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ClinicalTrials.gov public records Last synced May 22, 2026, 4:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: ACL Reconstruction Clear all
Completed Not applicable Interventional
View directory record Official record
Conditions
Medial Patellar Femoral Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation utilizing blood flow restrictive therapy
Other
Lead sponsor
Richard Watson, PT
Other
Eligibility
13 Years to 40 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced May 22, 2026, 4:11 AM EDT
Withdrawn Not applicable Interventional
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced May 22, 2026, 4:11 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
Interventions
Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
Device
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
16 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced May 22, 2026, 4:11 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
13 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced May 22, 2026, 4:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced May 22, 2026, 4:11 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
Interventions
Werewolf FLOW 50, Control
Device · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 18 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Aurora, Colorado • Broomfield, Colorado • Highlands Ranch, Colorado
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced May 22, 2026, 4:11 AM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Autologous Bone Marrow Derived Mesenchymal Stem Cells, Sham incision
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
ACL Injury, Postoperative Pain
Interventions
Ketorolac, Oxycodone-Acetaminophen
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced May 22, 2026, 4:11 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
ACL Repair
Interventions
Cryoneurolysis
Procedure
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
14 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Burlington, New Jersey • Cherry Hill, New Jersey
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 22, 2026, 4:11 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine HCl 0.5% Injectable Solution, Dexamethasone, Infiltration between Popliteal Artery and Capsule of the knee (iPACK), Percocet 5Mg-325Mg Tablet
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced May 22, 2026, 4:11 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
ACL Tear, ACL Injury, Arthroscopy, Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction with bone marrow, demineralized bone marix, and internal brace augmentation, Standard ACL reconstruction with all inside technique
Procedure
Lead sponsor
Marshall University
Other
Eligibility
14 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced May 22, 2026, 4:11 AM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Focused Shockwave, Sham Focused Shockwave
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 22, 2026, 4:11 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Arthroscopic Surgical Procedures, Anterior Cruciate Ligament Reconstruction
Interventions
Activated Incrediwear Products, Sham Incrediwear Products
Other
Lead sponsor
Oklahoma Joint Reconstruction Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
ACL Injury, Post Operative Pain
Interventions
Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced May 22, 2026, 4:11 AM EDT
Recruiting Phase 4 Interventional
View directory record Official record
Conditions
Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions
IPACK, PLACEBO
Drug
Lead sponsor
Loyola University
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Oxycodone, Placebo oral tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
14 Years to 40 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia • Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 3 Interventional
View directory record Official record
Conditions
Knee Injuries
Interventions
OMS103HP, Vehicle
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
15 Years to 65 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
15
States / cities
Encinitas, California • Denver, Colorado • Englewood, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2012 · Synced May 22, 2026, 4:11 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Pain, Postoperative
Interventions
oxycodone
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
Not listed
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced May 22, 2026, 4:11 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
ACL Tear, Opioid Misuse, Pain, Anxiety
Interventions
Exparel
Drug
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
7 Years to 17 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Bio-ACL, amnion wrap and BMAC
Procedure · Device
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced May 22, 2026, 4:11 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
ACL Injury
Interventions
Exercise Blood Flow Restriction training, SHAM Exercise Blood Flow Restriction training
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced May 22, 2026, 4:11 AM EDT
Terminated Phase 4 Interventional Results available
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Bupivacaine, Preservative free normal saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 70 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced May 22, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
IPACK block
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced May 22, 2026, 4:11 AM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
ACL Reconstruction
Interventions
Mental Skills Training (MST)
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
8 Years to 25 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced May 22, 2026, 4:11 AM EDT