{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=quetiapine+extended-release", "query": { "intervention": "quetiapine extended-release" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 22, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=quetiapine+extended-release&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-24T13:08:18.065Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00868374", "title": "Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder", "Generalized Anxiety Disorder" ], "interventions": [ { "name": "Quetiapine XR", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Keming Gao", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 23, "start_date": "2008-06", "completion_date": "2011-10", "has_results": true, "last_update_posted_date": "2016-12-29", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00868374" }, { "nct_id": "NCT01810380", "title": "Brexpiprazole in Patients With Acute Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Brexpiprazole", "type": "DRUG" }, { "name": "Quetiapine extended release", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "H. Lundbeck A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 468, "start_date": "2013-03", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2017-03-16", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Escondido, California", "locations": [ { "city": "Escondido", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01810380" }, { "nct_id": "NCT01971203", "title": "Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the Treat", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder", "Generalized Anxiety Disorder" ], "interventions": [ { "name": "seroquel xr", "type": "DRUG" }, { "name": "CBT", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 62, "start_date": "2009-09", "completion_date": "2013-06", "has_results": true, "last_update_posted_date": "2018-02-15", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01971203" }, { "nct_id": "NCT00315900", "title": "Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Agitation", "Dementia" ], "interventions": [ { "name": "Depakote ER", "type": "DRUG" }, { "name": "Seroquel", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tuscaloosa Research & Education Advancement Corporation", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": null, "sex": "ALL", "summary": "55 Years and older" }, "enrollment_count": 20, "start_date": "2006-05-01", "completion_date": "2008-02-28", "has_results": false, "last_update_posted_date": "2017-04-27", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Tuscaloosa, Alabama", "locations": [ { "city": "Tuscaloosa", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT00315900" }, { "nct_id": "NCT00309699", "title": "A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder", "Mood Disorders" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Quetiapine", "type": "DRUG" }, { "name": "Paliperidone ER", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 493, "start_date": "2006-04", "completion_date": "2007-11", "has_results": false, "last_update_posted_date": "2014-06-20", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 22, "location_summary": "Cerritos, California • Garden Grove, California • Oceanside, California + 19 more", "locations": [ { "city": "Cerritos", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Oceanside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Bradenton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00309699" }, { "nct_id": "NCT06433635", "title": "Sequential Multiple Assignment Randomized Trial for Bipolar Depression", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar I Disorder", "Depression" ], "interventions": [ { "name": "Cariprazine", "type": "DRUG" }, { "name": "Aripiprazole/Escitalopram combination", "type": "DRUG" }, { "name": "Quetiapine", "type": "DRUG" }, { "name": "Lurasidone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 2726, "start_date": "2024-10-01", "completion_date": "2030-02-28", "has_results": false, "last_update_posted_date": "2025-12-16", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 17, "location_summary": "Birmingham, Alabama • Bloomington, Indiana • Baltimore, Maryland + 13 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Bloomington", "state": "Indiana" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Belmont", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06433635" }, { "nct_id": "NCT00606541", "title": "An Open Label, Double-blind Discontinuation Study of Quetiapine Extended Release(XR)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Social Anxiety Disorder" ], "interventions": [ { "name": "Quetiapine XR", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 55, "start_date": "2008-01", "completion_date": "2012-11", "has_results": false, "last_update_posted_date": "2014-08-01", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00606541" }, { "nct_id": "NCT04513912", "title": "A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Seltorexant", "type": "DRUG" }, { "name": "Matching placebo to Seltorexant", "type": "DRUG" }, { "name": "Quetiapine XR", "type": "DRUG" }, { "name": "Matching placebo to Quetiapine XR", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 757, "start_date": "2020-09-15", "completion_date": "2023-10-03", "has_results": false, "last_update_posted_date": "2025-08-13", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 75, "location_summary": "Birmingham, Alabama • Tucson, Arizona • Culver City, California + 62 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Culver City", "state": "California" }, { "city": "Encino", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04513912" }, { "nct_id": "NCT00702676", "title": "Quetiapine Fumarate Immediate Release (IR) Versus Extended Release (XR) Dose Escalation Comparison", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "Quetiapine Fumarate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 63, "start_date": "2008-07", "completion_date": "2008-08", "has_results": false, "last_update_posted_date": "2009-07-16", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00702676" }, { "nct_id": "NCT00631748", "title": "Quetiapine for the Reduction of Cocaine Use", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cocaine Dependence", "Cocaine Abuse", "Cocaine Addiction", "Drug Abuse", "Substance Abuse" ], "interventions": [ { "name": "quetiapine fumarate", "type": "DRUG" }, { "name": "Matched Placebo", "type": "DRUG" }, { "name": "Cognitive-behavioral Therapy", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Seattle Institute for Biomedical and Clinical Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2008-02", "completion_date": "2010-07", "has_results": true, "last_update_posted_date": "2014-03-31", "last_synced_at": "2026-09-24T13:08:18.065Z", "location_count": 1, "location_summary": "Tacoma, Washington", "locations": [ { "city": "Tacoma", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00631748" } ] }