{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=nicotine+replacement+therapy+and+bupropion&page=3", "query": { "intervention": "nicotine replacement therapy and bupropion", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 53, "total_pages": 6, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=nicotine+replacement+therapy+and+bupropion&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=nicotine+replacement+therapy+and+bupropion&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-07T12:54:43.268Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07835555", "title": "Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Tobacco Use Disorder/Cigarette Smoking", "HIV" ], "interventions": [ { "name": "nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion", "type": "DRUG" }, { "name": "Multi-target Contingency Management", "type": "BEHAVIORAL" }, { "name": "Teamlet booster", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 794, "start_date": "2027-09-30", "completion_date": "2031-09-30", "has_results": false, "last_update_posted_date": "2026-09-23", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 5, "location_summary": "Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more", "locations": [ { "city": "Bridgeport", "state": "Connecticut" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Jersey City", "state": "New Jersey" }, { "city": "Paterson", "state": "New Jersey" }, { "city": "Brooklyn", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07835555" }, { "nct_id": "NCT00436943", "title": "Smoking Cessation Program: A Quality Improvement Trial in a Resident-Based Outpatient Clinic", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Smoking" ], "interventions": [ { "name": "nicotine replacement therapy and bupropion", "type": "DRUG" }, { "name": "smoking cessation counseling and referrals", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Atlantic Health System", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 900, "start_date": "2007-01", "completion_date": "2008-01", "has_results": false, "last_update_posted_date": "2010-07-12", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 1, "location_summary": "Morristown, New Jersey", "locations": [ { "city": "Morristown", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00436943" }, { "nct_id": "NCT01303861", "title": "Concurrent Bupropion / Varenicline for Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Nicotine Dependence" ], "interventions": [ { "name": "Varenicline", "type": "DRUG" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "Nicotine patches", "type": "DRUG" }, { "name": "Nicotine Inhaler", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 702, "start_date": "2011-03", "completion_date": "2013-07", "has_results": true, "last_update_posted_date": "2014-08-06", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 4, "location_summary": "Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more", "locations": [ { "city": "Charlotte", "state": "North Carolina" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Raleigh", "state": "North Carolina" }, { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01303861" }, { "nct_id": "NCT01406223", "title": "Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Nicotine Dependence" ], "interventions": [ { "name": "Varenicline", "type": "DRUG" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "Nicotine patches", "type": "DRUG" }, { "name": "Placebo varenicline", "type": "OTHER" }, { "name": "Placebo bupropion", "type": "OTHER" }, { "name": "Placebo patch", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 282, "start_date": "2011-07", "completion_date": "2014-06", "has_results": true, "last_update_posted_date": "2017-11-14", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 2, "location_summary": "Durham, North Carolina • Raleigh, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" }, { "city": "Raleigh", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01406223" }, { "nct_id": "NCT01901848", "title": "CPT and Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Stress Disorders, Post-Traumatic", "Smoking" ], "interventions": [ { "name": "Cognitive Processing Therapy (CPT)", "type": "BEHAVIORAL" }, { "name": "Bupropion", "type": "DRUG" }, { "name": "nicotine replacement therapy (NRT)", "type": "DRUG" }, { "name": "Integrated Care for Smoking Cessation (ICSC)", "type": "BEHAVIORAL" }, { "name": "smokefreeVET", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 69, "start_date": "2013-12-11", "completion_date": "2017-07-30", "has_results": true, "last_update_posted_date": "2018-09-11", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01901848" }, { "nct_id": "NCT04604509", "title": "Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Cigarette Smoking-Related Carcinoma" ], "interventions": [ { "name": "Bupropion Hydrochloride Controlled-release", "type": "DRUG" }, { "name": "Nicotine Replacement", "type": "DRUG" }, { "name": "Questionnaire Administration", "type": "OTHER" }, { "name": "Tobacco Cessation Counseling", "type": "OTHER" }, { "name": "Varenicline", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2010, "start_date": "2020-08-04", "completion_date": "2028-12-31", "has_results": false, "last_update_posted_date": "2026-05-04", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04604509" }, { "nct_id": "NCT01560507", "title": "Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Cigarette Smoking", "Nicotine Dependence" ], "interventions": [ { "name": "varenicline (Chantix)", "type": "DRUG" }, { "name": "bupropion (Zyban)", "type": "DRUG" }, { "name": "nicotine patches", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 19, "start_date": "2012-05", "completion_date": "2013-07", "has_results": true, "last_update_posted_date": "2014-12-24", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 2, "location_summary": "Durham, North Carolina • Raleigh, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" }, { "city": "Raleigh", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01560507" }, { "nct_id": "NCT01574703", "title": "Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Smoking Cessation" ], "interventions": [ { "name": "placebo", "type": "DRUG" }, { "name": "varenicline tartrate", "type": "DRUG" }, { "name": "bupropion hydrochloride", "type": "DRUG" }, { "name": "Nicotine Replacement Therapy Patch", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 4595, "start_date": "2012-05", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2016-12-29", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 65, "location_summary": "Mobile, Alabama • Encino, California • Escondido, California + 54 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Encino", "state": "California" }, { "city": "Escondido", "state": "California" }, { "city": "Imperial", "state": "California" }, { "city": "La Habra", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01574703" }, { "nct_id": "NCT01990079", "title": "Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "PTSD", "Smoking" ], "interventions": [ { "name": "Bupropion", "type": "DRUG" }, { "name": "nicotine replacement therapy", "type": "DRUG" }, { "name": "Smoking cessation counseling", "type": "OTHER" }, { "name": "mobile contingency management", "type": "BEHAVIORAL" }, { "name": "Stay Quit Coach", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER", "BEHAVIORAL" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 15, "start_date": "2013-12", "completion_date": "2015-08", "has_results": false, "last_update_posted_date": "2026-05-18", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01990079" }, { "nct_id": "NCT04523948", "title": "Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Tobacco Use" ], "interventions": [ { "name": "Behavioral and pharmacological support to reduce combustible tobacco use.", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Rose Research Center, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 100, "start_date": "2020-01-30", "completion_date": "2023-07-31", "has_results": false, "last_update_posted_date": "2021-09-28", "last_synced_at": "2026-10-07T12:54:43.268Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04523948" } ] }