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Showing 1–24 of 71 matching trials from the live ClinicalTrials.gov search.
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Not yet recruiting Not applicable Interventional

AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults

NCT07701668
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Social Isolation
Interventions
AI-based conversational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Not yet recruiting Phase 2 Interventional

BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases

NCT07550088
View directory record Official record
Conditions
Colorectal Cancer Metastatic
Interventions
Balstilimab (BAL), Botensilimab (BOT), agenT-797
Drug
Lead sponsor
Darren Sigal, MD
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial

NCT07107152
View directory record Official record
Conditions
Colorectal Cancer Control and Prevention
Interventions
single GPT generated message, AI Chatbot, Expert-Written Patient Materials
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 75 Years
Enrollment
915 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Completed No phase listed Observational

A Chatbot-Powered G8 Screening Intervention to Facilitate Referrals to a Comprehensive Geriatric Assessment Among Older Adults With Cancer

NCT05535140
View directory record Official record
Conditions
Geriatric Cancer Patients
Interventions
G8 Screening Tool
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Choices About Genetic Testing And Learning Your Risk With Smart Technology

NCT06184867
View directory record Official record
Conditions
Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Breast Cancer, Pancreas Cancer, Colorectal Cancer, Endometrial Cancer, Prostate Cancer
Interventions
Relational Agent (RA), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

AI-Based Personalized Health and Self-Care

NCT07168382
View directory record Official record
Conditions
Social Needs Status, Unmet Health-Related Social Needs and Access to Community Resources, Primary Health Care and Access to Primary Care, Technology Use to Support Caregivers, Caregiver Burden, Health Status, Child and Infant Care, Preventative Care Services
Interventions
DAPHNE Chatbot Intervention, Standard HRSN Screening and Referral (Usual Care)
Behavioral · Other
Lead sponsor
Emre Sezgin
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

NCT07445074
View directory record Official record
Conditions
Epilepsy, Seizure
Interventions
Medilepsy® Chatbot AI-Enhanced, Medilepsy® Chatbot Standard
Other
Lead sponsor
University of Central Florida
Other
Eligibility
14 Years to 24 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Terminated Not applicable Interventional

Digital Therapeutic vs Educational App for Depression Among Adolescents

NCT05486611
View directory record Official record
Conditions
Depression
Interventions
W-GenZD Mobile Application, Digital Education Application (W-EdZD)
Device
Lead sponsor
Woebot Health
Industry
Eligibility
13 Years to 17 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2022 · Synced Jul 22, 2026, 2:38 PM EDT
Not yet recruiting Not applicable Interventional

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

NCT07214831
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Large language model-based chatbot brief alcohol intervention session
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

Artificial Intelligence-Powered Support For Quality Of Life Improvement In Participants With Cancer

NCT07167056
View directory record Official record
Conditions
Cancer
Interventions
Standard of Care Psychotherapy, WYSA App
Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Leveraging Chatbot to Improve PrEP in the Southern United States

NCT05968755
View directory record Official record
Conditions
HIV Prevention, PrEP Awareness, PrEP Uptake
Interventions
A chatbot designed to promote PrEP awareness and uptake for Black MSM, General educational messages
Device · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Male only
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
4
States / cities
Miami, Florida • Pembroke Pines, Florida • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Results available

Evaluation of an Alternative Injection Paradigm for OnabotulinumtoxinA (BOTOX®) in the Treatment of Overactive Bladder in Patients With Urinary Incontinence

NCT03052764
View directory record Official record
Conditions
Urinary Bladder, Overactive, Urinary Incontinence
Interventions
onabotulinumtoxinA, Placebo (saline)
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
31
States / cities
Laguna Hills, California • Los Angeles, California • Orange, California + 27 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Chatbot to Maximize Hereditary Cancer Genetic Risk Assessment

NCT05562778
View directory record Official record
Conditions
Gynecologic Cancer, Hereditary Cancer Syndrome
Interventions
Chatbot
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
4
States / cities
Brooklyn, New York • New York, New York • Queens, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Phase 2 Interventional

A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer

NCT05630183
View directory record Official record
Conditions
Metastatic Pancreatic Ductal Adenocarcinoma
Interventions
Botensilimab, Gemcitabine, Nab-paclitaxel
Drug
Lead sponsor
Agenus Inc.
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
36
States / cities
Scottsdale, Arizona • Los Angeles, California • Newport Beach, California + 28 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

Technology Assisted Motivational Interviewing

NCT06713603
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
TAMI Coach
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Oral Cancer Awareness

NCT06682494
View directory record Official record
Conditions
Oral Cancer, Chatbot, Patient Education, Prevention, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oropharyngeal Cancers
Interventions
Traditional Education, AI-powered Chatbox
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

PASCAL Feasibility Study

NCT07301151
View directory record Official record
Conditions
Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
chatbot, no chatbot
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Potency and Precision Investigation

NCT06240091
View directory record Official record
Conditions
Depression, Anxiety
Interventions
DISC-MA
Device
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 75 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Project CARE: CAncer Risk Evaluation

NCT07130487
View directory record Official record
Conditions
Primary Care
Interventions
Relational Agent ( RA) Alex
Behavioral
Lead sponsor
Anita Y. Kinney, PhD, RN
Other
Eligibility
18 Years to 70 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

NCT07534254
View directory record Official record
Conditions
Overweight and/or Obesity
Interventions
AGILE Intervention, Chatbot
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

AMIE's Clinical Conversational Abilities in an Urgent Care Setting

NCT06911398
View directory record Official record
Conditions
Artificial Intelligence (AI), Clinical Reasoning
Interventions
Articulate Medical Intelligence Explorer (AMIE)
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Enrolling by invitation Not applicable Interventional

Social Media Intervention for Online Victimized Youth

NCT06835985
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
Chatbot Intervention, Brief Psychoeducation
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication

NCT06053515
View directory record Official record
Conditions
Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
Interventions
Rosie the Chatbot
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
14 Years to 99 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Step Away: Comparing a Chatbot-delivered Alcohol Intervention With a Smartphone App

NCT04447794
View directory record Official record
Conditions
Alcohol Consumption, Alcohol Use Disorder
Interventions
Step Away Chatbot, Step Away App
Behavioral
Lead sponsor
University of Alaska Anchorage
Other
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Jul 22, 2026, 2:38 PM EDT