{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=methylphenidate+hydrochloride&page=2",
    "query": {
      "intervention": "methylphenidate hydrochloride",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=methylphenidate+hydrochloride&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T10:36:16.347Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00264797",
      "title": "Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "ADHD",
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "Methylphenidate (OROS-MPH)",
          "type": "DRUG"
        },
        {
          "name": "Methylphenidate (OROS-MPH) - Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "13 Years to 18 Years"
      },
      "enrollment_count": 303,
      "start_date": "2006-02",
      "completion_date": "2008-10",
      "has_results": true,
      "last_update_posted_date": "2013-06-07",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 12,
      "location_summary": "Denver, Colorado • Jacksonville, Florida • St. Petersburg, Florida + 9 more",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "St. Petersburg",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Fall River",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00264797"
    },
    {
      "nct_id": "NCT00015067",
      "title": "Cocaine-Methylphendidate Interaction Study - 4",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cocaine-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 8,
      "start_date": "1997-12",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00015067"
    },
    {
      "nct_id": "NCT06580041",
      "title": "Precision Care for Major Depressive Disorder",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Depression",
        "Depressive Disorder, Major"
      ],
      "interventions": [
        {
          "name": "Pramipexole",
          "type": "DRUG"
        },
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Phenelzine",
          "type": "DRUG"
        },
        {
          "name": "Mindfulness-based Stress Sensitivity Therapy (MBSST)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Complicated Grief Treatment (CGT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Care as usual (CAU) plan",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2024-11-12",
      "completion_date": "2029-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-05",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06580041"
    },
    {
      "nct_id": "NCT07650643",
      "title": "EEG Biomarkers for ADHD Stimulant Treatment",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "ADHD"
      ],
      "interventions": [
        {
          "name": "methylphenidate HCl",
          "type": "DRUG"
        },
        {
          "name": "Mixed amphetamine salts extended release",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "11 Years",
        "sex": "ALL",
        "summary": "7 Years to 11 Years"
      },
      "enrollment_count": 220,
      "start_date": "2026-09-15",
      "completion_date": "2031-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "Brookline, Massachusetts",
      "locations": [
        {
          "city": "Brookline",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07650643"
    },
    {
      "nct_id": "NCT01100658",
      "title": "Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ALL, Childhood",
        "Leukemia, Lymphoblastic",
        "Leukemia, Lymphoblastic, Acute",
        "Leukemia, Lymphoblastic, Acute, L1",
        "Leukemia, Lymphoblastic, Acute, L2",
        "Leukemia, Lymphoblastic, Acute, Philadelphia-Positive",
        "Leukemia, Lymphocytic, Acute",
        "Leukemia, Lymphocytic, Acute, L1",
        "Leukemia, Lymphocytic, Acute, L2",
        "Lymphoblastic Leukemia",
        "Lymphoblastic Leukemia, Acute",
        "Lymphoblastic Leukemia, Acute, Childhood",
        "Lymphoblastic Leukemia, Acute, L1",
        "Lymphoblastic Leukemia, Acute, L2",
        "Lymphoblastic Lymphoma",
        "Lymphocytic Leukemia, Acute",
        "Lymphocytic Leukemia, L1",
        "Lymphocytic Leukemia, L2",
        "Brain Tumors",
        "Cancer of the Brain",
        "Cancer of Brain",
        "Malignant Primary Brain Tumors",
        "Brain Neoplasms, Malignant"
      ],
      "interventions": [
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "8 Years to 17 Years"
      },
      "enrollment_count": 1,
      "start_date": "2010-05",
      "completion_date": "2010-11",
      "has_results": true,
      "last_update_posted_date": "2015-03-27",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01100658"
    },
    {
      "nct_id": "NCT00670293",
      "title": "Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Eating Disorders"
      ],
      "interventions": [
        {
          "name": "Positron Emission Tomography (PET) using [11C]raclopride",
          "type": "RADIATION"
        },
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Magnetic Resonance Imaging (MRI) scan",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "RADIATION",
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 50,
      "start_date": "2008-07",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2016-04-07",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00670293"
    },
    {
      "nct_id": "NCT02683265",
      "title": "A Flexible-Dose Titration Study of Aptensio XR in Children Ages 4 to Under 6 Years Diagnosed With ADHD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit Disorder With Hyperactivity"
      ],
      "interventions": [
        {
          "name": "Aptensio XR",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rhodes Pharmaceuticals, L.P.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "6 Years",
        "sex": "ALL",
        "summary": "4 Years to 6 Years"
      },
      "enrollment_count": 158,
      "start_date": "2016-04-25",
      "completion_date": "2018-03-27",
      "has_results": true,
      "last_update_posted_date": "2023-02-21",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 2,
      "location_summary": "Las Vegas, Nevada • Durham, North Carolina",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02683265"
    },
    {
      "nct_id": "NCT01678209",
      "title": "Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder",
        "ADHD"
      ],
      "interventions": [
        {
          "name": "fMRI scans",
          "type": "OTHER"
        },
        {
          "name": "Atomoxetine arm",
          "type": "DRUG"
        },
        {
          "name": "Methylphenidate arm",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 127,
      "start_date": "2012-10",
      "completion_date": "2018-04-30",
      "has_results": true,
      "last_update_posted_date": "2020-07-24",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01678209"
    },
    {
      "nct_id": "NCT00863499",
      "title": "International Study to Predict Optimised Treatment in Attention Deficit/Hyperactivity Disorder",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit/Hyperactivity Disorder"
      ],
      "interventions": [
        {
          "name": "Short Acting Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Long Acting Methylphenidate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "BRC Operations Pty. Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "6 Years to 17 Years"
      },
      "enrollment_count": 1344,
      "start_date": "2009-10",
      "completion_date": "2019-12",
      "has_results": false,
      "last_update_posted_date": "2018-07-11",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 5,
      "location_summary": "Colton, California • Tarzana, California • Englewood Cliffs, New Jersey + 2 more",
      "locations": [
        {
          "city": "Colton",
          "state": "California"
        },
        {
          "city": "Tarzana",
          "state": "California"
        },
        {
          "city": "Englewood Cliffs",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Asheville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00863499"
    },
    {
      "nct_id": "NCT01853280",
      "title": "L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder"
      ],
      "interventions": [
        {
          "name": "L-methylfolate",
          "type": "DRUG"
        },
        {
          "name": "OROS-Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 47,
      "start_date": "2014-05",
      "completion_date": "2017-09",
      "has_results": true,
      "last_update_posted_date": "2017-11-14",
      "last_synced_at": "2026-09-29T10:36:16.347Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01853280"
    }
  ]
}