{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=naltrexone+and+bupropion+SR", "query": { "intervention": "naltrexone and bupropion SR" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=naltrexone+and+bupropion+SR&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T10:20:19.991Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00474630", "title": "A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity", "Overweight", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Naltrexone SR 32 mg/bupropion SR 360 mg/ day", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ancillary therapy", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 505, "start_date": "2007-05", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2014-11-21", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 53, "location_summary": "Fairhope, Alabama • Peoria, Arizona • Phoenix, Arizona + 46 more", "locations": [ { "city": "Fairhope", "state": "Alabama" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00474630" }, { "nct_id": "NCT02259179", "title": "Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Reference naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets)", "type": "DRUG" }, { "name": "Test naltrexone 8 mg SR/bupropion 90 mg SR combination trilayer tablets (2 tablets)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 80, "start_date": "2014-09", "completion_date": "2014-12", "has_results": false, "last_update_posted_date": "2014-12-11", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02259179" }, { "nct_id": "NCT00129246", "title": "Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Smoking", "Nicotine Dependence" ], "interventions": [ { "name": "Naltrexone", "type": "DRUG" }, { "name": "Bupropion", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2004-12", "completion_date": "2005-12", "has_results": true, "last_update_posted_date": "2020-12-03", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00129246" }, { "nct_id": "NCT00567255", "title": "A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity", "Overweight" ], "interventions": [ { "name": "Naltrexone SR 32 mg/bupropion SR 360 mg/day", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ancillary therapy", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1496, "start_date": "2007-12", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2014-11-21", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 36, "location_summary": "Phoenix, Arizona • Hot Springs, Arkansas • Carmichael, California + 31 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Carmichael", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00567255" }, { "nct_id": "NCT00624858", "title": "A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression" ], "interventions": [ { "name": "naltrexone SR 32 mg/ bupropion SR 360 mg daily", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 25, "start_date": "2008-01", "completion_date": "2009-07", "has_results": false, "last_update_posted_date": "2012-10-30", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 1, "location_summary": "Mason, Ohio", "locations": [ { "city": "Mason", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00624858" }, { "nct_id": "NCT00364871", "title": "Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated Obesity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "naltrexone and bupropion SR", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 410, "start_date": "2005-04", "completion_date": "2007-03", "has_results": false, "last_update_posted_date": "2008-04-22", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 7, "location_summary": "San Diego, California • Augusta, Georgia • Lexington, Kentucky + 4 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Augusta", "state": "Georgia" }, { "city": "Lexington", "state": "Kentucky" }, { "city": "Baton Rouge", "state": "Louisiana" }, { "city": "Charlotte", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00364871" }, { "nct_id": "NCT03047005", "title": "Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Binge-Eating Disorder", "Obesity" ], "interventions": [ { "name": "NB medication (Naltrexone Bupropion combination)", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 68, "start_date": "2017-08-28", "completion_date": "2022-12-16", "has_results": true, "last_update_posted_date": "2024-02-02", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03047005" }, { "nct_id": "NCT00532779", "title": "A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity", "Overweight" ], "interventions": [ { "name": "Naltrexone SR 16 mg/Bupropion SR 360 mg /day", "type": "DRUG" }, { "name": "Naltrexone SR 32 mg/Bupropion SR 360 mg /day", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ancillary therapy", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1742, "start_date": "2007-10", "completion_date": "2009-05", "has_results": true, "last_update_posted_date": "2014-11-21", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 34, "location_summary": "Birmingham, Alabama • Fairhope, Alabama • Chandler, Arizona + 28 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00532779" }, { "nct_id": "NCT03045341", "title": "Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Binge-eating Disorder", "Obesity" ], "interventions": [ { "name": "NB medication (Naltrexone Bupropion combination)", "type": "DRUG" }, { "name": "Behavioral Weight Loss (BWL) counseling", "type": "BEHAVIORAL" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "BEHAVIORAL", "OTHER" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 136, "start_date": "2017-02-27", "completion_date": "2022-12-16", "has_results": true, "last_update_posted_date": "2023-03-08", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03045341" }, { "nct_id": "NCT00456521", "title": "A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification Program", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity", "Overweight" ], "interventions": [ { "name": "Naltrexone SR 32 mg/ bupropion SR 360 mg/ day", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Intensive group lifestyle modification counseling", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Orexigen Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 793, "start_date": "2007-03", "completion_date": "2008-12", "has_results": true, "last_update_posted_date": "2014-12-17", "last_synced_at": "2026-09-30T10:20:19.991Z", "location_count": 9, "location_summary": "La Jolla, California • Denver, Colorado • Gainesville, Florida + 5 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Gainesville", "state": "Florida" }, { "city": "St Louis", "state": "Missouri" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00456521" } ] }