{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=placebo+to+match+pioglitazone", "query": { "intervention": "placebo to match pioglitazone" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 35, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=placebo+to+match+pioglitazone&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-05T03:28:18.656Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01703260", "title": "Safety and Efficacy of Roflumilast and Pioglitazone in Treating Adults With Nonalcoholic SteatoHepatitis", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Nonalcoholic Steatohapatitis" ], "interventions": [ { "name": "Roflumilast", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 20, "start_date": "2013-06", "completion_date": "2014-09", "has_results": true, "last_update_posted_date": "2017-02-01", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 4, "location_summary": "Coronado, California • Annapolis, Maryland • Baltimore, Maryland", "locations": [ { "city": "Coronado", "state": "California" }, { "city": "Coronado", "state": "California" }, { "city": "Annapolis", "state": "Maryland" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01703260" }, { "nct_id": "NCT00395512", "title": "Efficacy of Alogliptin With Pioglitazone (Actos®) in Subjects With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Alogliptin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 655, "start_date": "2006-11", "completion_date": "2008-02", "has_results": true, "last_update_posted_date": "2013-03-27", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 83, "location_summary": "Columbiana, Alabama • Hueytown, Alabama • Huntsville, Alabama + 80 more", "locations": [ { "city": "Columbiana", "state": "Alabama" }, { "city": "Hueytown", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Northport", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00395512" }, { "nct_id": "NCT01280123", "title": "Pioglitazone in Early Parkinson's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Parkinson's Disease" ], "interventions": [ { "name": "Pioglitazone", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Rochester", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 210, "start_date": "2011-03", "completion_date": "2014-05", "has_results": true, "last_update_posted_date": "2015-10-14", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 38, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Fountain Valley, California + 32 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01280123" }, { "nct_id": "NCT02284906", "title": "AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mild Cognitive Impairment Due to Alzheimer's Disease" ], "interventions": [ { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 40, "start_date": "2015-02-12", "completion_date": "2018-05-08", "has_results": true, "last_update_posted_date": "2019-07-02", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 28, "location_summary": "Phoenix, Arizona • Sun City, Arizona • San Diego, California + 25 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Sun City", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Delray Beach", "state": "Florida" }, { "city": "Fort Myers", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02284906" }, { "nct_id": "NCT00722917", "title": "Efficacy and Safety of TAK-379 in Adult Subjects With Type 2 Diabetes Mellitus", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "TAK-379", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 323, "start_date": "2008-07", "completion_date": "2009-04", "has_results": false, "last_update_posted_date": "2016-06-22", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 8, "location_summary": "Artesia, California • Norwalk, California • Santa Ana, California + 5 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Norwalk", "state": "California" }, { "city": "Santa Ana", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Panama City", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00722917" }, { "nct_id": "NCT00286494", "title": "Study of Alogliptin Combined With Pioglitazone in Subjects With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Alogliptin and pioglitazone", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 493, "start_date": "2006-02", "completion_date": "2007-08", "has_results": true, "last_update_posted_date": "2012-02-03", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 64, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Anaheim, California + 61 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Artesia", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00286494" }, { "nct_id": "NCT01106690", "title": "The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Canagliflozin", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 344, "start_date": "2010-06", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2013-07-15", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 41, "location_summary": "Anniston, Alabama • Phoenix, Arizona • Tucson, Arizona + 38 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Burlingame", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01106690" }, { "nct_id": "NCT00631007", "title": "A Placebo Controlled Safety and Efficacy Study of INT131 Besylate in Type 2 Diabetes, With an Active Comparator", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "INT131 besylate", "type": "DRUG" }, { "name": "Pioglitazone HCl", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "InteKrin Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "30 Years to 75 Years" }, "enrollment_count": 367, "start_date": "2008-02", "completion_date": "2009-09", "has_results": true, "last_update_posted_date": "2010-09-13", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 59, "location_summary": "Carmichael, California • Los Angeles, California • San Diego, California + 48 more", "locations": [ { "city": "Carmichael", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Ana", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00631007" }, { "nct_id": "NCT06336798", "title": "Bioenergetic Effect of Pioglitazone in CLD-PH", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Pulmonary Hypertension", "Pulmonary Hypertension Due to Lung Diseases" ], "interventions": [ { "name": "Pioglitazone 30mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Labs", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DRUG", "DIAGNOSTIC_TEST" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2024-12-17", "completion_date": "2028-02", "has_results": false, "last_update_posted_date": "2026-07-22", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT06336798" }, { "nct_id": "NCT01931566", "title": "Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mild Cognitive Impairment Due to Alzheimer's Disease" ], "interventions": [ { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Pioglitazone placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "65 Years", "maximum_age": "83 Years", "sex": "ALL", "summary": "65 Years to 83 Years" }, "enrollment_count": 3494, "start_date": "2013-08-01", "completion_date": "2018-09-06", "has_results": true, "last_update_posted_date": "2019-09-16", "last_synced_at": "2026-10-05T03:28:18.656Z", "location_count": 34, "location_summary": "Phoenix, Arizona • Sun City, Arizona • Long Beach, California + 31 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Sun City", "state": "Arizona" }, { "city": "Long Beach", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01931566" } ] }