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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anxiolysis Clear all
Completed Not applicable Interventional Results available

Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery

NCT00578214
View directory record Official record
Conditions
Basal Cell Carcinoma, Squamous Cell Carcinoma, Skin Cancer, Anxiety
Interventions
Randomized Midazolam, Placebo, Local Anesthesia, Prospective Midazolam
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 8, 2012 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Dose-Finding Study of Intranasal Midazolam for Procedural Sedation in Children

NCT04586504
View directory record Official record
Conditions
Procedural Anxiety
Interventions
Intranasal midazolam
Drug
Lead sponsor
Columbia University
Other
Eligibility
6 Months to 7 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Triazolam and Midazolam for Anxiolysis During Dental Treatment in the Pediatric Patient

NCT03360123
View directory record Official record
Conditions
Dental Anxiety
Interventions
Midazolam Hydrochloride 2Mg/mL Syrup, Triazolam 0.125 MG
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
7 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 21, 2026, 5:02 AM EDT
Not yet recruiting Phase 4 Interventional

Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial

NCT07651956
View directory record Official record
Conditions
Pregnant People, Anxiety
Interventions
Remimazolam, Dexmedetomidine
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Phase 4 Interventional Results available

Intranasal Dexmedetomidine vs Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair

NCT02168439
View directory record Official record
Conditions
Laceration, Anxiety
Interventions
Dexmedetomidine, Midazolam
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
1 Year to 5 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Jul 21, 2026, 5:02 AM EDT
Completed No phase listed Observational

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

NCT01431326
View directory record Official record
Conditions
Adenovirus, Anesthesia, Anxiety, Anxiolysis, Autism, Autistic Disorder, Bacterial Meningitis, Bacterial Septicemia, Benzodiazepine, Bipolar Disorder, Bone and Joint Infections, Central Nervous System Infections, Convulsions, Cytomegalovirus Retinitis, Early-onset Schizophrenia Spectrum Disorders, Epilepsy, General Anesthesia, Gynecologic Infections, Herpes Simplex Virus, Infantile Hemangioma, Infection, Inflammation, Inflammatory Conditions, Intra-abdominal Infections, Lower Respiratory Tract Infections, Migraines, Pain, Pneumonia, Schizophrenia, Sedation, Seizures, Skeletal Muscle Spasms, Skin and Skin-structure Infections, Treatment-resistant Schizophrenia, Urinary Tract Infections, Withdrawal, Sepsis, Gram-negative Infection, Bradycardia, Cardiac Arrest, Cardiac Arrhythmia, Staphylococcal Infections, Nosocomial Pneumonia, Neuromuscular Blockade, Methicillin Resistant Staphylococcus Aureus, Endocarditis, Neutropenia, Headache, Fibrinolytic Bleeding, Pulmonary Arterial Hypertension, CMV Retinitis, Hypertension, Chronic Kidney Diseases, Hyperaldosteronism, Hypokalemia, Heart Failure, Hemophilia, Heavy Menstrual Bleeding, Insomnia
Interventions
The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Drug
Lead sponsor
Daniel Benjamin
Other
Eligibility
Up to 21 Years
Enrollment
3,520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
43
States / cities
Anchorage, Alaska • Little Rock, Arkansas • La Jolla, California + 37 more
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality for Anxiolysis During Laceration Repair in the Pediatric Emergency Room

NCT03475901
View directory record Official record
Conditions
Procedural Anxiety, Laceration of Skin
Interventions
Virtual Reality App
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
5 Years to 13 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2019 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effective of Immersive Virtual Reality Distraction on Memory: Study 1

NCT07172230
View directory record Official record
Conditions
Healthy Participants
Interventions
Immersive Virtual Reality, No distraction Control condition
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Results available

Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults

NCT02410707
View directory record Official record
Conditions
Joint Dislocation, Perianal Abscess, Abscess
Interventions
Nitrous Oxide arm, Propofol, Oxygen
Drug
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 7, 2020 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Immersive VR Distraction on Memory: Study 2

NCT07183839
View directory record Official record
Conditions
Virtual Reality Amnesia
Interventions
Immersive Virtual Reality, Plausible control condition
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 21, 2026, 5:02 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED

NCT05934669
View directory record Official record
Conditions
Laceration of Skin, Anxiety, Discharge Time
Interventions
Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
1 Year to 5 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Lazanda Fentanyl Nasal Spray Pre Radiofrequency Nerve Ablations(RFA) of Lumbar Facet Joints

NCT02571634
View directory record Official record
Conditions
Minor Procedural Pain
Interventions
Lazanda
Drug
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional

Pain Procedures and Anxiolysis Via Distraction With Virtual Reality

NCT04437173
View directory record Official record
Conditions
Virtual Reality, Anxiety, Pain
Interventions
Virtual Reality Headset Distraction
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of DEX-IN During Outpatient Procedures

NCT03348423
View directory record Official record
Conditions
Pain
Interventions
DEX-IN, Fentanyl, Placebo
Drug
Lead sponsor
Baudax Bio
Industry
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Patient-Controlled Anxiolysis With Dexmedetomidine (PCA-DEX) for Burn-care Dressing Changes

NCT02409810
View directory record Official record
Conditions
Anxiety, Burns
Interventions
Dexmedetomidine
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 89 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Jul 21, 2026, 5:02 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Aromatherapy With Lavender as Anxiolysis Prior to Cataracts Surgery

NCT05708066
View directory record Official record
Conditions
Aromatherapy, Anxiety
Interventions
Lavender Aromatherapy, Non-scented Tab
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Jul 21, 2026, 5:02 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions

NCT01011634
View directory record Official record
Conditions
Undesired Intrauterine Pregnancy, First Trimester Pregnancy
Interventions
Intravenous moderate sedation versus oral medication
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
16 Years to 55 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 15, 2013 · Synced Jul 21, 2026, 5:02 AM EDT
Terminated Phase 4 Interventional

Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients

NCT03043430
View directory record Official record
Conditions
Anxiety, Pediatric ALL, Procedural Anxiety
Interventions
Ketamine 100 MG/ML, Midazolam 5 MG/ML
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
2 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Jul 21, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gurney Journey: Virtual Reality Distraction

NCT06283108
View directory record Official record
Conditions
Dental Caries in Children, Dental Diseases, Gastrointestinal Surgery, Procedures Requiring Anesthesia
Interventions
Standard Child Life Preparation and Support + Meta Quest 2 VR headset with Gurney Journey (a mixed reality experience), Standard Child Life Preparation and Support
Device · Behavioral
Lead sponsor
Children's Hospital Colorado
Other
Eligibility
5 Years to 17 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Jul 21, 2026, 5:02 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Virtual Reality as Distraction Analgesia and Anxiolysis for Pediatric Otolaryngology Procedures

NCT06245395
View directory record Official record
Conditions
Virtual Reality, Otolaryngology
Interventions
Virtual Reality
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
7 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Jul 21, 2026, 5:02 AM EDT