{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=methylphenidate+%28MPH%29&page=2",
    "query": {
      "intervention": "methylphenidate (MPH)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 273,
    "total_pages": 28,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=methylphenidate+%28MPH%29&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=methylphenidate+%28MPH%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-02T06:50:10.678Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03190954",
      "title": "Brain Dopaminergic Signaling in Opioid Use Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Normal Physiology",
        "Opioid Use Disorders"
      ],
      "interventions": [
        {
          "name": "[11C]raclopride plus placebo",
          "type": "DRUG"
        },
        {
          "name": "[11C]raclopride plus drug",
          "type": "DRUG"
        },
        {
          "name": "[11C]NNC-112",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Alcohol Abuse and Alcoholism (NIAAA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 153,
      "start_date": "2017-08-17",
      "completion_date": "2025-10-27",
      "has_results": false,
      "last_update_posted_date": "2026-09-08",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03190954"
    },
    {
      "nct_id": "NCT00799409",
      "title": "Lab School Day Study for CONCERTA of Older Children With ADHD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder"
      ],
      "interventions": [
        {
          "name": "Placebo/ CONCERTA (methylphenidate HCl)",
          "type": "DRUG"
        },
        {
          "name": "CONCERTA (methylphenidate HCl) / Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ortho-McNeil Janssen Scientific Affairs, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "9 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "9 Years to 12 Years"
      },
      "enrollment_count": 78,
      "start_date": "2008-12",
      "completion_date": "2009-06",
      "has_results": true,
      "last_update_posted_date": "2014-05-09",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 2,
      "location_summary": "Irvine, California • Houston, Texas",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00799409"
    },
    {
      "nct_id": "NCT03420339",
      "title": "Stimulant Effects on Disruptive Behavior",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder",
        "Problem Behavior"
      ],
      "interventions": [
        {
          "name": "Stimulant",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Matthew J O'Brien, PhD, BCBA-D",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "48 Months",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "48 Months to 12 Years"
      },
      "enrollment_count": 10,
      "start_date": "2018-10-01",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-03-17",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03420339"
    },
    {
      "nct_id": "NCT01673594",
      "title": "Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "ADHD",
        "Stimulant-Induced Euphoria"
      ],
      "interventions": [
        {
          "name": "SODAS MPH",
          "type": "DRUG"
        },
        {
          "name": "Naltrexone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 37,
      "start_date": "2012-09",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2016-11-30",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01673594"
    },
    {
      "nct_id": "NCT03525873",
      "title": "A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 Immunotherapy",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Advanced Malignant Neoplasm",
        "Metastatic Malignant Neoplasm",
        "Recurrent Malignant Neoplasm"
      ],
      "interventions": [
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        },
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Physical Activity",
          "type": "OTHER"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "OTHER"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 212,
      "start_date": "2018-08-02",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-10-06",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03525873"
    },
    {
      "nct_id": "NCT05924594",
      "title": "Phase 3 Efficacy and Safety Laboratory Classroom Study in Pediatrics (6-12) With ADHD Using CTx-1301",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "ADHD",
        "ADHD - Combined Type",
        "Attention Deficit Hyper Activity",
        "Attention Deficit Hyperactivity Disorder",
        "Attention Deficit Disorder With Hyperactivity",
        "Attention Deficit Hyperactivity Disorder Combined",
        "Attention-deficit Hyperactivity"
      ],
      "interventions": [
        {
          "name": "CTx-1301 - Dexmethylphenidate 6.25mg",
          "type": "DRUG"
        },
        {
          "name": "CTx-1301 - Dexmethylphenidate 12.5mg",
          "type": "DRUG"
        },
        {
          "name": "CTx-1301 - Dexmethylphenidate 18.75mg",
          "type": "DRUG"
        },
        {
          "name": "CTx-1301 - Dexmethylphenidate 25.0mg",
          "type": "DRUG"
        },
        {
          "name": "CTx-1301 - Dexmethylphenidate 31.25mg",
          "type": "DRUG"
        },
        {
          "name": "CTx-1301 - Dexmethylphenidate 37.5mg",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cingulate Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "6 Years to 12 Years"
      },
      "enrollment_count": 45,
      "start_date": "2023-07-31",
      "completion_date": "2027-02",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 3,
      "location_summary": "Maitland, Florida • Las Vegas, Nevada • North Charleston, South Carolina",
      "locations": [
        {
          "city": "Maitland",
          "state": "Florida"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "North Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05924594"
    },
    {
      "nct_id": "NCT01966276",
      "title": "The Synergy Trial: Methylphenidate Plus a CFS-Specific Nutrient Formula as a Treatment for Chronic Fatigue Syndrome",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Fatigue Syndrome (CFS)",
        "Myalgic Encephalomyelitis (ME)"
      ],
      "interventions": [
        {
          "name": "Methyl-P plus Nutrient Formula",
          "type": "DRUG"
        },
        {
          "name": "Methyl-P plus Nutrient matched placebos",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "K-PAX Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 134,
      "start_date": "2013-11",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2014-09-25",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 4,
      "location_summary": "Stanford, California • Fort Lauderdale, Florida • New York, New York + 1 more",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01966276"
    },
    {
      "nct_id": "NCT04449250",
      "title": "Fed-Fast Crossover Study to Assess the Effect of Food With CTx-1301 in Healthy Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy Volunteers in Fed and Fasted State"
      ],
      "interventions": [
        {
          "name": "Dexmethylphenidate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cingulate Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 27,
      "start_date": "2022-09-14",
      "completion_date": "2022-10-14",
      "has_results": false,
      "last_update_posted_date": "2022-10-20",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04449250"
    },
    {
      "nct_id": "NCT01993108",
      "title": "Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS))",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy",
        "Attention Deficit Hyperactivity Disorder"
      ],
      "interventions": [
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Naltrexone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 23,
      "start_date": "2013-10",
      "completion_date": "2017-02",
      "has_results": true,
      "last_update_posted_date": "2018-06-18",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01993108"
    },
    {
      "nct_id": "NCT01290276",
      "title": "Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Ond-PR1",
          "type": "DRUG"
        },
        {
          "name": "Ond-PR1 + MPh-IR",
          "type": "DRUG"
        },
        {
          "name": "Ond-PR2",
          "type": "DRUG"
        },
        {
          "name": "Ond-PR2 +_ MPh-IR",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tong Lee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 6,
      "start_date": "2010-12",
      "completion_date": "2012-08",
      "has_results": false,
      "last_update_posted_date": "2014-08-01",
      "last_synced_at": "2026-11-02T06:50:10.678Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01290276"
    }
  ]
}