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Showing 1–24 of 418 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Pain Management Clear all
Completed Not applicable Interventional Results available

Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain

NCT01263054
View directory record Official record
Conditions
Back Pain
Interventions
TransDiscal System, Medical Management
Device · Other
Lead sponsor
Halyard Health
Industry
Eligibility
21 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
9
States / cities
Washington D.C., District of Columbia • Orlando, Florida • Bloomington, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Jul 22, 2026, 9:36 AM EDT
Recruiting Not applicable Interventional

Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

NCT07149870
View directory record Official record
Conditions
Chronic Pain
Interventions
Pain Management Team + Whole Health Coach (PMT-WHC), Pain Management Team-Usual Care (PMT-UC)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
5
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Aurora, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

Piloting IVR (Interactive Voice Response) for Chronic Pain Treatment

NCT00651924
View directory record Official record
Conditions
Chronic Pain
Interventions
IVR-based Cognitive-behavior therapy
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Jul 22, 2026, 9:36 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Observational Study of Integrated Chronic Pain Management in a Community Health Center

NCT04490291
View directory record Official record
Conditions
Chronic Pain, Spine Disease
Interventions
chronic pain team, chiropractic team
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

Strategies to Assist With Management of Pain

NCT03115359
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Mindfulness Based Therapy, Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
770 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
Boston, Massachusetts • Hershey, Pennsylvania • Salt Lake City, Utah + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 22, 2026, 9:36 AM EDT
Recruiting Not applicable Interventional

PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial

NCT06427356
View directory record Official record
Conditions
Chronic Pain
Interventions
PREVAIL Interdisciplinary Team
Behavioral
Lead sponsor
Salem Veterans Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Phase 4 Interventional Results available

Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain

NCT02886286
View directory record Official record
Conditions
Pain, Intractable, Breakthrough Pain, Chronic Pain
Interventions
Bupivacaine, Opioid
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
31 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Jul 22, 2026, 9:36 AM EDT
Completed No phase listed Observational

Patient Controlled Analgesia Pharmacogenetic Study

NCT01731873
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 18 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional

Virtual Reality for Pain Management in Advanced Heart Failure

NCT04572425
View directory record Official record
Conditions
Heart Failure，Congestive, Acute Pain, Chronic Pain
Interventions
Guided imagery, Virtual reality
Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Jul 22, 2026, 9:36 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT05419297
View directory record Official record
Conditions
Back Pain Lower Back Chronic, Chronic Pain
Interventions
Buprenorphine Buccal Film [Belbuca], Urine Drug Screening, actigraph, PROMIS 29, sit to stand test, numerical rating scale pain score, patient global impression of function, PROMIS - sleep
Drug · Other · Device + 1 more
Lead sponsor
Carolinas Pain Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jul 22, 2026, 9:36 AM EDT
Active, not recruiting Not applicable Interventional

Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures

NCT06235996
View directory record Official record
Conditions
Chronic Pain
Interventions
Office-based procedure indicated for chronic pain with music, Office-based procedure indicated for chronic pain without music
Procedure
Lead sponsor
Lake Erie College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Wesley Chapel, Florida • Zephyrhills, Florida
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Phase 3 Interventional Results available

A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain

NCT01571362
View directory record Official record
Conditions
Chronic Pain, Low Back Pain, Analgesia
Interventions
ALO-02, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
52
States / cities
Mobile, Alabama • Goodyear, Arizona • Phoenix, Arizona + 38 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jul 22, 2026, 9:36 AM EDT
Active, not recruiting Not applicable Interventional

Non-pharmacological Treatment for Pain After Spine Surgery

NCT04770480
View directory record Official record
Conditions
Low Back Pain, Chronic Pain, Surgery, Back Pain, Low, Back Pain Lower Back Chronic
Interventions
Standard Care (SC), Enriched Pain Management Pathway (EPM)
Behavioral
Lead sponsor
Dan Rhon
Federal
Eligibility
18 Years to 75 Years
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Honolulu, Hawaii • San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Not listed No phase listed Observational

EHR Precision Drug Treatment in Neonates

NCT04850079
View directory record Official record
Conditions
Pain, Acute, Pain, Chronic
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
24 Weeks to 12 Months
Enrollment
200 participants
Timeline
2018 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump

NCT00884650
View directory record Official record
Conditions
Cerebral Palsy
Interventions
oral analgesic, intravenous analgesic per pump
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
3 Years to 17 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Jul 22, 2026, 9:36 AM EDT
Recruiting Not applicable Interventional

Weighted Blanket Use for Adults With Chronic Pain

NCT07498491
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Sleep Disturbance, Pain Disorders
Interventions
Weighted Blanket
Device
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Phase 2 Interventional Results available

Intravenous(IV) vs. Erector Spinae Plane Blocks in Cardiac Surgery

NCT04995497
View directory record Official record
Conditions
Erector Spinae Plane Block, Pain Control, Post-Operative Pain, Chronic
Interventions
Intravenous Administration of Lidocaine Post Cardiac Surgery, Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
Drug
Lead sponsor
Archit Sharma
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jul 22, 2026, 9:36 AM EDT
Terminated No phase listed Observational

Lexington Observational Study of Treatment With Compounded Pain Creams

NCT02195752
View directory record Official record
Conditions
Chronic Pain, Acute Pain
Interventions
Compounded Pain Cream
Other
Lead sponsor
Lexington Independent Studies, LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Laguna Hills, California • Gary, Indiana
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment, Pain, and Opioids

NCT05363176
View directory record Official record
Conditions
Chronic Pain
Interventions
Cognitive-Behavioral Therapy for Treatment Seeking, Pain treatment education
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Low-intensity Focused Ultrasound for Human Pain Management

NCT05145426
View directory record Official record
Conditions
Chronic Pain
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jul 22, 2026, 9:36 AM EDT
Terminated No phase listed Observational

Study to Evaluate Outcomes of Patients Receiving Treatment for Wound Care, Pain Management or Surface Skin Scar Therapy

NCT02445235
View directory record Official record
Conditions
Chronic Pain, Fungal Infection
Interventions
Patient Reported Outcome Survey Tool
Other
Lead sponsor
Bracane Company
Industry
Eligibility
18 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Lexington, Kentucky • Sevierville, Tennessee • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 19, 2016 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

Home-Based Exercise and Weight Control Program for Pain Control in Overweight Elderly With Osteoarthritis of the Knee

NCT00126737
View directory record Official record
Conditions
Chronic Diseases, Obesity, Osteoarthritis, Pain
Interventions
Weight Control Nutritional Program, Home-based exercise program
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Phase 2 Interventional Results available

Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis

NCT03098563
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Blinded study medication
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
45 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Jul 22, 2026, 9:36 AM EDT
Completed Early Phase 1 Interventional

Prevention of Post Mastectomy With Intraoperative Ketamine

NCT03090776
View directory record Official record
Conditions
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Interventions
Ketamine, Placebo saline
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 9:36 AM EDT