_update_posted_date": "2020-02-26", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 88, "location_summary": "Athens, Alabama • Birmingham, Alabama • Huntsville, Alabama + 75 more", "locations": [ { "city": "Athens", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00673790" }, { "nct_id": "NCT01891513", "title": "ACE Inhibitors Combined With Exercise for Seniors - Pilot Study", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hypertension", "Aging" ], "interventions": [ { "name": "Exercise", "type": "BEHAVIORAL" }, { "name": "ACE inhibitor + exercise", "type": "DRUG" }, { "name": "Thiazide diuretic + exercise", "type": "DRUG" }, { "name": "Angiotensin receptor blocker + exercise", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 104, "start_date": "2014-01", "completion_date": "2017-06", "has_results": false, "last_update_posted_date": "2017-07-05", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01891513" }, { "nct_id": "NCT02278471", "title": "The SCCS Polypill Pilot Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension", "Hyperlipidemia" ], "interventions": [ { "name": "Polypill (atorvastatin, amlodipine, losartan, and hydrochlorothiazide)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "45 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "45 Years to 75 Years" }, "enrollment_count": 303, "start_date": "2015-12", "completion_date": "2018-06-27", "has_results": true, "last_update_posted_date": "2021-05-14", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Mobile, Alabama", "locations": [ { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT02278471" }, { "nct_id": "NCT01087749", "title": "Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Kidney Disease" ], "interventions": [ { "name": "Propranolol", "type": "DRUG" }, { "name": "Losartan", "type": "DRUG" }, { "name": "Eprosartan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 24, "start_date": "2010-03", "completion_date": "2012-12", "has_results": false, "last_update_posted_date": "2013-05-30", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01087749" }, { "nct_id": "NCT02744456", "title": "N-of-1 Trials for Blood Pressure Medications in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Hypertension", "High Blood Pressure" ], "interventions": [ { "name": "Losartan", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "21 Years to 80 Years" }, "enrollment_count": 10, "start_date": "2014-08-01", "completion_date": "2017-12-31", "has_results": false, "last_update_posted_date": "2019-03-26", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02744456" }, { "nct_id": "NCT04467931", "title": "ACEI or ARB and COVID-19 Severity and Mortality in US Veterans", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hypertension", "COVID" ], "interventions": [ { "name": "ACEI/ARB", "type": "DRUG" }, { "name": "Non-ACEI/ARB", "type": "DRUG" }, { "name": "ACEI", "type": "DRUG" }, { "name": "ARB", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Utah", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 22213, "start_date": "2020-01-19", "completion_date": "2020-12-31", "has_results": false, "last_update_posted_date": "2021-04-28", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT04467931" }, { "nct_id": "NCT00931710", "title": "Valsartan/Amlodipine As Compared to Losartan Treatment in Stage 2 Systolic Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Stage 2 Systolic Hypertension" ], "interventions": [ { "name": "valsartan, amlodipine, HCTZ", "type": "DRUG" }, { "name": "Losartan, HCTZ followed by valsartan, amlodipine, HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 488, "start_date": "2009-07", "completion_date": "2010-01", "has_results": true, "last_update_posted_date": "2011-03-07", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "East Hanover, New Jersey", "locations": [ { "city": "East Hanover", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00931710" }, { "nct_id": "NCT03461003", "title": "N-of-1 Trials In Children With Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pediatric Hypertension" ], "interventions": [ { "name": "NICHE method", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Lisinopril", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Losartan", "type": "DRUG" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "22 Years", "sex": "ALL", "summary": "10 Years to 22 Years" }, "enrollment_count": 49, "start_date": "2018-04-02", "completion_date": "2021-05-02", "has_results": true, "last_update_posted_date": "2022-09-09", "last_synced_at": "2026-09-29T11:26:08.024Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03461003" } ] }