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Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Bone Strength Clear all
Completed No phase listed Observational Accepts healthy volunteers

Bone Geometry, Strength, and Biomechanical Changes in Runners With a History of Stress Fractures

NCT00766077
View directory record Official record
Conditions
Stress Fractures, Bone Geometry, Bone Strength, Biomechanical Changes
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 35 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 13, 2010 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Effects of Physical Training on Bone and Muscle Quality, Muscle Strength, and Motor Coordination in Children With NF1

NCT01058330
View directory record Official record
Conditions
Neurofibromatosis Type 1
Interventions
Plyometric training program
Other
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
4 Years to 19 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Sep 6, 2026, 2:26 AM EDT
Recruiting Phase 2 Interventional

Role of Estrogen on Skeletal Outcomes in FHA

NCT07010146
View directory record Official record
Conditions
Bone Strength, Bone Density, FHA (Functional Hypothalamic Amenorrhea)
Interventions
transdermal 17β-E2 with cyclic progestin, oral 17β-E2 with cyclic progestin, transdermal EE+LNG
Drug
Lead sponsor
University of Virginia
Other
Eligibility
14 Years to 30 Years · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

MACS and Healthy Volunteers Bone Study

NCT04343560
View directory record Official record
Conditions
MACS Syndrome
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
380 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 26, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Vitamin D Supplementation on Strength, Bone Density, and Injury Risk in Collegiate Athletes

NCT03151174
View directory record Official record
Conditions
Vitamin D Deficiency
Interventions
Vitamin D 10000 UNT, Vitamin D 5000 UNT
Drug
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 30 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 6, 2026, 2:26 AM EDT
Not yet recruiting Phase 4 Interventional

Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1

NCT07554417
View directory record Official record
Conditions
GLP - 1, Obesity & Overweight, Muscle Loss, Exercise Intervention, Dietary Assessment
Interventions
Semaglutide, Dietary Counseling, Exercise
Drug · Behavioral
Lead sponsor
William Marsh Rice University
Other
Eligibility
40 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

The Effect of Patellar Eversion on Functional Outcomes in Primary Total Knee Arthroplasty

NCT01777009
View directory record Official record
Conditions
Total Knee Replacement, Arthroplasty, Patella
Interventions
Primary Total Knee Replacement Surgery
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2013 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Sharing Our Strength: A Research Study for Bone Marrow/Stem Cell Transplant Survivors

NCT00701844
View directory record Official record
Conditions
Leukemia, Acute Leukemia, Acute Lymphocytic Leukemia, Multiple Myeloma, Hematological Cancers, Psychological Distress
Interventions
Writing A (Experimental informative writing), Writing B (Experimental noninformative writing), Writing C (Control informative writing), Writing D (Control noninformative writing)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Hackensack, New Jersey • New York, New York • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 16, 2017 · Synced Sep 6, 2026, 2:26 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Impact of Glomerular Disorders on Bone Quality and Strength

NCT04528446
View directory record Official record
Conditions
Glomerular Disease, Bone Diseases, Metabolic, Bone Fracture
Interventions
Dual-energy X-ray absorptiometry, High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT), Blood draw and Urine collection, Questionnaires
Radiation · Other
Lead sponsor
Columbia University
Other
Eligibility
5 Years to 55 Years
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
2
States / cities
New York, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Sep 6, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Skeletal Fragility in Type 1 Diabetes: Glycemic Control and Bone Strength

NCT04289727
View directory record Official record
Conditions
Type1diabetes
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
8 Years to 14 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of DHEA/Exercise on Bone, Muscle and Balance

NCT00664053
View directory record Official record
Conditions
Osteoporosis, Frailty
Interventions
DHEA, Yoga, Placebo, Aerobics
Dietary Supplement · Behavioral
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
65 Years and older · Female only
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 28, 2008 · Synced Sep 6, 2026, 2:26 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Bone in CKD Alkali Response (BICARb Pilot Trial)

NCT05918029
View directory record Official record
Conditions
Chronic Kidney Diseases, Bone Loss
Interventions
Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution
Drug · Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
5 Years to 100 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
The Bronx, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Advanced Glycation Endproducts and Bone Material Strength in T2D Treated With Pyridoxamine

NCT03778580
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Pyridoxamine Dihydrochloride, placebo
Dietary Supplement · Drug
Lead sponsor
Columbia University
Other
Eligibility
65 Years and older · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of the RSVP Bone Builders Program on Strength, Balance, Fall Risk and Life Satisfaction

NCT02762305
View directory record Official record
Conditions
Exercise
Interventions
RSVP Bone Builders Group Exercise
Other
Lead sponsor
California State University, Northridge
Other
Eligibility
60 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 2 Interventional Results available

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

NCT02325414
View directory record Official record
Conditions
Spinal Cord Injury, Acute Spinal Cord Injury, Bone Loss, Osteoporosis
Interventions
Zoledronic acid, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Vibration Intervention For Bone Enhancement In Childhood Cancer Survivors

NCT01010230
View directory record Official record
Conditions
Bone Mineral Density, Bone Strength
Interventions
LMHF mechanical stimulation active device, LMHF mechanical stimulation placebo device
Device
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
7 Years to 17 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Sep 6, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Effects of Exemestane on Bone Strength

NCT01144468
View directory record Official record
Conditions
Osteoporosis, Breast Cancer
Interventions
Not listed
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older · Female only
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2022
U.S. locations
2
States / cities
Sacramento, California • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Exercise and Body Composition in Juvenile Idiopathic Arthritis

NCT02479373
View directory record Official record
Conditions
Arthritis, Juvenile
Interventions
Ren-Ex Machine, Dual-Emission X-ray Absorptiometry (DEXA) scan, Biodex dynamometer, Sub-maximal test, Quality of life questionnaires
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
10 Years to 21 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 6, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating Study

NCT03758651
View directory record Official record
Conditions
Williams Syndrome, Lipedema
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional

The Effect of Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation on Bone Strength.

NCT07325149
View directory record Official record
Conditions
Secondary Osteoporosis, Sarcopenia
Interventions
Exoskeleton-Assisted Walking (EAW) + active Transcutaneous Spinal Cord Stimulation (tSCS), Exoskeleton-assisted walking (EAW) + sham Transcutaneous Spinal Cord Stimulation (tSCS)
Device
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
21 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Feasibility of At-Home Chair-Based Resistance Band Training to Improve Balance, Strength, and Bone Density in Older Adults

NCT06671847
View directory record Official record
Conditions
Sarcopenic Obesity
Interventions
THERABand resistance exercise bands
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
50 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.

NCT00104572
View directory record Official record
Conditions
Hypogonadism, Diabetes, Sarcopenia, Osteoporosis, Depression
Interventions
Androgel (Testosterone Gel), Anastrozole (Aromatase Inhibitor), Placebo tablet, Placebo gel, Calcium Cardone 500mg with vitamin D 400 IU
Drug · Dietary Supplement
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
65 Years and older · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 4 Interventional Results available

Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta

NCT00131469
View directory record Official record
Conditions
Osteogenesis Imperfecta
Interventions
Teriparatide (FORTEO), Placebos
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 85 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
3
States / cities
Baltimore, Maryland • Portland, Oregon • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Sep 6, 2026, 2:26 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

NCT05701254
View directory record Official record
Conditions
Type 1 Diabetes, Osteopenia, Bone Loss, Fractures, Bone
Interventions
Transilial bone biopsy
Procedure
Lead sponsor
Creighton University
Other
Eligibility
50 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Sep 6, 2026, 2:26 AM EDT