{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=tramadol+HCL", "query": { "intervention": "tramadol HCL" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 13, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=tramadol+HCL&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-04T20:27:38.600Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05488847", "title": "Opioid-Free Pain Protocol After Shoulder Arthroplasty", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Shoulder Arthropathy", "Shoulder Pain" ], "interventions": [ { "name": "Celecoxib", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Ropivicaine", "type": "DRUG" }, { "name": "Epinephrine", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Tizanidine", "type": "DRUG" }, { "name": "Magnesium", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Oxycodone Hydrochloride 5 Mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Henry Ford Health System", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 83, "start_date": "2022-06-25", "completion_date": "2026-09-01", "has_results": true, "last_update_posted_date": "2026-02-10", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Detroit, Michigan", "locations": [ { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT05488847" }, { "nct_id": "NCT03586934", "title": "Multimodal Analgesia in Shoulder Arthroplasty", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Shoulder Pain", "Opioid Use" ], "interventions": [ { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Celecoxib 200mg", "type": "DRUG" }, { "name": "Celecoxib 400 mg", "type": "DRUG" }, { "name": "Ropivacaine", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Acetaminophen Injectable Product", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Morphine Injectable Solution", "type": "DRUG" }, { "name": "hydrocodone bitartrate and acetaminophen", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" }, { "name": "Oxycodone Hydrochloride", "type": "DRUG" }, { "name": "Meloxicam", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Rush University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2018-06-01", "completion_date": "2019-06-01", "has_results": false, "last_update_posted_date": "2021-09-28", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03586934" }, { "nct_id": "NCT00325858", "title": "A Study Comparing the Effectiveness and Safety of Varying Dose Strengths (100, 200, 300 and 400 mg) of Extended-release Tramadol HCl With Placebo for the Treatment of Osteoarthritis(OA) of the Knee and/or Hip", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Pain" ], "interventions": [ { "name": "Tramadol HCl ER", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bausch Health Americas, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 1000, "start_date": "2002-01", "completion_date": "2003-12", "has_results": false, "last_update_posted_date": "2012-08-27", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Duncansville, Pennsylvania", "locations": [ { "city": "Duncansville", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00325858" }, { "nct_id": "NCT00662558", "title": "A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Low Back Pain" ], "interventions": [ { "name": "celecoxib", "type": "DRUG" }, { "name": "tramadol HCL", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 802, "start_date": "2008-01", "completion_date": "2008-09", "has_results": true, "last_update_posted_date": "2021-02-21", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 60, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 49 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00662558" }, { "nct_id": "NCT00290901", "title": "Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Back Pain" ], "interventions": [ { "name": "Tramadol Hydrochloride 50mg", "type": "DRUG" }, { "name": "Celebrex 200mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 754, "start_date": "2006-03", "completion_date": null, "has_results": false, "last_update_posted_date": "2021-03-03", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 53, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Tucson, Arizona + 50 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00290901" }, { "nct_id": "NCT01267136", "title": "A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Tonsillitis", "Pain" ], "interventions": [ { "name": "Codeine with acetaminophen", "type": "DRUG" }, { "name": "Tramadol suspension", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Children's Hospitals and Clinics of Minnesota", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "4 Years", "maximum_age": "15 Years", "sex": "ALL", "summary": "4 Years to 15 Years" }, "enrollment_count": 84, "start_date": "2011-01", "completion_date": "2012-05", "has_results": true, "last_update_posted_date": "2014-04-17", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Minneapolis, Minnesota", "locations": [ { "city": "Minneapolis", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT01267136" }, { "nct_id": "NCT01947920", "title": "A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Tramadol HCl, 50 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Scientific Affairs, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 30, "start_date": "2013-08", "completion_date": "2013-11", "has_results": false, "last_update_posted_date": "2014-12-16", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01947920" }, { "nct_id": "NCT01943435", "title": "Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lumbar Spinal Stenosis" ], "interventions": [ { "name": "NSAIDs; adjunctive analgesics; adjunctive anti-depressants", "type": "DRUG" }, { "name": "Lumbar epidural injection", "type": "PROCEDURE" }, { "name": "Joint Mobilizations (spine, sacroiliac, hip)", "type": "OTHER" }, { "name": "Individualized exercises: clinical setting", "type": "OTHER" }, { "name": "Group Exercise: community setting", "type": "OTHER" } ], "intervention_types": [ "DRUG", "PROCEDURE", "OTHER" ], "sponsor": "Michael Schneider, DC, PhD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 259, "start_date": "2013-11-20", "completion_date": "2016-06-10", "has_results": true, "last_update_posted_date": "2018-04-02", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01943435" }, { "nct_id": "NCT02307864", "title": "Study to Evaluate the Effects of Tramadol Hydrochloride on Cardiac Repolarization in Healthy Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Tramadol HCl", "type": "DRUG" }, { "name": "Moxifloxacin 400 mg", "type": "DRUG" }, { "name": "Tramadol HCl Placebo", "type": "DRUG" }, { "name": "Moxifloxacin Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Scientific Affairs, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 68, "start_date": "2014-12-04", "completion_date": "2015-08-27", "has_results": false, "last_update_posted_date": "2018-08-29", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02307864" }, { "nct_id": "NCT06340932", "title": "Impact of Opioid Avoidance Protocol for ACL Reconstruction", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "ACL Tear", "Post Operative Pain" ], "interventions": [ { "name": "Iovera", "type": "DEVICE" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Bupivacaine Hydrochloride", "type": "DRUG" }, { "name": "Acetaminophen 500Mg Cap", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Matthew Varacallo", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "15 Years", "maximum_age": null, "sex": "ALL", "summary": "15 Years and older" }, "enrollment_count": 32, "start_date": "2024-04-27", "completion_date": "2025-02-01", "has_results": false, "last_update_posted_date": "2025-03-07", "last_synced_at": "2026-09-04T20:27:38.600Z", "location_count": 1, "location_summary": "DuBois, Pennsylvania", "locations": [ { "city": "DuBois", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06340932" } ] }