{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=nicotine+replacement+therapy+and+bupropion",
    "query": {
      "intervention": "nicotine replacement therapy and bupropion"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 53,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=nicotine+replacement+therapy+and+bupropion&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T07:59:50.120Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01560507",
      "title": "Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Cigarette Smoking",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "varenicline (Chantix)",
          "type": "DRUG"
        },
        {
          "name": "bupropion (Zyban)",
          "type": "DRUG"
        },
        {
          "name": "nicotine patches",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 19,
      "start_date": "2012-05",
      "completion_date": "2013-07",
      "has_results": true,
      "last_update_posted_date": "2014-12-24",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 2,
      "location_summary": "Durham, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01560507"
    },
    {
      "nct_id": "NCT04135937",
      "title": "Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Human Immunodeficiency Virus",
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Cognitive Behavioral Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine Replacement Therapy",
          "type": "DRUG"
        },
        {
          "name": "Relapse Prevention Text Messaging",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2019-11-18",
      "completion_date": "2021-11-10",
      "has_results": true,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04135937"
    },
    {
      "nct_id": "NCT04798664",
      "title": "Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Removal of Financial Barriers",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Financial Incentives",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Health Application",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3228,
      "start_date": "2021-05-17",
      "completion_date": "2025-04-29",
      "has_results": true,
      "last_update_posted_date": "2026-02-25",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 5,
      "location_summary": "Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Danville",
          "state": "Pennsylvania"
        },
        {
          "city": "Lancaster",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04798664"
    },
    {
      "nct_id": "NCT01456936",
      "title": "Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "varenicline tartrate",
          "type": "DRUG"
        },
        {
          "name": "bupropion hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Replacement Therapy Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 8144,
      "start_date": "2011-11",
      "completion_date": "2015-01",
      "has_results": true,
      "last_update_posted_date": "2016-06-10",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 77,
      "location_summary": "Mobile, Alabama • Phoenix, Arizona • Encino, California + 61 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Escondido",
          "state": "California"
        },
        {
          "city": "Imperial",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01456936"
    },
    {
      "nct_id": "NCT01299896",
      "title": "Connect to Quit for Smoking",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Coordinated Care",
          "type": "OTHER"
        },
        {
          "name": "Usual Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 633,
      "start_date": "2011-03",
      "completion_date": "2015-02",
      "has_results": true,
      "last_update_posted_date": "2016-03-22",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01299896"
    },
    {
      "nct_id": "NCT01691105",
      "title": "Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use Cessation",
        "Smoking Cessation",
        "Smoking",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "AD + Integrated Tobacco Order Set",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1044,
      "start_date": "2013-08",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2021-09-05",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01691105"
    },
    {
      "nct_id": "NCT02873754",
      "title": "Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Cognitive Behavioral Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Transdermal nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Nicotine polacrilex",
          "type": "DRUG"
        },
        {
          "name": "Nicotine lozenge",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 11,
      "start_date": "2017-01",
      "completion_date": "2017-07",
      "has_results": true,
      "last_update_posted_date": "2018-07-13",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02873754"
    },
    {
      "nct_id": "NCT00087880",
      "title": "Maintaining Abstinence in Chronic Cigarette Smokers - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Bupropion and NRT",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 407,
      "start_date": "2002-12",
      "completion_date": "2009-09",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00087880"
    },
    {
      "nct_id": "NCT02420015",
      "title": "Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Schizophrenia",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "cognitive-behavioral smoking cessation counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stay Quit Coach",
          "type": "BEHAVIORAL"
        },
        {
          "name": "SMS text messaging",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 35,
      "start_date": "2017-03-27",
      "completion_date": "2019-01-24",
      "has_results": true,
      "last_update_posted_date": "2019-07-10",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02420015"
    },
    {
      "nct_id": "NCT02582008",
      "title": "Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Current Smoker",
        "Head and Neck Squamous Cell Carcinoma",
        "Hypopharyngeal Squamous Cell Carcinoma",
        "Laryngeal Squamous Cell Carcinoma",
        "Nasopharyngeal Carcinoma",
        "Oral Cavity Squamous Cell Carcinoma",
        "Oropharyngeal Squamous Cell Carcinoma"
      ],
      "interventions": [
        {
          "name": "Bupropion Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Replacement",
          "type": "DRUG"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "OTHER"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        },
        {
          "name": "Varenicline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 9,
      "start_date": "2016-01",
      "completion_date": "2019-09-06",
      "has_results": false,
      "last_update_posted_date": "2023-03-22",
      "last_synced_at": "2026-09-29T07:59:50.120Z",
      "location_count": 2,
      "location_summary": "Winston-Salem, North Carolina • Charleston, South Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02582008"
    }
  ]
}