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Showing 1–24 of 227 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Anterior Cruciate Ligament Injury
Interventions
Electrical Stimulation, Eccentric Exercise
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Interventions
dispense of study drug, Ketorolac
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
15 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Coral Springs, Florida • Garfield, Ohio • Strongsville, Ohio
Completed Not applicable Interventional

BFRT MPFL and ACL Reconstruction Rehab

NCT05426954
Conditions
Medial Patellar Femoral Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation utilizing blood flow restrictive therapy
Other
Lead sponsor
Richard Watson, PT
Other
Eligibility
13 Years to 40 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Terminated Not applicable Interventional

Playmaker 3D Printed Knee Extender

NCT05878652
Conditions
ACL, ACL Injury
Interventions
3D printed knee extender device, Standard Prehabilitation Education
Device · Other
Lead sponsor
Sanford Health
Other
Eligibility
14 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Fargo, North Dakota • Sioux Falls, South Dakota
Conditions
Knee Injuries, Anterior Cruciate Ligament Injuries
Interventions
Blood Flow Restriction Therapy, Standard Postoperative Physical Therapy
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Redwood City, California
Conditions
Anterior Cruciate Ligament Tear
Interventions
Regenexx SD, Exercise Therapy
Procedure · Other
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Broomfield, Colorado
Conditions
Rehabilitation, ACL Reconstruction
Interventions
HOME, TNMT
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 30 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
4
States / cities
Flowery Branch, Georgia • Minneapolis, Minnesota • Rochester, Minnesota + 1 more
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
iovera°
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 49 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
10 Years to 80 Years
Enrollment
3,294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2028
U.S. locations
8
States / cities
Boulder, Colorado • Iowa City, Iowa • St Louis, Missouri + 5 more
Conditions
Anterior Cruciate Ligament (ACL) Tear
Interventions
Single-injection sciatic PNB, Continuous sciatic PNB
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 18 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Completed Phase 4 Interventional Results available

ACL Repair and Multimodal Analgesia

NCT01868425
Conditions
Pain
Interventions
multimodal:acetaminophen, gabapentin, ketamine, bupivacaine, placebo pills and injectables
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 55 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Continuous Vs Single Shot Block After ACL

NCT04101682
Conditions
ACL Injury
Interventions
Bupivacaine
Drug
Lead sponsor
Northwell Health
Other
Eligibility
16 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Plainview, New York
Conditions
ACL Injury
Interventions
PET scan, MRI scan
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 60 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
ACL Repair, Meniscectomy, Bankart Repair
Interventions
Bupivacaine
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 19 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Anterior Cruciate Ligament Rupture
Interventions
BioCleanse Tibialis tendon
Other
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Accepts healthy volunteers

Use of Blood Flow Restriction Therapy Following ACL Tear

NCT04374968
Conditions
Anterior Cruciate Ligament Tear, Knee Injuries, Sport Injury
Interventions
Blood flood restriction cuff
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
West Bloomfield, Michigan
Conditions
ACL - Anterior Cruciate Ligament Rupture, ACL Injury
Interventions
Platelet Rich Plasma, Saline Placebo
Biological · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Conditions
ACL Tear, ACL Injury, Arthroscopy, Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction with bone marrow, demineralized bone marix, and internal brace augmentation, Standard ACL reconstruction with all inside technique
Procedure
Lead sponsor
Marshall University
Other
Eligibility
14 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Huntington, West Virginia
Conditions
Anterior Cruciate Ligament Injury
Interventions
Neuromuscular Prevention Program
Other
Lead sponsor
High Point University
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
High Point, North Carolina
Completed Not applicable Interventional Accepts healthy volunteers

Effects of HMB Supplementation on Recovery Following ACL Surgery

NCT02602561
Conditions
ACL Injury
Interventions
HMB, Placebo
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ames, Iowa
Completed No phase listed Observational Accepts healthy volunteers

Gabapentin Premedication for ACL Reconstruction: RCT

NCT03417479
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction
Interventions
Gabapentin
Other
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Tranexamic Acid
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 60 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Conditions
ACL Injury
Interventions
Exercise Blood Flow Restriction training, SHAM Exercise Blood Flow Restriction training
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Scottsdale, Arizona
Conditions
Knee Osteoarthristis, ACL Injuries, Post-Traumatic
Interventions
extracorporeal shockwave therapy (ESWT), Sham Comparator
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts