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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:06 AM EDT

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Showing 1–24 of 80 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Borderline Personality Disorder Clear all
Completed Phase 3 Interventional

Efficacy and Safety of Olanzapine in Patients With Borderline Personality Disorder

NCT00088036
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Olanzapine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
7
States / cities
National City, California • New Haven, Connecticut • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2006 · Synced Oct 20, 2026, 11:06 AM EDT
Terminated Phase 2 Interventional Results available

Preliminary Trial of the Effect of Glucocorticoid Receptor Antagonist on Borderline Personality Disorder (BPD)

NCT01212588
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
mifepristone, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 64 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Oct 20, 2026, 11:06 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Role Of Sensitivity to neuroEndocrine Systems in Social Decisions

NCT06018727
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Hydrocortisone, Yohimbine, Placebo
Drug · Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Active, not recruiting Phase 2 Interventional

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

NCT06446765
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
mindfulness-based Neurofeedback, control Neurofeedback
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 20, 2026, 11:06 AM EDT
Terminated Phase 2 Interventional Results available

Ketamine in Borderline Personality Disorder

NCT03395314
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 60 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Oct 20, 2026, 11:06 AM EDT
Terminated Phase 2 Interventional Results available

N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD

NCT00539188
View directory record Official record
Conditions
Borderline Personality Disorder, Self-Injurious Behavior
Interventions
N-Acetylcysteine, placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Phase 4 Interventional Results available

Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder

NCT00533117
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Fluoxetine, Dialectical Behavior Therapy, Supportive psychotherapy
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

Preschooler Emotion Regulation in the Context of Maternal Borderline Personality Disorder

NCT03060902
View directory record Official record
Conditions
Borderline Personality Disorder, Emotional Problem
Interventions
Dialectical Behavior Therapy Skills
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Active, not recruiting Not applicable Interventional

PILOT Phase: BPD Study

NCT07223619
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 20, 2026, 11:06 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

NCT06045650
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
baseline serum oxytocin levels, Emotional Sensitivity test, Neuro-economical game, Childhood Trauma Questionnaire, Relationships Questionnaire, demographic questionnaire
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Event Related Potentials in Borderline Personality Disorder and Major Depression

NCT01469663
View directory record Official record
Conditions
Borderline Personality Disorder, Major Depression
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
2
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Dialectical Behavior Therapy Rutgers University Research Program

NCT03123198
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical Behavior Therapy
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2023
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms

NCT01189812
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia, Depression Not Otherwise Specified, Borderline Personality Disorder
Interventions
Lithium Carbonate, Placebo, Citalopram
Drug
Lead sponsor
Columbia Northwest Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
San Diego, California • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Aug 24, 2011 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Phase 2 Interventional Results available

Study to Test the Efficacy and Safety of Vafidemstat in Adult Borderline Personality Disorder Population

NCT04932291
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
vafidemstat, Placebo
Drug
Lead sponsor
Oryzon Genomics S.A.
Industry
Eligibility
18 Years to 65 Years
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
11
States / cities
Oceanside, California • Hialeah, Florida • Miami, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Dialectical Behavior Therapy for Adolescents at Rutgers University

NCT03861858
View directory record Official record
Conditions
Borderline Personality Disorder in Adolescence
Interventions
DBT-A
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
13 Years to 20 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

Cognitive Reappraisal Training for Borderline Personality

NCT04967222
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Cognitive Reappraisal by Distancing, Control Downregulate Condition
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Central Meditation and Imagery Therapy for Augmentation of Borderline Personality Disorder Treatment

NCT02125942
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Central Meditation and Imagery Therapy
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personality Change Study for Borderline Personality Disorder

NCT06005129
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Personality-Based Therapy
Behavioral
Lead sponsor
Shannon E. Sauer-Zavala
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 20, 2026, 11:06 AM EDT
Completed No phase listed Observational

Tracking Response in Advance of Investigational Trials, Borderline Study

NCT05025670
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Supportive psychotherapy
Behavioral
Lead sponsor
Adams Clinical
Network
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Oct 20, 2026, 11:06 AM EDT
Not listed Not applicable Interventional

DBT in Borderline Personality Disorder

NCT00252031
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical Behavioral Therapy
Behavioral
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2005 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

Mapping Aspects of Psychotherapy in Dialectical Behavior Therapy

NCT04626310
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical behavior therapy - emotion regulation skills training, Dialectical behavior therapy - interpersonal effectiveness skills training, Interpersonal psychotherapy
Behavioral
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
18 Years to 60 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder

NCT00145678
View directory record Official record
Conditions
Borderline Personality Disorder, Alcohol Use Disorder
Interventions
Psychodynamic Therapy, Optimized Community Care
Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2015 · Synced Oct 20, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Evaluation of DBT Compared to Drug Counseling for Opiate Addicts

NCT00117741
View directory record Official record
Conditions
Opiate Addiction, Borderline Personality Disorder
Interventions
Dialectical Behavior Therapy, Drug Counseling
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 2, 2012 · Synced Oct 20, 2026, 11:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

STAIR for Trauma and Emotion Dysregulation

NCT05397613
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Borderline Personality Disorder, Emotion Regulation
Interventions
STAIR
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Oct 20, 2026, 11:06 AM EDT