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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Daily Headache Clear all
Completed Not applicable Interventional

Acupuncture for the Treatment of Chronic Daily Headaches

NCT00086021
View directory record Official record
Conditions
Headache Disorders
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
2
States / cities
Boston, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2007 · Synced Jul 21, 2026, 11:34 PM EDT
Terminated Phase 4 Interventional Results available

Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

NCT02090998
View directory record Official record
Conditions
Transformed Migraine, Chronic Daily Headache
Interventions
SPG Block with 5% Lidocaine gel, Amitriptyline
Procedure · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional

Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Patients With Migraine

NCT01828684
View directory record Official record
Conditions
Migraine Disorders, Photophobia
Interventions
Therapeutic Lens Coating, Sham Lens Coating
Other
Lead sponsor
Bradley Katz
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional

Nutrition for Chronic Daily Headache

NCT01157208
View directory record Official record
Conditions
Chronic Daily Headache
Interventions
Diet A, Diet B
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 21, 2026, 11:34 PM EDT
Completed No phase listed Observational Results available

Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?

NCT00880425
View directory record Official record
Conditions
Chronic Daily Headache
Interventions
Not listed
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Jul 21, 2026, 11:34 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia

NCT05536050
View directory record Official record
Conditions
Chronic Migraine, Fibromyalgia, New Daily Persistent Headache
Interventions
Migraine diary and Questionnaires
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children

NCT03447782
View directory record Official record
Conditions
New Daily Persistent Headache (NDPH)
Interventions
Naltrexone HCl (Bulk) Powder
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional Results available

Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache

NCT00963040
View directory record Official record
Conditions
Chronic Daily Headache
Interventions
Syntocinon, Sterile water
Drug
Lead sponsor
MedVadis Research Corporation
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Wellesley Hills, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Jul 21, 2026, 11:34 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics

NCT03231241
View directory record Official record
Conditions
Chronic Daily Headache, Chronic Migraine
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Jul 21, 2026, 11:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

New Daily Persistent Headache Biomarkers Study

NCT04260087
View directory record Official record
Conditions
New Daily Persistent Headache, New Daily Persistent Headache (NDPH)
Interventions
Not listed
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Phase 1 Interventional

Atkins Diet for Difficult-to-Control Headaches in Teenagers

NCT00181064
View directory record Official record
Conditions
Chronic Daily Headache
Interventions
Modified Atkins diet
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 19 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2009 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional

Intensive Meditation and Migraines: Effects on Health and Well Being

NCT00663585
View directory record Official record
Conditions
Chronic Daily Headache
Interventions
Vipassana Meditation
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2016 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Offset Analgesia as a Measure of Central Sensitization in Children

NCT03445403
View directory record Official record
Conditions
Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder, CRPS (Complex Regional Pain Syndromes)
Interventions
Offset analgesia
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jul 21, 2026, 11:34 PM EDT
Terminated Not applicable Interventional

Yoga Training for Returning Veterans With Headache

NCT01993069
View directory record Official record
Conditions
Post Traumatic Headache, Chronic Daily Headache
Interventions
Iyengar-based Yoga Training
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Phase 3 Interventional

Headstrong Intervention for Pediatric Headache

NCT00269581
View directory record Official record
Conditions
Chronic Headaches
Interventions
Educational CD-rom, Headstrong CD-rom
Other
Lead sponsor
Michael Rapoff, Ph.D.
Other
Eligibility
7 Years to 12 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Kansas City, Kansas • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 24, 2012 · Synced Jul 21, 2026, 11:34 PM EDT
Completed Not applicable Interventional Results available

Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents

NCT01118988
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS), Myofacial Pain, Chronic Daily Headaches, Migraine Headaches, Chronic Pain
Interventions
Mentorship
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 18 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jul 21, 2026, 11:34 PM EDT