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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ankle Injuries and Disorders Clear all
Completed Early Phase 1 Interventional

Bedside Ultrasound in the Diagnosis of Ankle Fractures in Children

NCT01341015
View directory record Official record
Conditions
Ankle Fracture
Interventions
Ultrasound
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
2 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Jul 21, 2026, 7:28 PM EDT
Withdrawn Not applicable Interventional

Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT05209347
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Recruiting Phase 4 Interventional

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

NCT06949826
View directory record Official record
Conditions
Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions
Buprenorphine Transdermal System, Placebo Patch
Drug
Lead sponsor
Jenna-Leigh Wilson
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Stories to Educate Patients With Ankle, Foot, and Knee Injuries

NCT01810523
View directory record Official record
Conditions
Injury
Interventions
Narrative, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional Results available

An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

NCT03809520
View directory record Official record
Conditions
Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
Interventions
pedCAT
Radiation
Lead sponsor
J L Marsh
Other
Eligibility
18 Years to 70 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated Not applicable Interventional

Weight Change With Controlled Ankle Movement (CAM) Boot Use

NCT05692401
View directory record Official record
Conditions
Ankle Injuries, Foot Injuries and Disorders, Body Weight Changes
Interventions
Nutrition and Exercise Instruction
Behavioral
Lead sponsor
Nell Blake, DPM
Other
Eligibility
18 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

Wright Foot & Ankle Post-Market Observational Study

NCT04118894
View directory record Official record
Conditions
Arthritis, Rheumatoid Arthritis, Fracture, Trauma Injury, Fusion of Joint
Interventions
Foot and Ankle Devices
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Hamilton, New Jersey • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional

A Study Examining Changes in Pain After Manual Therapy in People With Achilles Tendon Pain

NCT06134856
View directory record Official record
Conditions
Achilles Tendinopathy, Ankle Strain, Achilles Tendon Pain, Achilles Tendonitis
Interventions
Ankle mobilization, Sham treatment
Procedure
Lead sponsor
Philadelphia College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional Results available

Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions

NCT00583375
View directory record Official record
Conditions
Foot Fusion
Interventions
Augment® Bone Graft, Standard of Care
Device · Procedure
Lead sponsor
BioMimetic Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
31
States / cities
Tucson, Arizona • San Francisco, California • Santa Cruz, California + 27 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2018 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated Not applicable Interventional Results available

Foot and Ankle Range of Motion (Stretching) Apparatus

NCT00527748
View directory record Official record
Conditions
Plantar Fasciitis, Flatfoot, Calcaneus Fractures
Interventions
Non-Measuring Ankle Exerciser
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

NCT05456295
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Recruiting Not applicable Interventional

Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

NCT03663361
View directory record Official record
Conditions
Ankle Sprains
Interventions
SMART Intervention, Standard of Care Intervention
Other
Lead sponsor
Phillip Gribble
Other
Eligibility
18 Years to 44 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Lexington, Kentucky • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional Results available

Limb Health and Socket Pressure in Response to Powered Ankle Protheses

NCT05112679
View directory record Official record
Conditions
Pressure Ulcer, Ankle, Prosthesis User, Prosthesis Durability, Mobility Limitation, Skin Wound, Amputation; Traumatic, Foot, Amputation, Limb Deficiencies
Interventions
PROPRIO FOOT® by Ossur & Empower ankle by Ottobock
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional

NeoPatch Used as Adjunct in Foot and Ankle Tendon Surgery

NCT03307499
View directory record Official record
Conditions
Tendinopathy, Tendon Tear, Tendon Injuries, Foot Ankle Injuries
Interventions
NeoPatch
Other
Lead sponsor
CryoLife, Inc.
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sycamore, Illinois
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Phase 3 Interventional

Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury

NCT00765700
View directory record Official record
Conditions
Sprain, Strain, Acute Soft Tissue Injury
Interventions
Topical Ketoprofen 10% Cream, Topical Placebo Cream
Drug
Lead sponsor
Imprimis Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2013 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery

NCT01986751
View directory record Official record
Conditions
Pain
Interventions
Clonidine, ropivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jul 21, 2026, 7:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Platelet Rich Plasma for Musculoskeletal Conditions

NCT07231471
View directory record Official record
Conditions
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder, Osteoarthritis Ankle, Elbow Osteoarthritis, Epicondylitis of the Elbow, Plantar Fasciitis of Both Feet, Tendinopathy
Interventions
Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
Biological · Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2035
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Tranexamic Acid in Foot and Ankle Surgeries

NCT03653429
View directory record Official record
Conditions
Foot and Ankle Surgeries, Bunion
Interventions
Tranexamic Acid, Normal saline
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Jul 21, 2026, 7:28 PM EDT
Completed Not applicable Interventional Results available

Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT06818708
View directory record Official record
Conditions
Rotator Cuff Injuries, Shoulder Disease, Hallux Valgus, Ankle Arthropathy
Interventions
Experimental Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Recruiting Phase 2 Interventional

Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients

NCT06780202
View directory record Official record
Conditions
Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury
Interventions
medrol dosepak, HYDROcodone Oral Tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 95 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Atlanta, Georgia • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jul 21, 2026, 7:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery

NCT01550094
View directory record Official record
Conditions
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot, Complete Tear, Ankle and/or Foot Ligament, Pathological Fracture - Ankle and/or Foot, Loose Body in Joint of Ankle and/or Foot
Interventions
Not listed
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Jul 21, 2026, 7:28 PM EDT
Recruiting Not applicable Interventional

The Effects of AFO Heel Height and Stiffness on Gait

NCT04800484
View directory record Official record
Conditions
Musculoskeletal Injury, Musculoskeletal Diseases, Peripheral Nervous System Diseases
Interventions
Tall Soft, Tall Firm, Short Soft, Short Firm
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Even-Up to Minimize Secondary Site Pain For Ankle Fracture

NCT04164563
View directory record Official record
Conditions
Arthralgia, Trouble Balancing
Interventions
Even-Up
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Jul 21, 2026, 7:28 PM EDT
Terminated No phase listed Observational

The Diagnostic Accuracy of the Clinical Examination

NCT03850470
View directory record Official record
Conditions
Musculoskeletal Pain, Musculoskeletal Injury
Interventions
clinical examination, MRI
Diagnostic Test · Other
Lead sponsor
High Point University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Jul 21, 2026, 7:28 PM EDT