{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=oxygen+nitrogen",
    "query": {
      "intervention": "oxygen nitrogen"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 147,
    "total_pages": 15,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=oxygen+nitrogen&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T12:05:03.820Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06867068",
      "title": "Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Anesthesia",
        "Tooth Extraction"
      ],
      "interventions": [
        {
          "name": "Midazolam Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Fentanyl",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        },
        {
          "name": "Propofol injection",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Albert Einstein College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 73,
      "start_date": "2016-10-04",
      "completion_date": "2024-06-10",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06867068"
    },
    {
      "nct_id": "NCT00000263",
      "title": "Effects of Combined Alcohol and Nitrous Oxide Intake - 15",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "30% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.25 g/Kg ethanol",
          "type": "OTHER"
        },
        {
          "name": "0.5 g/KG ethanol",
          "type": "OTHER"
        },
        {
          "name": "0 g/Kg ethanol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 11,
      "start_date": "1997-01",
      "completion_date": "1998-10",
      "has_results": false,
      "last_update_posted_date": "2015-05-27",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000263"
    },
    {
      "nct_id": "NCT04388683",
      "title": "Inhaled Nitric Oxide for Preventing Progression in COVID-19",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID-19"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 10,
      "start_date": "2020-05-12",
      "completion_date": "2020-11-23",
      "has_results": true,
      "last_update_posted_date": "2022-04-19",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04388683"
    },
    {
      "nct_id": "NCT00023296",
      "title": "Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Sickle Cell Anemia",
        "Pulmonary Hypertension"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DRUG"
        },
        {
          "name": "INO Pulse - NO Delivery System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 59,
      "start_date": "2001-07-27",
      "completion_date": "2015-11-09",
      "has_results": false,
      "last_update_posted_date": "2019-12-17",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00023296"
    },
    {
      "nct_id": "NCT07420530",
      "title": "Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Exercise-Induced Vocal Cord Dysfunction",
        "Paradoxical Vocal Fold Motion",
        "Vocal Cord Dysfunction"
      ],
      "interventions": [
        {
          "name": "Carbon Dioxide",
          "type": "DRUG"
        },
        {
          "name": "Mechano-acoustic device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "18 Years to 26 Years"
      },
      "enrollment_count": 130,
      "start_date": "2026-08-12",
      "completion_date": "2032-01-20",
      "has_results": false,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Bloomington, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07420530"
    },
    {
      "nct_id": "NCT02391714",
      "title": "Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Contraception"
      ],
      "interventions": [
        {
          "name": "IUD insertion",
          "type": "PROCEDURE"
        },
        {
          "name": "Povidone-Iodine",
          "type": "DRUG"
        },
        {
          "name": "Chlorhexidine",
          "type": "DRUG"
        },
        {
          "name": "Oxygen",
          "type": "OTHER"
        },
        {
          "name": "Nitrous oxide",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "12 Years and older · Female only"
      },
      "enrollment_count": 80,
      "start_date": "2013-10",
      "completion_date": "2014-08",
      "has_results": true,
      "last_update_posted_date": "2016-02-03",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02391714"
    },
    {
      "nct_id": "NCT02133586",
      "title": "Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Depression"
      ],
      "interventions": [
        {
          "name": "Ozone",
          "type": "OTHER"
        },
        {
          "name": "Nitrogen dioxide",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Environmental Protection Agency (EPA)",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 54,
      "start_date": "2014-01",
      "completion_date": "2016-01",
      "has_results": false,
      "last_update_posted_date": "2020-08-17",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02133586"
    },
    {
      "nct_id": "NCT02755090",
      "title": "Nitrous Oxide Versus Intravenous Sedation for Anesthesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy Termination in Second Trimester"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        },
        {
          "name": "IV Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 39,
      "start_date": "2016-07",
      "completion_date": "2017-05",
      "has_results": true,
      "last_update_posted_date": "2017-09-15",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 2,
      "location_summary": "Denver, Colorado • Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02755090"
    },
    {
      "nct_id": "NCT03826693",
      "title": "Efficacy of Nitrous Oxide in OCD: Pilot Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Obsessive-Compulsive Disorder"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        },
        {
          "name": "Nitrogen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 45,
      "start_date": "2021-04-17",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2025-08-27",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03826693"
    },
    {
      "nct_id": "NCT04151927",
      "title": "Effects of Overnight Low Oxygen Exposure on Energy Balance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Resting Metabolic Rate",
        "Appetite",
        "Heart Rate Variability"
      ],
      "interventions": [
        {
          "name": "Normobaric Hypoxia",
          "type": "DEVICE"
        },
        {
          "name": "Normobaric Normoxia",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Florida State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "20 Years to 45 Years"
      },
      "enrollment_count": 20,
      "start_date": "2019-12-11",
      "completion_date": "2021-10-02",
      "has_results": false,
      "last_update_posted_date": "2021-11-29",
      "last_synced_at": "2026-09-03T12:05:03.820Z",
      "location_count": 1,
      "location_summary": "Tallahassee, Florida",
      "locations": [
        {
          "city": "Tallahassee",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04151927"
    }
  ]
}