{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low+dose+Nicotine",
    "query": {
      "intervention": "low dose Nicotine"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 46,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low+dose+Nicotine&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T06:40:19.295Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06609109",
      "title": "Effect of Cannabis on E-Cigarette Use Behavior",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cannabis Use",
        "Tobacco Use",
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "THC High Dose",
          "type": "DRUG"
        },
        {
          "name": "THC Low Dose",
          "type": "DRUG"
        },
        {
          "name": "THC 0mg",
          "type": "DRUG"
        },
        {
          "name": "E-Cigarette Full Nicotine",
          "type": "DRUG"
        },
        {
          "name": "E-Cigarette Placebo Nicotine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2025-03-19",
      "completion_date": "2029-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06609109"
    },
    {
      "nct_id": "NCT01303861",
      "title": "Concurrent Bupropion / Varenicline for Smoking Cessation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Nicotine patches",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Inhaler",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 702,
      "start_date": "2011-03",
      "completion_date": "2013-07",
      "has_results": true,
      "last_update_posted_date": "2014-08-06",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 4,
      "location_summary": "Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01303861"
    },
    {
      "nct_id": "NCT02162849",
      "title": "Reward Sensitivity and Pharmacotherapy for Smoking Cessation",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Tobacco Use Cessation"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo Tablet",
          "type": "DRUG"
        },
        {
          "name": "Questionnaires",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Counseling Sessions",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Lab Session",
          "type": "OTHER"
        },
        {
          "name": "Saliva Test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 204,
      "start_date": "2015-12-14",
      "completion_date": "2028-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-07-16",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02162849"
    },
    {
      "nct_id": "NCT01636323",
      "title": "Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mclean Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 300,
      "start_date": "2008-12",
      "completion_date": "2016-12",
      "has_results": false,
      "last_update_posted_date": "2013-01-15",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Belmont, Massachusetts",
      "locations": [
        {
          "city": "Belmont",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01636323"
    },
    {
      "nct_id": "NCT06609083",
      "title": "Effect of Cannabis on Cigarette Use Behavior",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cannabis Use",
        "Tobacco Use",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "THC 30mg",
          "type": "DRUG"
        },
        {
          "name": "THC 5mg",
          "type": "DRUG"
        },
        {
          "name": "THC 0mg",
          "type": "DRUG"
        },
        {
          "name": "Cigarette Full Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Cigarette Reduced Nicotine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2025-01-22",
      "completion_date": "2029-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06609083"
    },
    {
      "nct_id": "NCT00108342",
      "title": "Nicotine Delivery Systems: Research & Treatment",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Nicotine gum - 2 mg and 4 mg",
          "type": "DRUG"
        },
        {
          "name": "Nicotine lozenges - 2 mg and 4 mg",
          "type": "DRUG"
        },
        {
          "name": "Nicotine inhaler (4 mg yield) - low and high \"dosage\" by frequency of puffing",
          "type": "DRUG"
        },
        {
          "name": "Computer learning",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 25,
      "start_date": "2007-10",
      "completion_date": "2009-12",
      "has_results": true,
      "last_update_posted_date": "2014-06-04",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "West Los Angeles, California",
      "locations": [
        {
          "city": "West Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00108342"
    },
    {
      "nct_id": "NCT01395797",
      "title": "Pioglitazone for Heroin and for Nicotine Dependence",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Heroin Dependence",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "PIO",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 82,
      "start_date": "2011-03",
      "completion_date": "2014-06",
      "has_results": true,
      "last_update_posted_date": "2017-07-13",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01395797"
    },
    {
      "nct_id": "NCT03593538",
      "title": "Effects of Metformin During Nicotine Withdrawal",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Smoking",
        "HIV-1-infection"
      ],
      "interventions": [
        {
          "name": "Metformin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 80,
      "start_date": "2016-04-01",
      "completion_date": "2020-03-13",
      "has_results": true,
      "last_update_posted_date": "2021-03-26",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03593538"
    },
    {
      "nct_id": "NCT01372254",
      "title": "Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Cigarette Smoking",
        "Drug Use"
      ],
      "interventions": [
        {
          "name": "Standard Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "BAD-AS",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Maryland, College Park",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 96,
      "start_date": "2011-12",
      "completion_date": "2015-05",
      "has_results": true,
      "last_update_posted_date": "2022-05-18",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01372254"
    },
    {
      "nct_id": "NCT02420327",
      "title": "Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor"
      ],
      "interventions": [
        {
          "name": "Placebo patch & placebo capsule",
          "type": "DRUG"
        },
        {
          "name": "Placebo patch & galantamine capsule",
          "type": "DRUG"
        },
        {
          "name": "Nicotine patch & placebo capsule",
          "type": "DRUG"
        },
        {
          "name": "Nicotine patch and galantamine capsule",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 43,
      "start_date": "2014-09",
      "completion_date": "2017-03",
      "has_results": true,
      "last_update_posted_date": "2019-11-04",
      "last_synced_at": "2026-09-03T06:40:19.295Z",
      "location_count": 1,
      "location_summary": "Catonsville, Maryland",
      "locations": [
        {
          "city": "Catonsville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02420327"
    }
  ]
}