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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Cervical Spine Degeneration Clear all
Completed No phase listed Observational Results available

Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating

NCT02104167
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ROIC interbody cage with VerteBRIDGE plating
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
21 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Laguna Hills, California • Munster, Indiana • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 25, 2026, 11:05 PM EDT
Terminated Not applicable Interventional Results available

An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc at Two Contiguous Levels in the Cervical Spine

NCT03062657
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
Interventions
PRESTIGE LP™ Cervical Disc
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
4
States / cities
Beverly Hills, California • Royal Oak, Michigan • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 25, 2026, 11:05 PM EDT
Recruiting Not applicable Interventional

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

NCT06485206
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
One level Mobi-C and one level fusion
Device
Lead sponsor
Highridge Medical
Industry
Eligibility
22 Years to 69 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Sacramento, California • Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Not listed Not applicable Interventional

Baxter: Actifuse SHAPE vs DBX in ACC

NCT02005081
View directory record Official record
Conditions
Cervical Spine Degenerative Disease Nos, Cervical Spondylosis With Myelopathy
Interventions
Actifuse SHAPE, Autograft with Demineralized Bone Matrix
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 8, 2013 · Synced Sep 25, 2026, 11:05 PM EDT
Not yet recruiting No phase listed Observational

Assessing Safety of Cervical Spine Fusion With NMP®

NCT07245940
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis Cervical
Interventions
Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Red Rock Regeneration Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Terminated No phase listed Observational

Interbody Systems: Post Market Clinical Follow-up Study

NCT04911257
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical or Lumbar Spinal fusion
Device
Lead sponsor
K2M, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Shreveport, Louisiana • Cleveland, Ohio • Oklahoma City, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional Results available

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

NCT00389597
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical Artificial Disc
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years to 69 Years
Enrollment
599 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
24
States / cities
Phoenix, Arizona • Escondido, California • Laguna Hills, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2017 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Phase 3 Interventional Results available

Performance of the Hedrocel(R) Cervical Fusion Device

NCT00758758
View directory record Official record
Conditions
Symptomatic Cervical Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 70 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
13
States / cities
Los Angeles, California • Clearwater, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 22, 2013 · Synced Sep 25, 2026, 11:05 PM EDT
Withdrawn Not applicable Interventional

Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion.

NCT03312192
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spine Degeneration
Interventions
Interbody Cage, Interbody Cage and Anterior Plating
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional

Hand Dexterity Training in Degenerative Cervical Myelopathy (DCM)

NCT06754072
View directory record Official record
Conditions
Degenerative Cervical Myelopathy
Interventions
Virtual Keyboard (VK) System
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 30, 2024 · Synced Sep 25, 2026, 11:05 PM EDT
Enrolling by invitation No phase listed Observational

Posterior Cervical Fixation Study

NCT04770571
View directory record Official record
Conditions
Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease, Cervical Fusion, Cervical Spine Disease, Cervical Myelopathy, Cervical Instabilities Spine, Thoracic Injury
Interventions
observational study
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Hyattsville, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)

NCT00942045
View directory record Official record
Conditions
Degenerative Disc Disease in Cervical Spine
Interventions
Biologic - Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
La Jolla, California • Redwood City, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional Results available

An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation

NCT00310440
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
P-15 Synthetic osteoconductive bone substitute, Autologous bone
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
10
States / cities
San Francisco, California • Thornton, Colorado • Sarasota, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 25, 2026, 11:05 PM EDT
Recruiting No phase listed Observational

MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine

NCT01788410
View directory record Official record
Conditions
Facet Joints; Degeneration, Neuropathy, Neuralgia
Interventions
Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical)
Procedure · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Sep 25, 2026, 11:05 PM EDT
Terminated Not applicable Interventional

Study of the Effect of Neck Treatment on Shoulder Impingement

NCT00764764
View directory record Official record
Conditions
Shoulder Impingement, Shoulder Pain, Rotator Cuff Tendinitis, Cervical Degenerative Joint Disease
Interventions
shoulder treatment, Shoulder AND cervical treatment
Procedure
Lead sponsor
CAMC Health System
Other
Eligibility
40 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 25, 2026, 11:05 PM EDT
Not yet recruiting Not applicable Interventional

Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease

NCT07721493
View directory record Official record
Conditions
Degenerative Disc Disease(DDD)
Interventions
Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion
Device · Procedure
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional

Early Postoperative Home Exercise Program After Cervical Spine Surgery

NCT02720172
View directory record Official record
Conditions
Spinal Fusion, Cervical Spine Degenerative Disease
Interventions
Early Home Exercise Program, Usual Care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 25, 2026, 11:05 PM EDT
Recruiting Not applicable Interventional

Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy

NCT06202443
View directory record Official record
Conditions
Cervical Spine Degeneration, ACDF Surgery
Interventions
Early PT, Delayed PT
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Honolulu, Hawaii • Nashville, Tennessee • Fort Sam Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 25, 2026, 11:05 PM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional Results available

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels

NCT00637156
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
Interventions
PRESTIGE LP device at two adjacent levels, Bi-level fusion with ATLANTIS Cervical Plate System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
397 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
29
States / cities
Huntsville, Alabama • Beverly Hills, California • Colton, California + 26 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 25, 2026, 11:05 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Salt Water Gargling on Swallowing Following ACDF

NCT06475365
View directory record Official record
Conditions
Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis, Cervical Myelopathy, Dysphagia
Interventions
Sodium chloride gargle
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 25, 2026, 11:05 PM EDT
Completed Not applicable Interventional

Comparison of Outcomes Between Early Physical Therapy Intervention and Usual Care Following Anterior Cervical Fusion Surgery

NCT01519115
View directory record Official record
Conditions
Cervical Spine Degenerative Disc Disease, Fusion of Spine, Cervical Region
Interventions
early physical therapy intervention, usual care
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
30 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2015 · Synced Sep 25, 2026, 11:05 PM EDT
Recruiting No phase listed Observational

Clinical Outcome Measure at Stryker Spine

NCT06226272
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Scoliosis
Interventions
Spinal Fusion, Spinal Deformities Correction
Device
Lead sponsor
VB Spine, LLC
Industry
Eligibility
18 Years and older
Enrollment
5,222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
7
States / cities
Jacksonville, Florida • Scarborough, Maine • Southfield, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 25, 2026, 11:05 PM EDT
Terminated No phase listed Observational

PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.

NCT05489822
View directory record Official record
Conditions
Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
Interventions
VERTICALE® Cervical System
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 11:05 PM EDT