{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=menthol",
    "query": {
      "intervention": "menthol"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 159,
    "total_pages": 16,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=menthol&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-02T07:46:35.664Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04521647",
      "title": "Effects of Menthol in E-cigarettes on Smoking Behaviors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 14,
      "start_date": "2022-05-10",
      "completion_date": "2023-07-25",
      "has_results": true,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04521647"
    },
    {
      "nct_id": "NCT05307822",
      "title": "CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Smoking Behaviors",
        "Tobacco Use",
        "Tobacco Smoking"
      ],
      "interventions": [
        {
          "name": "Non-combusted cigarette variant 42001401",
          "type": "OTHER"
        },
        {
          "name": "Non-combusted cigarette variant 42001399",
          "type": "OTHER"
        },
        {
          "name": "Non-combusted cigarette variant 40007386",
          "type": "OTHER"
        },
        {
          "name": "Non-combusted cigarette variant 42001402",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "RAI Services Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 194,
      "start_date": "2022-04-21",
      "completion_date": "2022-11-11",
      "has_results": false,
      "last_update_posted_date": "2023-03-27",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 7,
      "location_summary": "Sandy Springs, Georgia • Lexington, Kentucky • Charlotte, North Carolina + 4 more",
      "locations": [
        {
          "city": "Sandy Springs",
          "state": "Georgia"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "High Point",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05307822"
    },
    {
      "nct_id": "NCT06910202",
      "title": "Effects of Cigarette and E-cigarette Flavors on Substitutability in the ETM",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking Behavior"
      ],
      "interventions": [
        {
          "name": "Manipulation of nicotine/tobacco product price and availability",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 25,
      "start_date": "2021-07-08",
      "completion_date": "2022-05-25",
      "has_results": true,
      "last_update_posted_date": "2025-12-09",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 1,
      "location_summary": "Roanoke, Virginia",
      "locations": [
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06910202"
    },
    {
      "nct_id": "NCT05129657",
      "title": "CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Tobacco Use",
        "Tobacco Smoking"
      ],
      "interventions": [
        {
          "name": "Product A",
          "type": "OTHER"
        },
        {
          "name": "Product B",
          "type": "OTHER"
        },
        {
          "name": "Product C",
          "type": "OTHER"
        },
        {
          "name": "Product D",
          "type": "OTHER"
        },
        {
          "name": "Product N",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "RAI Services Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "21 Years to 60 Years"
      },
      "enrollment_count": 40,
      "start_date": "2021-11-02",
      "completion_date": "2022-06-24",
      "has_results": false,
      "last_update_posted_date": "2024-04-30",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 2,
      "location_summary": "Raleigh, North Carolina • San Antonio, Texas",
      "locations": [
        {
          "city": "Raleigh",
          "state": "North Carolina"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05129657"
    },
    {
      "nct_id": "NCT05949034",
      "title": "Effects of E-Cigarettes in Menthol Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-cigarette Use",
        "Smoking Behaviors"
      ],
      "interventions": [
        {
          "name": "JUUL E-Cigarette Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 19,
      "start_date": "2019-07-01",
      "completion_date": "2020-11-14",
      "has_results": false,
      "last_update_posted_date": "2023-07-20",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05949034"
    },
    {
      "nct_id": "NCT05932745",
      "title": "Effects of Novel E-cigarette Constituents on Adults TCORS 3.0",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "E-liquid coolant (No WS-3) for non-menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for non-menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 66,
      "start_date": "2025-06-20",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05932745"
    },
    {
      "nct_id": "NCT06179290",
      "title": "Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Ploom HTP Menthol HTS; MX3 (681)",
          "type": "OTHER"
        },
        {
          "name": "Ploom HTP Tobacco HTS; R8 (120)",
          "type": "OTHER"
        },
        {
          "name": "Smoking Abstinence (menthol)",
          "type": "OTHER"
        },
        {
          "name": "Smoking Abstinence (non-menthol)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Altria Client Services LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 921,
      "start_date": "2023-10-02",
      "completion_date": "2025-03-24",
      "has_results": true,
      "last_update_posted_date": "2026-05-27",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 8,
      "location_summary": "Bentonville, Arkansas • Rogers, Arkansas • Overland Park, Kansas + 5 more",
      "locations": [
        {
          "city": "Bentonville",
          "state": "Arkansas"
        },
        {
          "city": "Rogers",
          "state": "Arkansas"
        },
        {
          "city": "Overland Park",
          "state": "Kansas"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06179290"
    },
    {
      "nct_id": "NCT04188197",
      "title": "Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation",
        "Harm Reduction",
        "E-Cig Use",
        "Cigarette Smoking",
        "Tobacco Dependence",
        "Tobacco Use Cessation"
      ],
      "interventions": [
        {
          "name": "JUUL",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 50,
      "start_date": "2019-08-26",
      "completion_date": "2021-06-22",
      "has_results": true,
      "last_update_posted_date": "2025-04-20",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 2,
      "location_summary": "Charlotte, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04188197"
    },
    {
      "nct_id": "NCT01721473",
      "title": "Brain Nicotine Receptor Density in Veteran Smokers",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Positron Emission Tomography"
      ],
      "interventions": [
        {
          "name": "positron emission tomography scan",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 184,
      "start_date": "2012-01-01",
      "completion_date": "2016-06-30",
      "has_results": true,
      "last_update_posted_date": "2019-10-07",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 2,
      "location_summary": "San Diego, California • West Los Angeles, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "West Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01721473"
    },
    {
      "nct_id": "NCT01329263",
      "title": "Smoking Topography and Harm Exposure in Menthol Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking Toxicity"
      ],
      "interventions": [
        {
          "name": "Menthol to non-menthol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 87,
      "start_date": "2010-09",
      "completion_date": "2011-09",
      "has_results": true,
      "last_update_posted_date": "2015-01-06",
      "last_synced_at": "2026-09-02T07:46:35.664Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01329263"
    }
  ]
}