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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alcohol Abstinence Clear all
Completed No phase listed Observational

MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study

NCT03718104
View directory record Official record
Conditions
Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk, Alcohol Use Disorder
Interventions
Pharmacokinetic analysis, Safety and Efficacy, Genetic and epigenetic analysis, Breast milk analysis
Other · Genetic
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts • Carrboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2024 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

StuDy AimED at Increasing AlCohol AbsTinEnce

NCT05778734
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
CM-PST, CM only
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 24 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional Results available

Clinical Intervention in Alcohol Use Disorder

NCT02168400
View directory record Official record
Conditions
Alcohol Use Disorder, Eligible to go Into the MRI Scanner, Short-term Abstinence From Alcohol Use (2 Week Abstinent)
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

NCT01320748
View directory record Official record
Conditions
Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use, Relapse
Interventions
Dual Processing, Relapse Prevention
Behavioral
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Medication Development in Alcoholism: Apremilast Versus Placebo

NCT03175549
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Apremilast, Placebo
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Anxiety During Abstinence in AUD

NCT06793488
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Disulfiram 250 mg, functional MRI
Drug · Diagnostic Test
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

NCT05522075
View directory record Official record
Conditions
Alcohol Drinking, Binge Drinking, Blood Pressure, Alcohol Abstinence, Aging, Lifestyle Factors, Vasodilation, Behavioral Problem
Interventions
Exercise Training, Alcohol Abstinence Intervention
Behavioral
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
50 Years to 64 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Not applicable Interventional

Virtual Incentive Treatment for Alcohol

NCT06265506
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
Interventions
Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional

Remote Monitoring and Contingency Management Reinforcement for Alcohol Abstinence

NCT01307345
View directory record Official record
Conditions
Alcohol Use
Interventions
contingency management for abstinence
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 3 Interventional

Medication and Counseling for Controlled Drinking (Project SMART)

NCT00444418
View directory record Official record
Conditions
Alcohol-related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy
Drug · Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 65 Years · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2013 · Synced Jul 21, 2026, 9:50 AM EDT
Terminated Phase 4 Interventional

CBT-I Augmentation of Medication for Drinking in AUD

NCT04581603
View directory record Official record
Conditions
Alcohol Use Disorder With Insomnia
Interventions
Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Coatesville, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Medication Development in Alcoholism: Acamprosate Versus Naltrexone

NCT00656630
View directory record Official record
Conditions
Alcoholism
Interventions
Acamprosate, Naltrexone, Placebo
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional

A Web Application to Reduce Heavy Drinking in First-time DWI Offenders

NCT02071836
View directory record Official record
Conditions
Driving While Intoxicated, Driving Under the Influence, Heavy Drinking, Alcohol Abstinence
Interventions
Right Turns web application, Treatment as usual
Behavioral
Lead sponsor
Behavior Therapy Associates, LLP
Industry
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Gabapentin for Abstinence Initiation in Alcohol Dependence

NCT01141049
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Gabapentin, Placebo
Drug · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 3 Interventional Results available

The Effects of Quetiapine (Seroquel XR) on Sleep During Alcohol Abstinence

NCT00434876
View directory record Official record
Conditions
Alcoholism, Sleep Initiation and Maintenance Disorders
Interventions
Quetiapine XR, Placebo.
Drug
Lead sponsor
Subhajit Chakravorty
Federal
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Not applicable Interventional

Reset Challenge: Reducing High-risk Drinking for Cancer Prevention

NCT07591428
View directory record Official record
Conditions
Alcohol Drinking, Heavy Drinking, Binge Drinking
Interventions
30-Day Alcohol Abstinence Challenge
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 120 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional

Alkontrol-herbal Effects on Alcohol Drinking

NCT03099590
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Alcohol Abstinence
Interventions
kudzu extract, puerarin, Placebo control
Dietary Supplement
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 60 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment

NCT00288886
View directory record Official record
Conditions
Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence, Substance Abuse
Interventions
Contracting, Prompting and Reinforcement arm, Control arm
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
Jackson, Mississippi • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional

Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management

NCT00350649
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Standard CBT, CBT+CM/adherence, CM/abstinence, CM/abstinence+CBT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 26, 2011 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 4 Interventional

Study of Aripiprazole in Subjects With Alcoholism

NCT00082199
View directory record Official record
Conditions
Alcoholism
Interventions
Aripiprazole, Placebo
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
14
States / cities
Farmington, Connecticut • New Haven, Connecticut • Indianapolis, Indiana + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 10, 2013 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder

NCT01518972
View directory record Official record
Conditions
Alcohol Abuse, Posttraumatic Stress Disorder
Interventions
Prazosin, Placebo medication
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Jul 21, 2026, 9:50 AM EDT
Completed No phase listed Observational

Acamprosate: Genes Associated With Response

NCT00662571
View directory record Official record
Conditions
Alcoholism
Interventions
acamprosate
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
485 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)

NCT03137082
View directory record Official record
Conditions
Alcohol Abstinence
Interventions
Guanfacine XR 3mgs/daily, Placebo (for guanfacine)
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional

Motivational Incentives for Alcohol Abstinence in American Indian and Native Alaskan Adults

NCT02174315
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Contingency Management
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Jul 21, 2026, 9:50 AM EDT