{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?page=5&sponsor=National+Human+Genome+Research+Institute+%28NHGRI%29", "query": { "sponsor": "National Human Genome Research Institute (NHGRI)", "page": 5 }, "page_size": 10 }, "pagination": { "page": 5, "page_size": 10, "total_count": 258, "total_pages": 26, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?page=6&sponsor=National+Human+Genome+Research+Institute+%28NHGRI%29&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?page=4&sponsor=National+Human+Genome+Research+Institute+%28NHGRI%29&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-18T00:14:06.242Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01852071", "title": "Autologous CD34+ Hematopoietic Stem Cells Transduced ex Vivo With Elongation Factor 1 Alpha Shortened (EFS) Lentiviral Vector Encoding for the Human ADA Gene", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "ADA-SCID" ], "interventions": [ { "name": "Infusion of autologous EFS-ADA LV CD34+ (OTL-101)", "type": "GENETIC" }, { "name": "busulfan", "type": "DRUG" }, { "name": "PEG-ADA ERT", "type": "DRUG" } ], "intervention_types": [ "GENETIC", "DRUG" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Month", "maximum_age": "17 Years", "sex": "ALL", "summary": "1 Month to 17 Years" }, "enrollment_count": 46, "start_date": "2013-08-02", "completion_date": "2018-08-27", "has_results": true, "last_update_posted_date": "2022-08-03", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 2, "location_summary": "Los Angeles, California • Bethesda, Maryland", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01852071" }, { "nct_id": "NCT05966129", "title": "A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acute Pain" ], "interventions": [ { "name": "Pharmacogenetic testing", "type": "OTHER" }, { "name": "Clinical decisions support", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "8 Years", "maximum_age": null, "sex": "ALL", "summary": "8 Years and older" }, "enrollment_count": 1602, "start_date": "2021-03-10", "completion_date": "2024-03-25", "has_results": true, "last_update_posted_date": "2026-03-19", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 11, "location_summary": "Wilmington, Delaware • Gainesville, Florida • Jacksonville, Florida + 6 more", "locations": [ { "city": "Wilmington", "state": "Delaware" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT05966129" }, { "nct_id": "NCT00359580", "title": "Genetic Studies in the Amish and Mennonites", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Genetic Disease" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 157, "start_date": "2004-02-10", "completion_date": "2014-07-07", "has_results": false, "last_update_posted_date": "2026-06-03", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 2, "location_summary": "Bethesda, Maryland • Strasburg, Pennsylvania", "locations": [ { "city": "Bethesda", "state": "Maryland" }, { "city": "Strasburg", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00359580" }, { "nct_id": "NCT00669188", "title": "Patient Provider Communication and Interaction in a Virtual Clinical Setting", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Healthy Volunteer" ], "interventions": [ { "name": "Information absent", "type": "OTHER" }, { "name": "Information", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 326, "start_date": "2008-04-24", "completion_date": "2020-07-08", "has_results": false, "last_update_posted_date": "2024-08-12", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00669188" }, { "nct_id": "NCT04371432", "title": "Genetics of COVID-19 Susceptibility and Manifestations", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "COVID-19", "Coronavirus 2019" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Month", "maximum_age": "110 Years", "sex": "ALL", "summary": "1 Month to 110 Years" }, "enrollment_count": 721, "start_date": "2020-05-05", "completion_date": "2024-12-15", "has_results": false, "last_update_posted_date": "2026-08-21", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04371432" }, { "nct_id": "NCT04417673", "title": "Living With Sickle Cell Disease in the COVID-19 Pandemic", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Isolation", "Anxiety", "Health Care Utilization", "Sickle Cell Disease", "Pain" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 186, "start_date": "2020-06-15", "completion_date": "2022-05-18", "has_results": false, "last_update_posted_date": "2026-06-10", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04417673" }, { "nct_id": "NCT06748040", "title": "Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Chronic Kidney Disease", "Hypertension" ], "interventions": [ { "name": "Timing of return of results", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 1874, "start_date": "2020-07-10", "completion_date": "2024-05-17", "has_results": true, "last_update_posted_date": "2025-06-17", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 8, "location_summary": "Birmingham, Alabama • Gainesville, Florida • Jacksonville, Florida + 3 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06748040" }, { "nct_id": "NCT00341159", "title": "Analysis of Data From the Women's Contraceptive and Reproductive Experiences (CARE) Study", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Breast Cancer" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "35 Years to 64 Years" }, "enrollment_count": 9257, "start_date": "2005-01-18", "completion_date": "2015-02-24", "has_results": false, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00341159" }, { "nct_id": "NCT06092346", "title": "A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "AMPD3, OMIM*102772, AMP Deaminase Deficiency", "AK1, OMIM *103000, Adenylate Kinase Deficiency", "AMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency", "TPMT, OMIM *187680, Thoipurines, Poor Metabolism of", "IMPDH1, OMIM *146690, Retinitis Pigmentosa Type 10, Leber Congenital Amauriosis Type 11", "APRT, OMIM *102600, Adenine Phosphoribosyltransferase Deficiency", "HPRT1, OMIM *308000 Lesch-Nyhan Disease", "XDH, OMIM *607633, Xanthinuria Type 1", "SLC2A9, OMIM *606142 Hypouricemia", "SLC22A12, OMIM *607096 Hypouricemia", "PRPS1 Def, OMIM *311850, Arts Syndrome; Charcot-Marie-Tooth Disease", "PRPS1 SA, OMIM *311850 Gout, PRPS-related Phosphoribosylpyrophosphate Synthetase Superactivity", "AMPD2, OMIM *102771, Spastic Paraplegia 63; Pontocerebellar Hypoplasia", "ITPA, OMIM *147520, Inosine Triphosphatase Deficiency; Developmental and Epileptic Encephalopathy 35", "ADSL, OMIM *608222, Adenylosuccinate Lyase Deficiency", "PNP, OMIM *164050, Nucleoside Phosphorylase Deficiency", "ADA2, OMIM *607575,Sneddon Syndrome; VAIHS", "CAD, *1140120, Developmental and Epileptic Encephalopathy", "UPB1, OMIM *606673, Beta-ureidopropionase Deficiency", "DPYS, OMIM *613326, Dihydropyrimidinase Deficiency", "DPYD, OMIM *274270, Dihydropyrimidine Dehydrogenase Deficiency", "DHODH, OMIM *126064, Miller Syndrome (Postaxial Acrofacial Dysostosis)", "UMPS, OMIM *613891, Orotic Aciduria", "NT5C3A, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency", "UNG, OMIM *191525, Hyper-IgM Syndrome 5", "AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2", "Purine-Pyrimidine Metabolism", "Metabolic Disease" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Month", "maximum_age": "100 Years", "sex": "ALL", "summary": "1 Month to 100 Years" }, "enrollment_count": 999, "start_date": "2023-12-19", "completion_date": "2099-01-01", "has_results": false, "last_update_posted_date": "2026-08-19", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT06092346" }, { "nct_id": "NCT00369421", "title": "Diagnosis and Treatment of Patients With Inborn Errors of Metabolism", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Arterial Calcification Due to Deficiency of CD73" ], "interventions": [], "intervention_types": [], "sponsor": "National Human Genome Research Institute (NHGRI)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "1 Month", "maximum_age": "115 Years", "sex": "ALL", "summary": "1 Month to 115 Years" }, "enrollment_count": 4000, "start_date": "1978-09-12", "completion_date": null, "has_results": false, "last_update_posted_date": "2026-10-13", "last_synced_at": "2026-10-18T00:14:06.242Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00369421" } ] }