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Showing 1–24 of 113 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Carpal Tunnel Syndrome Clear all
Completed Not applicable Interventional

Ultrasound Guided - Incisionless Threaded Carpal Tunnel Release

NCT04101955
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Incisionless Threaded Carpal Tunnel, Standard Mini-Open Carpal Tunnel
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Not applicable Interventional

Patient Outcomes With Endoscopic Versus Open Carpal Tunnel Release

NCT00880295
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
endoscopic carpal tunnel release, open carpal tunnel release
Procedure
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Jul 22, 2026, 12:56 AM EDT
Not listed Phase 2 Interventional

Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy

NCT01562860
View directory record Official record
Conditions
Median Nerve Compression
Interventions
Pronator Teres Release, dual compression release, median nerve release only
Procedure
Lead sponsor
Christine M. Kleinert Institute for Hand and Microsurgery
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jul 22, 2026, 12:56 AM EDT
Not yet recruiting Not applicable Interventional

Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test

NCT07158892
View directory record Official record
Conditions
Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS), Lateral Epicondylitis, Osteoarthritis, Trigger Digit, Dupuytren Contracture, Rotator Cuff Tendinopathy, De Quervain Disease
Interventions
Diagnostic Advance Care Planning Discussion, Informational Statement Only
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Adding Lidocaine to Corticosteroid Injections Reduce Pain Intensity in Hand Surgery

NCT06188221
View directory record Official record
Conditions
Hand Osteoarthritis, Trigger Finger, Carpal Tunnel Syndrome
Interventions
Lidocaine, Corticoids
Drug
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 2, 2024 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Not applicable Interventional

The Effect of Surgical Incision Size on Carpal Tunnel Surgery

NCT00435071
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Carpal tunnel release surgery
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 17, 2011 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Not applicable Interventional

Evaluation of the MANOS Carpal Tunnel Release System in Patients With Carpal Tunnel Syndrome

NCT01450735
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
MANOS CTR™
Device
Lead sponsor
Thayer Intellectual Property, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
Hayward, California • San Francisco, California • Willits, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Phase 2 Interventional

Sham Device, Pill Placebo or Treatment For Arm Pain

NCT00029497
View directory record Official record
Conditions
Cumulative Trauma Disorders, Repetitive Strain Injury, Carpal Tunnel Syndrome, Pain
Interventions
Acupuncture, Amitriptyline
Procedure · Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2004
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Jul 22, 2026, 12:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain

NCT04060875
View directory record Official record
Conditions
Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction, Complex Regional Pain Syndromes, Phantom Limb Pain, Rheumatoid Arthritis, Carpal Tunnel Syndrome, Repetitive Strain Injury
Interventions
Karuna Labs Virtual Reality Software
Device
Lead sponsor
Karuna Labs Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Not applicable Interventional

Effect of Lumbrical Stretching on Carpal Tunnel Syndrome

NCT00803257
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Lumbrical splint and Lumbrical exercises
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Jul 22, 2026, 12:56 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Wound Closure Study in Carpal Tunnel and Trigger Finger Surgery

NCT03781141
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Trigger Finger
Interventions
Wound closure
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jul 22, 2026, 12:56 AM EDT
Not listed Phase 4 Interventional

A Comparison of Ultrasound-guided Steroid Injection With Wrist Splint in Carpal Tunnel Syndrome

NCT04515966
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Methylprednisolone Injection [Solu-Medrol], wrist splint
Drug · Device
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boardman, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Not applicable Interventional Results available

Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial

NCT01118715
View directory record Official record
Conditions
Post-traumatic Carpal Tunnel Syndrome, Complex Regional Pain Syndrome, Edema
Interventions
Compression glove
Device
Lead sponsor
J&M Shuler
Industry
Eligibility
18 Years to 85 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Phase 4 Interventional Results available

Preoperative Antibiotics for Carpal Tunnel Release Surgery

NCT03432858
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Vancomycin, Cefazolin, Saline Solution
Drug
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated No phase listed Observational

Corticosteroid Injection as a Predictor of Outcome in Carpal Tunnel Release

NCT00655915
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Corticosteroid Injection- 1ml of Betamethasone and 1 ml of 1% Lidocaine
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Jul 22, 2026, 12:56 AM EDT
Not listed Not applicable Interventional

Carpal Tunnel Release With Risk Factors for Amyloidosis

NCT05793320
View directory record Official record
Conditions
Amyloidosis
Interventions
Carpal Tunnel Release Surgery
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
50 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Not applicable Interventional

Comparative Study of Two Incision vs. Mini Open Carpal Tunnel Release

NCT05325567
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Mini open incision CTR
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 17, 2023 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nylon Versus Chromic Gut Sutures for Minor Hand Surgery

NCT03407820
View directory record Official record
Conditions
All Minor Hand Surgery Including, Carpal Tunnel Syndrome, Trigger Finger, Ganglion Cysts, De Quervain Syndrome, Dupuytren Contracture
Interventions
Absorbable Chromic gut sutures, Non-absorbable Nylon sutures
Procedure
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
3
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 22, 2026, 12:56 AM EDT
Completed Phase 4 Interventional

A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions

NCT00904202
View directory record Official record
Conditions
Postherpetic Neuralgia, Diabetic Neuropathy, Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, HIV Neuropathy, Idiopathic Sensory Neuropathy, Peripheral Neuropathy
Interventions
Placebo Capsules + Placebo Patch, Placebo capsules + Lidoderm®, Gabapentin + Placebo, Gabapentin + Lidoderm®, Gabapentin 300 mg capsules 1800 mg/day + placebo patch, Gabapentin 1800 mg/day + Lidoderm patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
7
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Phase 4 Interventional Results available

Post-operative Analgesia in Elective, Soft-tissue Hand Surgery

NCT02029235
View directory record Official record
Conditions
Carpal Tunnel, Ganglion Cyst, Trigger Finger, De Quervain Disease
Interventions
Acetaminophen/Ibuprofen, Acetaminophen/Hydrocodone
Drug
Lead sponsor
Alexander Payatakes, M.D.
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

NeuroPath Comparative Validation Study Plan

NCT00393549
View directory record Official record
Conditions
Carpal Tunnel Syndrome (CTS)
Interventions
NeuroPath
Device
Lead sponsor
Excel-Tech Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
2
States / cities
Dothan, Alabama • St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Jul 22, 2026, 12:56 AM EDT
Terminated Not applicable Interventional Results available

PRP as Adjuvant Treatment to CTR for Severe CTS Tunnel Syndrome

NCT04811287
View directory record Official record
Conditions
Carpal Tunnel Syndrome, PRP
Interventions
Carpal Tunnel Release with Platelet-Rich Plasma, Carpal Tunnel Release without Platelet-Rich Plasma
Device · Procedure
Lead sponsor
Michael Fredericson, MD
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 22, 2026, 12:56 AM EDT
Completed No phase listed Observational

Carpal Tunnel/Amyloidosis Blood Sample Study

NCT02587728
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Amyloidosis
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Jul 22, 2026, 12:56 AM EDT