{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=spontaneous+breathing+trial",
    "query": {
      "intervention": "spontaneous breathing trial"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 38,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=spontaneous+breathing+trial&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-23T13:36:27.973Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04654754",
      "title": "Aerosol Particle Concentrations Among Different Oxygen Devices for Spontaneous Breathing Patients With Tracheostomy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Transmission, Patient-Professional"
      ],
      "interventions": [
        {
          "name": "high-flow high humidity oxygen device with tracheostomy adapter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Jie Li",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 12,
      "start_date": "2020-12-23",
      "completion_date": "2021-07-16",
      "has_results": true,
      "last_update_posted_date": "2022-12-21",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04654754"
    },
    {
      "nct_id": "NCT01471431",
      "title": "Extubation Readiness Study in Very Low Birthweight Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "spontaneous breathing trial",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "48 Hours",
        "maximum_age": "14 Weeks",
        "sex": "ALL",
        "summary": "48 Hours to 14 Weeks"
      },
      "enrollment_count": 81,
      "start_date": "2011-08",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-06-07",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 2,
      "location_summary": "Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Phialdelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01471431"
    },
    {
      "nct_id": "NCT05008328",
      "title": "Feasibility of Music Therapy for Spontaneous Breathing Trials",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spontaneous Breathing Trial",
        "Intubation",
        "Mechanical Ventilation",
        "Music Therapy"
      ],
      "interventions": [
        {
          "name": "Music therapy plus standard care during an SBT",
          "type": "OTHER"
        },
        {
          "name": "Standard care during an SBT",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2021-08-30",
      "completion_date": "2023-01-01",
      "has_results": false,
      "last_update_posted_date": "2024-10-24",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05008328"
    },
    {
      "nct_id": "NCT06561295",
      "title": "Optimal Timing for Spontaneous Breathing Trials",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiration, Artificial",
        "Weaning"
      ],
      "interventions": [
        {
          "name": "Later Morning Timing of Spontaneous Breathing Trials",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 348,
      "start_date": "2024-09-17",
      "completion_date": "2026-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-09-30",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06561295"
    },
    {
      "nct_id": "NCT01901354",
      "title": "Acute Lung Injury Ventilator Evaluation (ALIVE)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Lung Injury",
        "Adult Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Low-tidal-volume ventilation",
          "type": "OTHER"
        },
        {
          "name": "Airway Pressure Release Ventilation (APRV)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2013-11",
      "completion_date": "2014-10",
      "has_results": false,
      "last_update_posted_date": "2017-09-28",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01901354"
    },
    {
      "nct_id": "NCT04372953",
      "title": "Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lung Injury",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "Positive End-Expiratory Pressure (PEEP)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Murdoch Childrens Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 28 Weeks"
      },
      "enrollment_count": 906,
      "start_date": "2021-05-04",
      "completion_date": "2028-05-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 4,
      "location_summary": "Little Rock, Arkansas • San Diego, California • Indianapolis, Indiana + 1 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04372953"
    },
    {
      "nct_id": "NCT03901924",
      "title": "Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Ventilation Complication"
      ],
      "interventions": [
        {
          "name": "Volume Support Mode Mechanical Ventilation",
          "type": "OTHER"
        },
        {
          "name": "Assist Control Mode Mechanical Ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 468,
      "start_date": "2019-03-04",
      "completion_date": "2027-05",
      "has_results": false,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Iowa City, Iowa",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03901924"
    },
    {
      "nct_id": "NCT05204719",
      "title": "Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "Prophylactic Delivery Room Continuous Positive Airway Pressure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Minute",
        "maximum_age": "5 Minutes",
        "sex": "ALL",
        "summary": "1 Minute to 5 Minutes"
      },
      "enrollment_count": 120,
      "start_date": "2023-08-04",
      "completion_date": "2026-04-14",
      "has_results": false,
      "last_update_posted_date": "2026-06-17",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 3,
      "location_summary": "Indianapolis, Indiana • St Louis, Missouri • Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05204719"
    },
    {
      "nct_id": "NCT04821453",
      "title": "NAVA vs. CMV Crossover in Severe BPD",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchopulmonary Dysplasia",
        "Neurally Adjusted Ventilatory Assist",
        "Mechanical Ventilation"
      ],
      "interventions": [
        {
          "name": "NAVA",
          "type": "DEVICE"
        },
        {
          "name": "CMV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Months",
        "sex": "ALL",
        "summary": "Up to 24 Months"
      },
      "enrollment_count": 12,
      "start_date": "2021-09-13",
      "completion_date": "2025-02-28",
      "has_results": true,
      "last_update_posted_date": "2026-05-20",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 2,
      "location_summary": "Philadelphia, Pennsylvania • Providence, Rhode Island",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04821453"
    },
    {
      "nct_id": "NCT01782755",
      "title": "Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ventilator Associated Pneumonia (VAP)",
        "Other Infections",
        "Antibiotic-Associated Diarrhea",
        "C-Difficile",
        "Duration of Mechanical Ventilation",
        "Length of ICU Stay",
        "Length of Hospital Stay",
        "ICU and Hospital Mortality"
      ],
      "interventions": [
        {
          "name": "L. rhamnosus GG - Probiotic",
          "type": "DRUG"
        },
        {
          "name": "Placebo - Microcrystalline Cellulose",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "McMaster University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2013-10",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2019-08-28",
      "last_synced_at": "2026-09-23T13:36:27.973Z",
      "location_count": 2,
      "location_summary": "Rochester, Minnesota • St Louis, Missouri",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01782755"
    }
  ]
}