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Showing 1–24 of 38 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Biofilm Infection Clear all
Completed Not applicable Interventional

Activated Carbon Interphase Effect on Biofilm and Total Bacterial Load

NCT03461783
View directory record Official record
Conditions
Wound Infection
Interventions
Zorflex Activated Carbon Dressing, Standard of Care
Device
Lead sponsor
Brock Liden, DPM
Individual
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Circleville, Ohio • Logan, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 1 Interventional

E. Coli for Prevention of Catheter UTI in SCI Patients

NCT00458471
View directory record Official record
Conditions
Urinary Tract Infection(UTI)
Interventions
Insertion of a urinary catheter coated with benign E. coli
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2007 · Synced Sep 9, 2026, 12:31 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth

NCT00098267
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
3 Months and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 1 Interventional Results available

Bacterial Interference for Prevention of Catheter-Associated UTI: Geriatric Pilot Study

NCT00554996
View directory record Official record
Conditions
Urinary Tract Infection
Interventions
E. coli 83972 coated urinary catheter
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2015 · Synced Sep 9, 2026, 12:31 AM EDT
Completed No phase listed Observational

Comparison of Infection Rates Among Patients Using Two Catheter Access Devices

NCT00965198
View directory record Official record
Conditions
Catheter-Related Infections, Bacteremia
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2013 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Not applicable Interventional Results available

Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm

NCT02294175
View directory record Official record
Conditions
Lower Extremity or Diabetic Foot Ulcers, Bacterial Infection
Interventions
Larval Debridement Therapy, Bedside Sharp Debridement
Device · Procedure
Lead sponsor
North Florida Foundation for Research and Education
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Sep 9, 2026, 12:31 AM EDT
Completed No phase listed Observational

A Clinical and Imaging Study to Evaluate a Novel Dentifrice

NCT02271815
View directory record Official record
Conditions
Gingivitis, Periodontitis, Dental Plaque
Interventions
Oral Hygiene
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 9, 2026, 12:31 AM EDT
Active, not recruiting Phase 2 Interventional

Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection

NCT06621251
View directory record Official record
Conditions
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Interventions
TRL1068 (calpurbatug), a human monoclonal antibody, DAIR
Drug · Procedure
Lead sponsor
Trellis Bioscience LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
11
States / cities
Gilbert, Arizona • Los Angeles, California • Jacksonville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 4 Interventional

Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds

NCT03686904
View directory record Official record
Conditions
Wound Infection
Interventions
Benzalkonium Gel, standard of care topical gel, Debridement, benzalkonium irrigation, Saline Irrigation (SOC Irrigation)
Drug · Other · Procedure
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 99 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2022 · Synced Sep 9, 2026, 12:31 AM EDT
Withdrawn No phase listed Observational

Non-Invasive Oral Biofilm Characterization

NCT02178046
View directory record Official record
Conditions
Gingivitis
Interventions
optical measurements
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation

NCT03721328
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
vancomycin hydrochloride and tobramycin sulfate
Combination Product
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Saginaw, Michigan • Charlotte, North Carolina • Oklahoma City, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 9, 2026, 12:31 AM EDT
Enrolling by invitation Phase 4 Interventional

Nanozymes in Endodontics

NCT07518901
View directory record Official record
Conditions
Apical Periodontitis, Endodontic Disease, Root Canal Infection
Interventions
Nanozyme treatment, Control (Standard treatment)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Xylitol for Chronic Sinusitis

NCT03229551
View directory record Official record
Conditions
Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus, Endoscopic Sinus Surgery, Biofilms, Bacterial Overgrowth
Interventions
Xylitol, Saline
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Not applicable Interventional Results available

V.A.C. VeraFlo™ Instillation Therapy vs V.A.C. Ulta™ Therapy on Biofilm in Chronically Infected Wounds

NCT02009501
View directory record Official record
Conditions
Lower Extremity Wound Infected, Venous Stasis Ulcers
Interventions
VAC VeraFlo with Dakins Instillation, VAC Ulta Therapy
Device
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Not applicable Interventional

Electroceutical Dressing Technology (EDT) Against Wound Microbial Biofilm Infection

NCT04794621
View directory record Official record
Conditions
Wound Heal
Interventions
Electroceutical Dressing Technology-EDThi, Adding EDTlo (Procellera®) for 3 weeks after use of EDThi
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 2 Interventional

A Second Trial of the Abbreviated Protocol Two-Stage Exchange

NCT05607030
View directory record Official record
Conditions
Prosthetic-joint Infection
Interventions
VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics, Experimental Antibiotics
Combination Product · Procedure · Drug
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
22 Years to 84 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
19
States / cities
Phoenix, Arizona • Los Angeles, California • Sarasota, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Sep 9, 2026, 12:31 AM EDT
Recruiting No phase listed Observational

OCT in Open Fracture and Infected Fracture

NCT05785182
View directory record Official record
Conditions
Trauma Injury, Trauma, Open Fracture, Fracture Infection
Interventions
Open Fracture, Infected Fracture
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 9, 2026, 12:31 AM EDT
Completed No phase listed Observational Results available

MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants

NCT03132246
View directory record Official record
Conditions
Open Reduction and Internal Fixation of Extremity Fractures
Interventions
Blood draws
Diagnostic Test
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Sep 9, 2026, 12:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

NCT05959629
View directory record Official record
Conditions
Endodontic Disease, Root Canal Infection
Interventions
Waterlase Express™, BIOLASE®, Sodium Hypochlorite
Device · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 9, 2026, 12:31 AM EDT
Completed No phase listed Observational

Catheter Biofilm Microbiome in Infected Neonatal Catheters.

NCT01985737
View directory record Official record
Conditions
Catheter-associated Bloodstream Infections (CLABSI)
Interventions
Sample collection
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
1 Day to 3 Weeks
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 2 Interventional Results available

Abbreviated Protocol for Two-Stage Exchange

NCT04662632
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty, VT-X7 Treatment System with Vancomycin Hydrochloride
Combination Product · Drug · Procedure
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
22 Years to 84 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
17
States / cities
Phoenix, Arizona • Torrance, California • Washington D.C., District of Columbia + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 9, 2026, 12:31 AM EDT
Recruiting No phase listed Observational

Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence

NCT05172089
View directory record Official record
Conditions
Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL), Diabetic Foot, Diabetic Foot Infection
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Tucson, Arizona • Cranberry Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 9, 2026, 12:31 AM EDT
Completed Phase 1 Interventional Results available

Colonizing Neurogenic Bladders With Benign Flora

NCT00371631
View directory record Official record
Conditions
Spinal Cord Injury, Urinary Tract Infection
Interventions
Insertion of urinary catheters coated with E. coli 83972
Biological
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 23, 2014 · Synced Sep 9, 2026, 12:31 AM EDT
Withdrawn Not applicable Interventional

Biofilm Infection in Adults and Children Burn Injury

NCT03248154
View directory record Official record
Conditions
Thermal Burn, Wound
Interventions
Procellera
Device
Lead sponsor
Gayle Gordillo
Other
Eligibility
2 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
4
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Sep 9, 2026, 12:31 AM EDT