{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=naproxen+250+mg", "query": { "intervention": "naproxen 250 mg" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 18, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=naproxen+250+mg&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-21T21:54:55.151Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02128490", "title": "Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout and Moderate Renal Impairment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Gout", "Moderate Renal Impairment" ], "interventions": [ { "name": "Febuxostat IR", "type": "DRUG" }, { "name": "Febuxostat XR", "type": "DRUG" }, { "name": "Febuxostat placebo", "type": "DRUG" }, { "name": "Colchicine", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Lansoprazole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 189, "start_date": "2014-05", "completion_date": "2015-10", "has_results": true, "last_update_posted_date": "2016-11-03", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 89, "location_summary": "Birmingham, Alabama • Muscle Shoals, Alabama • Phoenix, Arizona + 75 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02128490" }, { "nct_id": "NCT01165307", "title": "Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Menorrhagia" ], "interventions": [ { "name": "Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills", "type": "DRUG" }, { "name": "Naproxen sodium pills", "type": "DRUG" }, { "name": "NovaSure® Radiofrequency Endometrial Ablation", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Abimbola Famuyide", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "55 Years", "sex": "FEMALE", "summary": "30 Years to 55 Years · Female only" }, "enrollment_count": 77, "start_date": "2009-08", "completion_date": "2015-10", "has_results": true, "last_update_posted_date": "2017-01-20", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT01165307" }, { "nct_id": "NCT00662896", "title": "To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Osteoarthritis", "Hypertension" ], "interventions": [ { "name": "naproxcinod 375 mg bid", "type": "DRUG" }, { "name": "naproxcinod 750 mg bid", "type": "DRUG" }, { "name": "naproxen 250 mg bid", "type": "DRUG" }, { "name": "naproxen 500 mg bid", "type": "DRUG" }, { "name": "ibuprofen 600 mg tid", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "NicOx", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 300, "start_date": "2008-03", "completion_date": "2008-12", "has_results": false, "last_update_posted_date": "2011-06-17", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 57, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Sierra Vista, Arizona + 54 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Sierra Vista", "state": "Arizona" }, { "city": "Carmichael", "state": "California" }, { "city": "Fair Oaks", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00662896" }, { "nct_id": "NCT01557816", "title": "Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Osteoarthritis, Knee" ], "interventions": [ { "name": "Naproxen", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Analgesic Solutions", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 70, "start_date": "2011-12", "completion_date": "2012-06", "has_results": false, "last_update_posted_date": "2012-03-22", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 1, "location_summary": "Natick, Massachusetts", "locations": [ { "city": "Natick", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01557816" }, { "nct_id": "NCT00780325", "title": "Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "CG100649 (2 mg)", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Placebo capsules", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Acetazolamide", "type": "DRUG" }, { "name": "CG100649 (8 mg)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 26, "start_date": "2008-10", "completion_date": "2013-07", "has_results": false, "last_update_posted_date": "2014-02-06", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00780325" }, { "nct_id": "NCT07750639", "title": "Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Opioid Abuse (Disorder)", "Opioid Analgesia", "Opioid Analgesic Adverse Reaction", "Opioid Consumption" ], "interventions": [ { "name": "Naproxen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "oxycodone", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AdventHealth", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 260, "start_date": "2024-08-01", "completion_date": "2026-12-30", "has_results": false, "last_update_posted_date": "2026-09-17", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 1, "location_summary": "Orlando, Florida", "locations": [ { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07750639" }, { "nct_id": "NCT05722002", "title": "Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Surgery", "Pain, Postoperative" ], "interventions": [ { "name": "NSAID", "type": "DRUG" }, { "name": "Opioid", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 900, "start_date": "2023-02-06", "completion_date": "2027-08-31", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 6, "location_summary": "Ann Arbor, Michigan • Detroit, Michigan • St Louis, Missouri + 3 more", "locations": [ { "city": "Ann Arbor", "state": "Michigan" }, { "city": "Detroit", "state": "Michigan" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Camden", "state": "New Jersey" }, { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05722002" }, { "nct_id": "NCT01544114", "title": "A Safety Study of VIMOVO in Adolescents With Juvenile Idiopathic Arthritis (JIA)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Juvenile Idiopathic Arthritis (JIA)" ], "interventions": [ { "name": "VIMOVO 250/20", "type": "DRUG" }, { "name": "VIMOVO 375/20", "type": "DRUG" }, { "name": "VIMOVO 500/20", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Amgen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "16 Years", "sex": "ALL", "summary": "12 Years to 16 Years" }, "enrollment_count": 46, "start_date": "2012-04", "completion_date": "2015-02", "has_results": true, "last_update_posted_date": "2024-12-17", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 17, "location_summary": "Little Rock, Arkansas • San Francisco, California • Aurora, Colorado + 14 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "West Palm Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01544114" }, { "nct_id": "NCT01884272", "title": "NSAID Drug Interaction Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Gout" ], "interventions": [ { "name": "lesinurad 400 mg", "type": "DRUG" }, { "name": "naproxen 250 mg", "type": "DRUG" }, { "name": "indomethacin 25 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ardea Biosciences, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "MALE", "summary": "18 Years to 55 Years · Male only" }, "enrollment_count": 24, "start_date": "2013-06", "completion_date": "2013-10", "has_results": false, "last_update_posted_date": "2013-11-08", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 1, "location_summary": "Kalamazoo, Michigan", "locations": [ { "city": "Kalamazoo", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01884272" }, { "nct_id": "NCT00662610", "title": "A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Osteoarthritis", "Hypertension" ], "interventions": [ { "name": "naproxcinod 375 mg -750 mg -1125 mg bid", "type": "DRUG" }, { "name": "naproxen 250 mg - 500mg -750 mg bid", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "NicOx", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 120, "start_date": "2008-03", "completion_date": "2008-11", "has_results": false, "last_update_posted_date": "2011-06-17", "last_synced_at": "2026-09-21T21:54:55.151Z", "location_count": 29, "location_summary": "Mobile, Alabama • Tempe, Arizona • Tucson, Arizona + 26 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Buena Park", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00662610" } ] }