{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=tVNS+stimulation",
    "query": {
      "intervention": "tVNS stimulation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 44,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=tVNS+stimulation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-09T08:52:19.012Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03959111",
      "title": "Auricular Vagus Nerve Stimulation for Chronic Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Stimulation at Location 1",
          "type": "OTHER"
        },
        {
          "name": "Stimulation at Location 2",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 70,
      "start_date": "2019-10-17",
      "completion_date": "2024-04-30",
      "has_results": true,
      "last_update_posted_date": "2026-03-11",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03959111"
    },
    {
      "nct_id": "NCT05602779",
      "title": "Leverage Noninvasive Transcutaneous Vagus Nerve Stimulation to Reduce Suicidal Behaviors in Vulnerable Adolescents",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Self Harm",
        "Suicidal Ideation"
      ],
      "interventions": [
        {
          "name": "tVNS Program",
          "type": "DEVICE"
        },
        {
          "name": "Phone App Program",
          "type": "OTHER"
        },
        {
          "name": "tVNS and Phone App Program",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Sham tNVS and Control App",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER",
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "University of Notre Dame",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "13 Years to 17 Years"
      },
      "enrollment_count": 200,
      "start_date": "2024-11-15",
      "completion_date": "2027-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-17",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 2,
      "location_summary": "South Bend, Indiana • Rochester, New York",
      "locations": [
        {
          "city": "South Bend",
          "state": "Indiana"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05602779"
    },
    {
      "nct_id": "NCT07470229",
      "title": "Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stress Response"
      ],
      "interventions": [
        {
          "name": "Transcutaneous Vagus Nerve Stimulation (tVNS)",
          "type": "DEVICE"
        },
        {
          "name": "Evaluative Stress Task",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 200,
      "start_date": "2026-03-15",
      "completion_date": "2026-04-15",
      "has_results": false,
      "last_update_posted_date": "2026-03-13",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07470229"
    },
    {
      "nct_id": "NCT05218109",
      "title": "Stress and Sleep Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stress, Psychological",
        "Sleep",
        "Transcutaneous Electric Nerve Stimulation",
        "Vagus Nerve Stimulation",
        "Mindfulness"
      ],
      "interventions": [
        {
          "name": "tVNS",
          "type": "DEVICE"
        },
        {
          "name": "Mindfulness",
          "type": "BEHAVIORAL"
        },
        {
          "name": "sham tVNS",
          "type": "DEVICE"
        },
        {
          "name": "Number Puzzle",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 76,
      "start_date": "2022-02-09",
      "completion_date": "2023-05-29",
      "has_results": true,
      "last_update_posted_date": "2024-04-04",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05218109"
    },
    {
      "nct_id": "NCT06009159",
      "title": "Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fibromyalgia"
      ],
      "interventions": [
        {
          "name": "Transcutaneous Vagus Nerve Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2024-07-01",
      "completion_date": "2026-10-31",
      "has_results": false,
      "last_update_posted_date": "2025-05-06",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06009159"
    },
    {
      "nct_id": "NCT06335199",
      "title": "tVNS Responsiveness Testing With Pupil Size",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Unilateral Left tVNS stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "Bilateral tVNS stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "Unilateral Left Sham stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "Bilateral Sham stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "Unilateral Right tVNS stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "Unilateral Right Sham stimulation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Georgia Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 21,
      "start_date": "2024-11-14",
      "completion_date": "2025-10-27",
      "has_results": false,
      "last_update_posted_date": "2025-10-29",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06335199"
    },
    {
      "nct_id": "NCT04099992",
      "title": "Mindfulness in Chronic Kidney Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Kidney Diseases"
      ],
      "interventions": [
        {
          "name": "Mindfulness-based stress reduction (MBSR)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Health enhancement program (HEP)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transcutaneous Vagus Nerve Stimulation (tVNS)",
          "type": "DEVICE"
        },
        {
          "name": "Sham-transcutaneous Vagus Nerve Stimulation (tVNS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 150,
      "start_date": "2019-09-20",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2025-10-21",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04099992"
    },
    {
      "nct_id": "NCT05750108",
      "title": "Transcutaneous Vagal Nerve Stimulation to Prevent Tachyarrhythmias in Patients Early Following Myocardial Infarction",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myocardial Infarction",
        "Tachyarrhythmia"
      ],
      "interventions": [
        {
          "name": "Parasym device (active, current (mA) < discomfort threshold)",
          "type": "DEVICE"
        },
        {
          "name": "Parasym device (sham, current (mA) = 0)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Hippocration General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2023-06",
      "completion_date": "2024-12",
      "has_results": false,
      "last_update_posted_date": "2023-03-01",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05750108"
    },
    {
      "nct_id": "NCT07782866",
      "title": "MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Breast Cancer"
      ],
      "interventions": [
        {
          "name": "Transcutaneous vagus nerve and acupuncture point stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The Healing Consciousness Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 46,
      "start_date": "2025-04-14",
      "completion_date": "2026-07-24",
      "has_results": false,
      "last_update_posted_date": "2026-08-24",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Meadowbrook, Pennsylvania",
      "locations": [
        {
          "city": "Meadowbrook",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07782866"
    },
    {
      "nct_id": "NCT04607226",
      "title": "Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Active transcutaneous vagus nerve stimulation",
          "type": "OTHER"
        },
        {
          "name": "Sham transcutaneous vagus nerve stimulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "24 Years to 45 Years · Female only"
      },
      "enrollment_count": 15,
      "start_date": "2020-11-02",
      "completion_date": "2022-10-12",
      "has_results": false,
      "last_update_posted_date": "2023-08-01",
      "last_synced_at": "2026-09-09T08:52:19.012Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04607226"
    }
  ]
}