{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=zyban&page=3", "query": { "intervention": "zyban", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 359, "total_pages": 36, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=zyban&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=zyban&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-03T12:30:17.911Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06098079", "title": "Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "Naltrexone-Bupropion (NB) Combination", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Currax Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 8600, "start_date": "2024-01-03", "completion_date": "2029-07", "has_results": false, "last_update_posted_date": "2026-03-31", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 140, "location_summary": "Birmingham, Alabama • Cullman, Alabama • Mobile, Alabama + 111 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Cullman", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT06098079" }, { "nct_id": "NCT02332291", "title": "Connectivity Affecting the Antidepressant REsponse Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Escitalopram", "type": "DRUG" }, { "name": "Bupropion XL", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 95, "start_date": "2015-04", "completion_date": "2020-08", "has_results": true, "last_update_posted_date": "2021-09-21", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02332291" }, { "nct_id": "NCT01156610", "title": "Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Smoking", "Smoking Cessation" ], "interventions": [ { "name": "Tobacco Treatment", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 706, "start_date": "2011-11", "completion_date": "2014-03", "has_results": false, "last_update_posted_date": "2014-03-06", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 2, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01156610" }, { "nct_id": "NCT02994082", "title": "Treating Smokeless Tobacco Use in Rural Veterans", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Smokeless Tobacco", "Nicotine Dependence" ], "interventions": [ { "name": "Tailored behavioral intervention", "type": "BEHAVIORAL" }, { "name": "Behavioral activation for elevated depressive symptoms", "type": "BEHAVIORAL" }, { "name": "Post-cessation weight gain management", "type": "BEHAVIORAL" }, { "name": "Alcohol use risk reduction", "type": "BEHAVIORAL" }, { "name": "Nicotine replacement therapy - transdermal nicotine patch", "type": "DRUG" }, { "name": "Nicotine replacement therapy - nicotine lozenge", "type": "DRUG" }, { "name": "Nicotine replacement therapy - nicotine gum", "type": "DRUG" }, { "name": "Bupropion sustained release", "type": "DRUG" }, { "name": "Varenicline", "type": "DRUG" }, { "name": "Combination nicotine replacement therapy", "type": "DRUG" }, { "name": "Combination nicotine replacement therapy + bupropion", "type": "DRUG" }, { "name": "Tobacco quit line", "type": "BEHAVIORAL" }, { "name": "Educational materials", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "Mark Vander Weg", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 123, "start_date": "2016-12", "completion_date": "2020-05", "has_results": false, "last_update_posted_date": "2019-07-24", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 1, "location_summary": "Iowa City, Iowa", "locations": [ { "city": "Iowa City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT02994082" }, { "nct_id": "NCT00033592", "title": "Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Lung Cancer" ], "interventions": [ { "name": "placebo", "type": "OTHER" }, { "name": "bupropion hydrochloride", "type": "DRUG" }, { "name": "nicotine", "type": "DRUG" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "Alliance for Clinical Trials in Oncology", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1708, "start_date": "2002-02", "completion_date": "2006-07", "has_results": false, "last_update_posted_date": "2016-07-13", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 24, "location_summary": "Scottsdale, Arizona • Washington D.C., District of Columbia • Peoria, Illinois + 20 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Peoria", "state": "Illinois" }, { "city": "Urbana", "state": "Illinois" }, { "city": "Cedar Rapids", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT00033592" }, { "nct_id": "NCT00177567", "title": "Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "lithium carbonate", "type": "DRUG" }, { "name": "Depakote-ER", "type": "DRUG" }, { "name": "risperidone", "type": "DRUG" }, { "name": "olanzapine", "type": "DRUG" }, { "name": "paroxetine", "type": "DRUG" }, { "name": "bupropion", "type": "DRUG" }, { "name": "lamotrigine", "type": "DRUG" }, { "name": "venlafaxine", "type": "DRUG" }, { "name": "tranylcypromine", "type": "DRUG" }, { "name": "mirtazapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pittsburgh", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 60, "start_date": "2001-07", "completion_date": "2004-01", "has_results": false, "last_update_posted_date": "2005-09-15", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 2, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00177567" }, { "nct_id": "NCT00141206", "title": "A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Smoking Cessation" ], "interventions": [ { "name": "varenicline (CP-526,555)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 1005, "start_date": "2003-05", "completion_date": "2005-04", "has_results": false, "last_update_posted_date": "2007-06-04", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 20, "location_summary": "Tucson, Arizona • Los Angeles, California • Newport Beach, California + 17 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00141206" }, { "nct_id": "NCT00079469", "title": "Bupropion and Counseling With or Without Contingency Management to Enhance Smoking Cessation in Treating Cancer Survivors Who Continue to Smoke", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cancer Survivor", "Unspecified Adult Solid Tumor, Protocol Specific" ], "interventions": [ { "name": "smoking cessation intervention", "type": "BEHAVIORAL" }, { "name": "bupropion hydrochloride", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "National Institutes of Health Clinical Center (CC)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": null, "start_date": "2004-02", "completion_date": "2004-08", "has_results": false, "last_update_posted_date": "2012-03-08", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 1, "location_summary": "Rockville, Maryland", "locations": [ { "city": "Rockville", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00079469" }, { "nct_id": "NCT00419731", "title": "Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Tobacco Use Disorder" ], "interventions": [ { "name": "Bupropion", "type": "DRUG" }, { "name": "Bupropion + Naltrexone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Minnesota", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 120, "start_date": "2006-11", "completion_date": "2010-07", "has_results": false, "last_update_posted_date": "2009-12-03", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 1, "location_summary": "Minneapolis, Minnesota", "locations": [ { "city": "Minneapolis", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT00419731" }, { "nct_id": "NCT00125957", "title": "The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depression", "Major Depressive Disorder", "Unipolar Depression" ], "interventions": [ { "name": "Wellbutrin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mclean Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 32, "start_date": "2005-08", "completion_date": "2011-12", "has_results": true, "last_update_posted_date": "2014-08-06", "last_synced_at": "2026-10-03T12:30:17.911Z", "location_count": 1, "location_summary": "Belmont, Massachusetts", "locations": [ { "city": "Belmont", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00125957" } ] }