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ClinicalTrials.gov public records Last synced May 21, 2026, 9:05 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Apical Periodontitis Clear all
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst, Apical Granuloma, Periradicular Disease, Previous Endodontic Treatment
Interventions
PBM treatment, PBM sham treatment, EMS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced May 21, 2026, 9:05 PM EDT
Not yet recruiting Phase 4 Interventional
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Platelet rich fibrin
Biological
Lead sponsor
Mark Schachman
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced May 21, 2026, 9:05 PM EDT
Not yet recruiting Phase 4 Interventional
View directory record Official record
Conditions
Apical Periodontitis, Endodontic Disease, Root Canal Infection
Interventions
Nanozyme treatment, Control (Standard treatment)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced May 21, 2026, 9:05 PM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Apical Periodontitis
Interventions
GentleWave System
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 99 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Foundation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
Interventions
Irrisafe ip, GentleWave System, Waterlase iPlus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
14 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced May 21, 2026, 9:05 PM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative, Suppuration of Gingival Crevice
Interventions
Scaling and Root Planing, Diode Laser + Scaling and Root Planing
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced May 21, 2026, 9:05 PM EDT
Terminated Phase 2 Interventional Results available
View directory record Official record
Conditions
Caries,Dental, Apical Periodontitis
Interventions
Kovanaze Nasal Spray, Articaine Injection
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
6 Years to 18 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Endodontic Infection, Periapical Periodontitis
Interventions
Calcium Hydroxide (CH), control group
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Interventions
Multisonic vs Sonic activation of irrigants
Device
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Postoperative Pain
Interventions
PBM Therapy, PBM Sham
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced May 21, 2026, 9:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Chronic Apical Periodontitis of Pulpal Origin
Interventions
Endodontic procedure with varied apical preparation size
Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2012 · Synced May 21, 2026, 9:05 PM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
Apical Periodontitis
Interventions
GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced May 21, 2026, 9:05 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Apical Periodontitis, Pulp Disease, Dental
Interventions
Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl, supplementary irrigation
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced May 21, 2026, 9:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Dental Pulp Necrosis, Periapical Periodontitis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced May 21, 2026, 9:05 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Chronic Apical Periodontitis of Pulpal Origin
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced May 21, 2026, 9:05 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Leukocyte and Platelet Rich Fibrin
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced May 21, 2026, 9:05 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Chlorhexidine, Calcium Hydroxide
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced May 21, 2026, 9:05 PM EDT