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Showing 1–24 of 183 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Astigmatism Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dispensing Evaluation of Investigational Contact Lenses

NCT02625220
View directory record Official record
Conditions
Myopia; Astigmatism
Interventions
Prototype toric lens senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
12
States / cities
Jacksonville, Florida • Pembroke Pines, Florida • Winter Park, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2017 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation Study on Corneal Lens for Vision Correction

NCT02053688
View directory record Official record
Conditions
Astigmatism
Interventions
Astigmatic Correction Lens (Nexis ACCL lenses), Toric Soft Contact Lenses
Device
Lead sponsor
FORSIGHT Vision3
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
6
States / cities
Fremont, California • Livermore, California • Menlo Park, California + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Sep 5, 2026, 1:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism

NCT04698590
View directory record Official record
Conditions
Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront, Wavefront Aberration, Corneal, Pellucid Marginal Corneal Degeneration, Keratoglobus
Interventions
Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
Device
Lead sponsor
Cornea and Laser Eye Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Teaneck, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Results available

Clinical Investigation of the WaveLight® EX500 Excimer Laser

NCT04805593
View directory record Official record
Conditions
Hyperopia, Hyperopic Astigmatism
Interventions
WaveLight EX500 excimer laser system, LASIK
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Overland Park, Kansas • Kansas City, Missouri • Greensboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 5, 2026, 1:26 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Multi Laser Platform Comparison Study for LASIK

NCT00770094
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Excimer Lasers, Excimer Laser for the LASIK procedure, Excimer Laser for LASIK
Device
Lead sponsor
Durrie Vision
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Atlanta, Georgia • Edina, Minnesota • McLean, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 5, 2009 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Apioc Contact Lens Feasibility

NCT03688672
View directory record Official record
Conditions
Ametropia, Myopia, Hyperopia, Astigmatism, Presbyopia
Interventions
Apioc Contact Lens Design
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Clinical Performance Evaluation of Two Daily Disposable Silicone Hydrogel Toric Contact Lenses

NCT04254003
View directory record Official record
Conditions
Refractive Errors
Interventions
DT1 Toric contact lenses, AO1DfA contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
Maitland, Florida • Eden Prairie, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Phase 4 Interventional Results available

Low Cylinder Toric

NCT00732030
View directory record Official record
Conditions
Cataracts
Interventions
Toric IOL (SN60T3)
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2010 · Synced Sep 5, 2026, 1:26 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Comparison of Contoura Vision Outcomes Programmed Using the Manifest Refraction Verses Using Phorcides Planning Software in Patients With Oblique Astigmatism

NCT05888337
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Contoura LASIK with Phorcides planning strategy, Contoura LASIK with manifest refraction planning strategy
Device
Lead sponsor
Bismarck Lasik
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Bismarck, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Results available

Clinical Investigation of the Safety and Effectiveness of an Investigational Model of the TECNIS® Intraocular Lens

NCT03949335
View directory record Official record
Conditions
Cataract, Corneal Astigmatism
Interventions
IOL Model ZFR00V, IOL Model ZCB00
Device
Lead sponsor
Johnson & Johnson Surgical Vision, Inc.
Industry
Eligibility
22 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
15
States / cities
Bakersfield, California • Torrance, California • West Palm Beach, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Corneal Refractive Therapy Design Comparison for -4 to -6 Diopter Treatment for Overnight Wear for Myopia

NCT05438615
View directory record Official record
Conditions
Myopia
Interventions
Corneal Refractive Therapy-spherical, Corneal Refractive Therapy-aspherical
Other
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Results available

Multicenter Clinical Trial of a Phakic Implantable Collamer® Lens (ICL)

NCT04283149
View directory record Official record
Conditions
Myopia, Myopic Astigmatism
Interventions
EVO/EVO+ Visian ICL
Device
Lead sponsor
Staar Surgical Company
Industry
Eligibility
21 Years to 45 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
14
States / cities
Phoenix, Arizona • Honolulu, Hawaii • Indianapolis, Indiana + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Investigation of the Vision-R800 Device.

NCT04208750
View directory record Official record
Conditions
Myopia, Hyperopia, Astigmatism, Presbyopia
Interventions
Vision R-800 Phoropter, Standard Phoropter
Device
Lead sponsor
Pete Kollbaum, OD, PhD
Other
Eligibility
18 Years to 70 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 5, 2026, 1:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear Day

NCT07303920
View directory record Official record
Conditions
Astigmatism
Interventions
Daily disposable contact lenses for astigmatism
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 5, 2026, 1:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

SMILE (Small Incision Lenticule Extraction) in the DoD (Department of Defense)

NCT04072289
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Visumax spherocylindrical treatment
Device
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
22 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Femtosecond Laser-assisted Arcuate Incisions Versus Manual Arcuate Incisions Outcomes

NCT04126174
View directory record Official record
Conditions
Cataract
Interventions
femtosecond laser system arcuate corneal incision, Manual LRI
Device · Other
Lead sponsor
Gainesville Eye Associates
Other
Eligibility
40 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 5, 2026, 1:26 AM EDT
Terminated No phase listed Observational

DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study

NCT06483113
View directory record Official record
Conditions
Myopia, Hyperopia, Presbyopia, Astigmatism
Interventions
Delefilcon A spherical soft contact lenses, Delefilcon A toric soft contact lenses, Delefilcon A multifocal soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
7 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
San Diego, California • Ponte Vedra Beach, Florida • West Palm Beach, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 5, 2026, 1:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Assessment of Visual Performance in Patients With Low Levels of Astigmatism

NCT00842231
View directory record Official record
Conditions
Cataract Extraction, Corneal Astigmatism
Interventions
Visual performance measures
Other
Lead sponsor
Alcon Research
Industry
Eligibility
50 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2010 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia

NCT00762281
View directory record Official record
Conditions
Hyperopia
Interventions
MEL 80 Hyperopic LASIK Treatment
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
21 Years and older
Enrollment
189 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
6
States / cities
San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2012 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Wear Experience With Daily Disposable and Monthly Replacement Toric Contact Lenses

NCT05580575
View directory record Official record
Conditions
Astigmatism Bilateral
Interventions
Daily disposable toric soft contact lens, Monthly replacement toric daily wear soft contact lens
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
3
States / cities
Medina, Minnesota • Columbus, Ohio • Granville, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Sep 5, 2026, 1:26 AM EDT
Active, not recruiting Not applicable Interventional

Acuity 200™ (Fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear

NCT06009458
View directory record Official record
Conditions
Myopia
Interventions
Acuity 200™ (fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear
Device
Lead sponsor
Acuity Polymers, Inc.
Industry
Eligibility
7 Years and older
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
9
States / cities
Mission Viejo, California • Oakland, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 5, 2026, 1:26 AM EDT
Completed No phase listed Observational

Evaluation of Visual Acuity of the Envista One-piece Acrylic Toric IOL MX60ET

NCT05739656
View directory record Official record
Conditions
Astigmatism
Interventions
CATARACT SURGERY
Procedure
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 5, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Prospective Evaluation of Contrast Sensitivity and Disability Glare in Refractive Surgery, a Sub-Study of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)

NCT00413868
View directory record Official record
Conditions
Myopia
Interventions
LASIK, PRK, Small target contrast sensitivity and disability glare
Procedure · Behavioral
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2008 · Synced Sep 5, 2026, 1:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Refractive Accuracy of "2WIN" and Portable Autorefractors

NCT04249505
View directory record Official record
Conditions
Refractive Error - Myopia Axial, Astigmatism, Accomodation, Visual Impairment, Hyperopia of Both Eyes
Interventions
"2WIN" Photoscreener, "Plusoptix A12", "Retinomax"
Device
Lead sponsor
Alaska Blind Child Discovery
Other
Eligibility
6 Months to 95 Years
Enrollment
708 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 5, 2026, 1:26 AM EDT