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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Abortion, First Trimester Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lidocaine and Pain Management in First Trimester Abortions

NCT00613821
View directory record Official record
Conditions
Pain
Interventions
Lidocaine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 30, 2017 · Synced Sep 23, 2026, 3:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Preferences in Anesthesia for Abortion Care

NCT03030443
View directory record Official record
Conditions
Pregnancy Termination in First Trimester
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Sep 23, 2026, 3:27 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)

NCT00337792
View directory record Official record
Conditions
Undesired Pregnancy
Interventions
oxycodone + lorazepam versus fentanyl + midazolam
Drug
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management of First Trimester Surgical Abortion

NCT02096575
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Nitrous oxide administration
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Results available

Pain Control In First Trimester Medical Abortion: A Randomized Trial

NCT01457521
View directory record Official record
Conditions
Pain
Interventions
Ibuprofen
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Self-Administered Lidocaine Gel for Pain Management With First Trimester Surgical Abortion: A Randomized Controlled Trial

NCT02447029
View directory record Official record
Conditions
Pregnancy, Unwanted
Interventions
vaginal 2% Xylocaine, standard lidocaine paracervical block
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Paracervical Block for Pain Control in First Trimester Abortion

NCT01094366
View directory record Official record
Conditions
Legal Abortion With Complication, Pain
Interventions
Paracervical Block, Sham Paracervical Block
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Use of Music for Pain and Anxiety Control During Abortion

NCT01013363
View directory record Official record
Conditions
Pain, Anxiety
Interventions
iPod Nano digital music player
Other
Lead sponsor
Columbia University
Other
Eligibility
Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2012 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Nerve Stimulation for Pain Control During First-trimester Abortion

NCT05320432
View directory record Official record
Conditions
Abortion in First Trimester, Pain
Interventions
Transcutaneous electrical nerve stimulation (TENS), Sham
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions

NCT02756403
View directory record Official record
Conditions
First Trimester Abortion
Interventions
Azithromycin, Doxycycline, Metronidazole, Placebo
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 10, 2022 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Not applicable Interventional

Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion

NCT07288047
View directory record Official record
Conditions
Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction, Satisfaction With Care, Anxiety After Surgery
Interventions
VR headset, Usual Care
Device · Other
Lead sponsor
Study Investigator
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Terminated Not applicable Interventional

Choice of Modality of Follow up for Medication Abortion

NCT04056637
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Choice of follow-up option, Multi-level pregnancy test
Other · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Oral Midazolam in First-trimester Surgical Abortions

NCT01830881
View directory record Official record
Conditions
Pain, Anxiety, Nausea
Interventions
Midazolam, Ibuprofen, Placebo-Cherry syrup, Lidocaine
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 24, 2018 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of an Algorithm to Determine IV Sedation Dosing During First-trimester Surgical Abortion

NCT01994317
View directory record Official record
Conditions
Pregnancy, Unplanned
Interventions
Algorithm, Standard care
Other
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2015 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study of Immediate Start of Progestin Contraceptives in Medical Abortion

NCT01902485
View directory record Official record
Conditions
Contraception
Interventions
Timing of Contraceptive Initiation in Medical Abortion
Other
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
937 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
6
States / cities
Chula Vista, California • Eureka, California • Stamford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Phase 4 Interventional

Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions

NCT07542730
View directory record Official record
Conditions
Pain, Abortion, Anxiety
Interventions
Diphenhydramine, Placebo
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Mifepristone vs Misoprostol

NCT06502158
View directory record Official record
Conditions
Cervical Preparation
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Refining Paracervical Block Techniques for Pain Control in First Trimester Surgical Abortion

NCT01466491
View directory record Official record
Conditions
Pain
Interventions
Paracervical block technique with lidocaine
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
332 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 7, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women

NCT00614432
View directory record Official record
Conditions
Blood Loss
Interventions
Not listed
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Honolulu, Hawaii • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacist Provision of Medication Abortion

NCT04956731
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Pharmacist Provision of Medication Abortion
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Randomized Study of Cervical Priming With Misoprostol Prior to Elective First Trimester Pregnancy Termination

NCT00310921
View directory record Official record
Conditions
Abortion, Therapeutic
Interventions
Misoprostol
Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2007 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 2 Interventional

Letrozole and Misoprostol for Early Pregnancy Loss Management

NCT06452719
View directory record Official record
Conditions
Early Pregnancy Loss, Miscarriage in First Trimester, Miscarriage
Interventions
Letrozole, Misoprostol
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss

NCT02141555
View directory record Official record
Conditions
Spontaneous Abortion in First Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Applied Topical Heat as an Adjunct for Pain Control in First-Trimester Surgical Abortionl

NCT02536235
View directory record Official record
Conditions
Topical Heat Application for Intraoperative Abortion Pain Management
Interventions
heat
Other
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
16 Years to 51 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Sep 23, 2026, 3:27 AM EDT