{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low+dexmedetomidine%2C+low+propofol",
    "query": {
      "intervention": "low dexmedetomidine, low propofol"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-30T18:31:53.738Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00671931",
      "title": "Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Scoliosis"
      ],
      "interventions": [
        {
          "name": "low dexmedetomidine, low propofol",
          "type": "DRUG"
        },
        {
          "name": "high dexmedetomidine, low propofol",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "10 Years to 25 Years"
      },
      "enrollment_count": 44,
      "start_date": "2007-04",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2013-08-23",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00671931"
    },
    {
      "nct_id": "NCT02633241",
      "title": "A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Epilepsy",
        "Cerebral Palsy",
        "Developmental Delay"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine bolus and high infusion-Propofol",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidine bolus and low infusion-Propofol",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidine bolus only - Propofol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Joseph Cravero",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "1 Year to 12 Years"
      },
      "enrollment_count": 71,
      "start_date": "2017-03-02",
      "completion_date": "2022-09-06",
      "has_results": true,
      "last_update_posted_date": "2023-06-27",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02633241"
    },
    {
      "nct_id": "NCT07705022",
      "title": "Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Healthy",
        "Covert Consciousness"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine (+propofol as indicated)",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 60,
      "start_date": "2026-08-07",
      "completion_date": "2028-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07705022"
    },
    {
      "nct_id": "NCT04237792",
      "title": "Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "MRI Sedation"
      ],
      "interventions": [
        {
          "name": "dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "propofol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "1 Month to 16 Years"
      },
      "enrollment_count": 128,
      "start_date": "2020-02-18",
      "completion_date": "2021-11-30",
      "has_results": true,
      "last_update_posted_date": "2022-11-16",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 16,
      "location_summary": "Little Rock, Arkansas • Palo Alto, California • Sacramento, California + 12 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "West Palm Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04237792"
    },
    {
      "nct_id": "NCT01736020",
      "title": "Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Propofol",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        },
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Southern California Institute for Research and Education",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 293,
      "start_date": "2009-09",
      "completion_date": "2017-04",
      "has_results": false,
      "last_update_posted_date": "2016-10-13",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01736020"
    },
    {
      "nct_id": "NCT03378973",
      "title": "The Effects of Dexmedetomidine Dose on Motor Evoked Potentials",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Spinal Fusion"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 7,
      "start_date": "2018-11-28",
      "completion_date": "2019-10-17",
      "has_results": true,
      "last_update_posted_date": "2020-04-28",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03378973"
    },
    {
      "nct_id": "NCT07369128",
      "title": "Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "MRI Sedation",
        "Pediatric Sedation",
        "Propofol Dosage",
        "Emergence Delirium, Anesthesia",
        "Recovery Time",
        "Dexmedetomidine"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine (IV) 0.5 mcg/kg",
          "type": "DRUG"
        },
        {
          "name": "Propofol (IV) 2-4 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidine (IV) 1 mcg/kg",
          "type": "DRUG"
        },
        {
          "name": "Propofol (IV) 1-2 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Propofol (IV) Infusion 250 mcg/kg/min",
          "type": "DRUG"
        },
        {
          "name": "Propofol (IV) Infusion 150 mcg/kg/min",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "1 Year to 12 Years"
      },
      "enrollment_count": 105,
      "start_date": "2026-06-30",
      "completion_date": "2028-03",
      "has_results": false,
      "last_update_posted_date": "2026-09-21",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07369128"
    },
    {
      "nct_id": "NCT07221539",
      "title": "Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mental Function"
      ],
      "interventions": [
        {
          "name": "Propofol for fMRI",
          "type": "PROCEDURE"
        },
        {
          "name": "Dexmedetomidine for fMRI",
          "type": "PROCEDURE"
        },
        {
          "name": "Dorsolateral prefrontal cortex (DLPFC) pulsation",
          "type": "DEVICE"
        },
        {
          "name": "Anterior insular cortex (AIC) pulsation",
          "type": "DEVICE"
        },
        {
          "name": "Central thalamus (CT) pulsation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 168,
      "start_date": "2025-10-24",
      "completion_date": "2030-10",
      "has_results": false,
      "last_update_posted_date": "2025-10-28",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07221539"
    },
    {
      "nct_id": "NCT03263117",
      "title": "SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Sedation",
          "type": "DRUG"
        },
        {
          "name": "General Anesthesia (GA)",
          "type": "DRUG"
        },
        {
          "name": "Intra-arterial Thrombectomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 260,
      "start_date": "2018-07-01",
      "completion_date": "2023-04-22",
      "has_results": true,
      "last_update_posted_date": "2025-11-26",
      "last_synced_at": "2026-09-30T18:31:53.738Z",
      "location_count": 11,
      "location_summary": "Indianapolis, Indiana • Iowa City, Iowa • Louisville, Kentucky + 6 more",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Rochester",
          "state": "New York"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03263117"
    }
  ]
}