{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low-calorie+%28low-fat%29+diet&page=2",
    "query": {
      "intervention": "low-calorie (low-fat) diet",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 148,
    "total_pages": 15,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low-calorie+%28low-fat%29+diet&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=low-calorie+%28low-fat%29+diet&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-07T13:34:28.954Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01474785",
      "title": "RYGB and the Gastric Adipose Axis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Obesity"
      ],
      "interventions": [
        {
          "name": "human ghrelin",
          "type": "DRUG"
        },
        {
          "name": "very low calorie diet",
          "type": "OTHER"
        },
        {
          "name": "Hyperinsulinemic/Euglycemic Clamp",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 49,
      "start_date": "2012-01",
      "completion_date": "2015-07",
      "has_results": false,
      "last_update_posted_date": "2018-05-21",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01474785"
    },
    {
      "nct_id": "NCT05290064",
      "title": "Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Diet",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Ultra-processed food, high energy density (UPF HL)",
          "type": "OTHER"
        },
        {
          "name": "Ultra-processed food, both low (UPF LL)",
          "type": "OTHER"
        },
        {
          "name": "Ultra-processed food, both high (UPF HH)",
          "type": "OTHER"
        },
        {
          "name": "Unprocessed food diet (UNF LL)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Institutes of Health Clinical Center (CC)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 38,
      "start_date": "2022-11-24",
      "completion_date": "2025-08-15",
      "has_results": true,
      "last_update_posted_date": "2026-08-12",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05290064"
    },
    {
      "nct_id": "NCT05545306",
      "title": "The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Normal Physiology",
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "fasting",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "-50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "+150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "+200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "-25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "+150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 120,
      "start_date": "2023-06-06",
      "completion_date": "2027-02-02",
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05545306"
    },
    {
      "nct_id": "NCT00108524",
      "title": "A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes Mellitus",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Low carbohydrate ketogenic diet",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Orlistat",
          "type": "DRUG"
        },
        {
          "name": "Low-fat diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "18 Years to 69 Years"
      },
      "enrollment_count": 146,
      "start_date": "2004-07",
      "completion_date": "2007-12",
      "has_results": true,
      "last_update_posted_date": "2014-04-17",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00108524"
    },
    {
      "nct_id": "NCT03946774",
      "title": "Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dietary Protein"
      ],
      "interventions": [
        {
          "name": "Dietary protein shake",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2019-10-01",
      "completion_date": "2023-05-04",
      "has_results": false,
      "last_update_posted_date": "2024-10-26",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03946774"
    },
    {
      "nct_id": "NCT00581269",
      "title": "Dietary Intervention and Exercise Training (DIET) in Moderate to Severe Chronic Kidney Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Kidney Disease"
      ],
      "interventions": [
        {
          "name": "low-impact aerobic exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "low-calorie (low-fat) diet",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 3,
      "start_date": "2007-12",
      "completion_date": "2009-04",
      "has_results": false,
      "last_update_posted_date": "2010-11-03",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00581269"
    },
    {
      "nct_id": "NCT00330629",
      "title": "Preference and Vegetarian Diet in Weight Loss Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Overweight"
      ],
      "interventions": [
        {
          "name": "Standard Behavioral Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "SBT+LOV",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 200,
      "start_date": "2002-01",
      "completion_date": "2005-09",
      "has_results": false,
      "last_update_posted_date": "2016-07-04",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00330629"
    },
    {
      "nct_id": "NCT04138303",
      "title": "Exercise and Nutrition on Obese Microbiome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Overweight and Obesity"
      ],
      "interventions": [
        {
          "name": "Exercise Protocol",
          "type": "OTHER"
        },
        {
          "name": "Calorie-Restrictive Low Carbohydrate Diet (CR-LC)",
          "type": "OTHER"
        },
        {
          "name": "Ancestral Diet (AD)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 31,
      "start_date": "2019-10-21",
      "completion_date": "2019-12-21",
      "has_results": false,
      "last_update_posted_date": "2020-01-07",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04138303"
    },
    {
      "nct_id": "NCT03878108",
      "title": "Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy",
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "LCHF diet",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "LFHC diet",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 21,
      "start_date": "2019-04-15",
      "completion_date": "2020-09-01",
      "has_results": true,
      "last_update_posted_date": "2021-06-03",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03878108"
    },
    {
      "nct_id": "NCT03650088",
      "title": "Adaptation of a Digital Weight Loss Intervention Promoting Self-regulation for Use in Type 2 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes Mellitus, Type 2",
        "Overweight and Obesity"
      ],
      "interventions": [
        {
          "name": "Behavioral weight loss with digital tools",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 18,
      "start_date": "2019-10-20",
      "completion_date": "2021-02-26",
      "has_results": true,
      "last_update_posted_date": "2023-01-13",
      "last_synced_at": "2026-10-07T13:34:28.954Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03650088"
    }
  ]
}